Berberine bisulfate

433.43

433.083130

211-196-4

69A4M9800W

150444

YELLOW CRYSTALS

127

3.18170

Off-white to yellow powder.

274-275 °C (decomp)

INSOL IN CHLOROFORM /TRIHYDRATE/

RED-YELLOW NEEDLES /TRIHYDRATE/|YELLOW NEEDLES /TRIHYDRATE/|SOLUBLE IN ABOUT 30 PARTS WATER, IN ALC /TRIHYDRATE/

III

6.1(b)

1544

3

20/21/22

36

DR9867000

Xn

P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, P501

H301

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

LD50 RATS ORAL MORE THAN 1 G/KG|LD50 RATS INTRAPERITONEAL 88.5 MG/KG|LD50 RATS INTRAMUSCULAR 14.5 MG/KG

SHOULD NOT BE HANDLED EXCESSIVELY, SINCE IT MAY BE ABSORBED THROUGH THE SKIN AND HAVE TOXIC EFFECT UPON THE BODY. /BERBERINE/

EXPTL USE (VET): ORALLY ADMIN BERBERINE SULFATE (350-700 MG/KG) WAS EFFECTIVE IN TREATING CANDIDA ALBICANS INFECTIONS OF THE INTESTINE IN MICE.|EXPTL USE: DILATION OF HUMAN EYE PUPILS, TOPICAL ANESTHESIA &/OR FLUORESCENT STAINING OF CORNEAL EPITHELIAL DEFECTS &/OR FLUORESCENCE IN APPLANATION TONOMETRY, IS ACCOMPLISHED BY TOPICAL APPLICATION OF OPHTHALMIC SOLN OF HYDRASTIS COMPD SUCH AS BERBERINE.|/PRC: FORMER USES/ BITTER STOMACHIC; ANTIBACTERIAL; ANTIMALARIAL; ANTIPYRETIC /BERBERINE/|MILD LOCAL ANESTHETIC ON MUCOUS MEMBRANE. /BERBERINE/

...MAY BE ABSORBED THROUGH THE SKIN... /BERBERINE/

TOXIC DOSES DEPRESS HEART (DIRECTLY & REFLEXLY THROUGH THE VAGUS), RELAX BLOOD VESSELS, DEPRESS RESPIRATIONS, & STIMULATE SMOOTH MUSCLE IN INTESTINES, BRONCHI, & POSSIBLY UTERUS. /BERBERINE/|AN ALKALOID POISON. IN TOXIC DOSES IT LOWERS TEMPERATURE, INCREASES PERISTALSIS, AND CAUSES DEATH BY CENTRAL PARALYSIS. /BERBERINE/|TOXIC BY INGESTION, INHALATION, AND SKIN ABSORPTION. /BERBERINE/

/BERBERINE IS/ ALKALOID, USUALLY AS SULFATE; OBTAINED FROM RHIZOMES AND ROOTS OF HYDRASTIS CANADENSIS.|/BERBERINE/...BEHAVES AS A QUATERNARY BASE, FORMING SALTS BY REPLACEMENT OF THE OH GROUP: PERKIN, JR, J CHEM SOC 113, 503 (1918). /BERBERINE/

MICROCHEMICAL TESTS FOR ALKALOIDS AND RELATED AMINES...REAGENT: HYDROCHLORIC ACID. /BERBERINE/|BERBERINE SULFATE IN 95% ETHANOL WAS SUBJECTED TO THIN LAYER CHROMATOGRAPHY.