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Glutamic acid

Glutamic acid structure

CAS No:
617-65-2
Formula:
C5H9NO4
Chemical Name:
Glutamic acid
Synonyms:
Glutamic acid;Glutamic acid,DL-;DL-Glutamic acid;(±)-Glutamic acid;DL-Glu;Glutaminic acid;NSC 206301;NSC 9967;4-Amino-1,5-pentanedioic acid;2-Aminopentanedioic acid
Categories:
Pharmaceutical Intermediates > Antineoplastics

Description

White solid

Glutamic acid is an alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a 2-carboxyethyl group. It is a conjugate acid of a glutamate(1-).|A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.

Glutamic acid Basic Attributes

Molecular Weight：

147.12900

Exact Mass：

147.13

EC Number：

200-293-7

NSC Number：

206301|620337|143503|77686|9967

DSSTox ID：

DTXSID0046987

HScode：

29224210

Characteristics

PSA：

100.62000

XLogP3：

-3.7

Appearance：

White crystals or crystalline powder

Density：

1.409 g/cm3

Melting Point：

199 °C (decomp)

Boiling Point：

94-97 °C @ Press: 3 Torr

Flash Point：

155.7ºC

Refractive Index：

1.522

Water Solubility：

Insoluble in methanol, ethanol, ether, acetone, cols glacial acetic acid and common neutral solvents.

Storage Conditions：

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Vapor Pressure：

<1.10X10-5 mm Hg at 20 deg C (OECD Guideline 104 (Vapor Pressure Curve))

Specific rotation：

[α]D/20 between + 31,5° and + 32,2°; (10 % solution (anhydrous basis) in 2N HCl, 200 mm tube)

Odor：

Odorless

Taste：

Umami sour taste

PH：

Between 3,0 and 3,5 (saturated solution)

Safety Information

safety instructions：

24/25

RTECS Number：

LZ9648000

Stability/Shelf Life：

Stable under recommended storage conditions. /L-Glutamic acid hydrochloride/

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

Drug Information

MeSH Entry Terms：

Aluminum L Glutamate

Glutamic acid Use and Manufacturing

Uses

Glutamic Acid is non-essential amino acid. Its salt form (glutamate) is an important neurotransmitter that plays a key role in long-term potentiation and is important for learning and memory. Glutamic Acid is also a key molecule in cellular metabolism.

Manufacturing Info：

Glutamic acid: ACTIVE

Computed Properties

Molecular Weight:147.13
XLogP3:-3.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:147.05315777
Monoisotopic Mass:147.05315777
Topological Polar Surface Area:101
Heavy Atom Count:10
Complexity:145
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Acrylonitrile

Ethanol

Formic acid

Acetic acid

Methanol

Benzene

Hydrochloric acid

Ammonia

Sulfuric acid

Downstream Products

Glycine

Acetic acid

Drug Function and Efficacy

Amino acid involved in skin barrier function and natural moisturizing factor (NMF)

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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