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Distamycin A

Distamycin A structure

CAS No:
636-47-5
Formula:
C22H27N9O4
Chemical Name:
Distamycin A
Synonyms:
1H-Pyrrole-2-carboxamide,N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-;N,4′:N′,4′′-Ter[pyrrole-2-carboxamide],N′′-(2-amidinoethyl)-4-formamido-1,1′,1′′-trimethyl-;N-[5-[[(3-Amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-1H-pyrrole-2-carboxamide;Distamycin A;Stallimycin;Distamycin 3;NSC 82150

Description

Stallimycin is an oligopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces distallicus. Distamycin preferentially binds to adenine-thymine (A-T) rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and RNA transcription. In addition to antitumor effects, distamycin also possesses antiviral and antiprotozoal activities and is used as a chromosome dye. (NCI04)

Distamycin A Basic Attributes

Molecular Weight：

481.517

Exact Mass：

481.51

UNII：

80O63P88IS

NSC Number：

82150

DSSTox ID：

DTXSID9045637

NCI Thesaurus Code：

C1517

Characteristics

PSA：

181

XLogP3：

2.87670

Density：

1.45g/cm3

Melting Point：

154-156 °C

Refractive Index：

1.69

Drug Information

MeSH：

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

MeSH Entry Terms：

distamycin

Computed Properties

Molecular Weight:481.5
XLogP3:-1.8
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:481.21860038
Monoisotopic Mass:481.21860038
Topological Polar Surface Area:181
Heavy Atom Count:35
Complexity:825
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Distamycin A

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Learn More Other Chemicals

Distamycin A

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