 Home > Encyclopedia > Clotiapine

Clotiapine

Clotiapine structure

CAS No:
2058-52-8
Formula:
C18H18ClN3S
Chemical Name:
Clotiapine
Synonyms:
Dibenzo[b,f][1,4]thiazepine,2-chloro-11-(4-methyl-1-piperazinyl)-;2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo[b,f][1,4]thiazepine;LW 2159;2-Chloro-11-(4-methylpiperazino)dibenzo[b,f][1,4]thiazepine;Clothiapine;Clotiapine;HF 2159;Etumine;Clothiapin;Entumine;Deliton;Etomine
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Clotiapine is a dibenzothiazepine.|Clothiapine has been approved in European countries and is an atypical antipsychotic, shown to be useful in some treatment-resistant patients.

Clotiapine Basic Attributes

Molecular Weight：

343.87

Exact Mass：

343.87

EC Number：

218-162-8

UNII：

Z05HCY0X1T

DSSTox ID：

DTXSID5022851

ATC Code：

N - Nervous system

HScode：

2934999090

Characteristics

PSA：

44.14000

XLogP3：

3.13

Density：

1.3±0.1 g/cm3

Melting Point：

119 °C

Boiling Point：

483.8±55.0 °C at 760 mmHg

Flash Point：

246.4±31.5 °C

Refractive Index：

1.691

Toxicity：

Oral-Rat LD50: 280 mg/kg; Oral-Mouse LD50: 270 mg/kg

Flammability characteristics：

Combustible, it decomposes toxic chloride, sulfur oxide and nitrogen oxide gas when burning

Safety Information

Storage features：

Treasury is low temperature, ventilated, dry; stored separately from food raw materials

GHS Classification：

|Danger|H301 (75%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P273, P301+P310, P301+P312, P304+P312, P304+P340, P312, P321, P330, P391, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

MeSH Entry Terms：

clothiapine

Clotiapine Use and Manufacturing

Uses

Antipsychotic.

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:343.9
XLogP3:3.6
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:343.0909965
Monoisotopic Mass:343.0909965
Topological Polar Surface Area:44.1
Heavy Atom Count:23
Complexity:450
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes