Product
Supplier
Encyclopedia
Inquiry
Home > Encyclopedia > 1-Decanol

1-Decanol

pharmaceutical raw materials
1-Decanol structure

1-Decanol 

structure
  • CAS No:

    112-30-1

  • Formula:

    C10H22O

  • Chemical Name:

    1-Decanol

  • Synonyms:

    1-Decanol;Decyl alcohol;Capric alcohol;Caprinic alcohol;n-Decyl alcohol;Nonylcarbinol;Sipol L 10;Alfol 10;T 148;n-Decanol;Decanol;Antak;Epal 10;1-Hydroxydecane;Royaltac;Kalcohl 10H;Conol 10N;Nacol 10-99;Kalcohl 1098;Nacol 10;Nafol 10;NSC 406313;Kalcol 1098;Nafol 10D;Kalcohl 10;Conol 1098;Lorol C 10-98;Capryl alcohol;Lorol C 10

  • Categories:

    Cosmetic Ingredient  >  Foam Boosting

Description

COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.


Decyl alcohol appears as a clear colorless liquid with a sweet fat-like odor. Flash point 180°F. Less dense than water and insoluble in water. Vapors are heavier than air.|Liquid|COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.|colourless liquid/floral, waxy, fruity odour


Decyl alcohol appears as a clear colorless liquid with a sweet fat-like odor. Flash point 180°F. Less dense than water and insoluble in water. Vapors are heavier than air.|Decan-1-ol is a fatty alcohol consisting of a hydroxy function at C-1 of an unbranched saturated chain of ten carbon atoms. It has a role as a metabolite and a protic solvent. It is a primary alcohol and a fatty alcohol.

1-Decanol Basic Attributes

158.28

158.28

1735221

203-956-9

89V4LX791F

1490

406313

1987|3082

DTXSID7021946|DTXSID3034589|DTXSID2028301

Colorless to water-white liquid|Colorless, viscous, refractive liquid|Moderately viscous, strongly refractive liquid

29051900

Characteristics

20.2

4.6

Clear colorless to slightly yellow Liquid

0.8297 g/cm3 @ Temp: 20 °C

6.4 °C

232.9 °C @ Press: 760 Torr

180 °F

1.436-1.438

H2O: insoluble ;ethanol: soluble 60%, clear, colorless (1mL/3mL)

room temp

1 mm Hg ( 70 °C)

4.5 (vs air)

Oral-Rat LD50: 4720 mg/kg; Oral-Mouse LD50: 6500 mg/kg

Flammable; burning produces irritating fumes

0.9-5.7%(V)

Sweet odor

SLIGHT, CHARACTERISTIC FATTY TASTE

3.20e-05 atm-m3/mole|Henry's Law constant = 4.7831X10-5 atm-cu m/mol at 25 °C

Solidifies /at 6.4 °C/, forming rectangular plates or leaflets|Conversion factors: 1 mg/L= 154.5 ppm; 1 ppm= 6.47 mg/cu m at 25 °C, 760 mm Hg|Liquid molar volume = 0.191772 cu m/kmol|Heat of formation = -4.0166X10+8 J/kmol|For more Other Experimental Properties (Complete) data for 1-DECANOL (7 total), please visit the HSDB record page.

Insoluble in water.

Alcohols and Polyols

DECYL ALCOHOL attacks plastics. REF [Handling Chemicals Safely, 1980. p. 236]. Acetyl bromide reacts violently with alcohols or water, [Merck 11th ed., 1989]. Mixtures of alcohols with concentrated sulfuric acid and strong hydrogen peroxide can cause explosions. Example: An explosion will occur if dimethylbenzylcarbinol is added to 90% hydrogen peroxide then acidified with concentrated sulfuric acid. Mixtures of ethyl alcohol with concentrated hydrogen peroxide form powerful explosives. Mixtures of hydrogen peroxide and 1-phenyl-2-methyl propyl alcohol tend to explode if acidified with 70% sulfuric acid, [Chem. Eng. News 45(43):73(1967); J, Org. Chem. 28:1893(1963)]. Alkyl hypochlorites are violently explosive. They are readily obtained by reacting hypochlorous acid and alcohols either in aqueous solution or mixed aqueous-carbon tetrachloride solutions. Chlorine plus alcohols would similarly yield alkyl hypochlorites. They decompose in the cold and explode on exposure to sunlight or heat. Tertiary hypochlorites are less unstable than secondary or primary hypochlorites, [NFPA 491 M, 1991]. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

550 °F (USCG, 1999)|550 °F (288 °C)|255 °C

-9980 cal/g

Flammability limits = 0.7 to 5.5 vol%

NON-CORROSIVE

81.50 kJ/mol at 225 °C

Critical temperature: 690 K; critical pressure: 2.3 MPa|Critical temp = 690.00 deg K; Critical pressure = 2.3700X10+6 Pa

Safety Information

III

9

UN 3082 9/PG 3

1

20-36/37/38-51/53-36/38-52/53-36

26-60-61-37/39-29-36

HE4375000

Xn,N,Xi

Warehouse ventilated, low temperature and dry

Stable in mildly acidic & alkaline solutions

P201, P202, P261, P264, P271, P273, P280, P281, P301+P310, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P331, P337+P313, P391, P403+P233, P405, P501

H304

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Reacts violently with acid anhydrides, acid chlorides and strong oxidants.

1-Decanol is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and b) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.

USEPA/Office of Prevention, Pesticides and Toxic Substances; Reregistration Eligibility Decision Document - Aliphatic Alcohols, EPA 738-R-07-004 (March 2007). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of June 2, 2015: http://www.epa.gov/pesticides/reregistration/status.htm]

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)|Combustible.

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 24 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315 (52.91%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P273, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362, P391, and P501|Aggregated GHS information provided by 3520 companies from 25 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Not Classified|H227: Combustible liquid [Warning Flammable liquids]|P210, P264, P273, P280, P305+P351+P338, P337+P313, P370+P378, P403+P235, and P501|Danger|H304: May be fatal if swallowed and enters airways [Danger Aspiration hazard]|P201, P202, P261, P264, P271, P280, P281, P301+P310, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P331, P337+P313, P403+P233, P405, and P501

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 127 [Flammable Liquids (Water-Miscible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Goggles or face shield. (USCG, 1999)|Chemical-resistant apron when cleaning equipment, mixing or loading. Chemical-resistant footwear plus socks. Chemical-resistant headgear for over head exposure. Coveralls over short-sleeved shirt and short pants. Protective eye wear. Waterproof gloves.|Goggles or face shield.

Combustible when exposed to heat or flame...

Lower, 0.9%; Upper, 5.7% by volume in air.|Explosive limits , vol% in air: 0.7-5.5

Wear self-contained breathing appartus for firefighting if necessary. Use water spray to cool unopened containers. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist, or gas. Ensure adequate ventilation. Remove all sources of ignition. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.|Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up: contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulation... Keep in suitable closed containers for disposal.|Do NOT let this chemical enter the environment. Cover the spilled material with absorbent. Collect leaking liquid in sealable containers.|AEROBIC: A 5-day theoretical BOD of 36.3% was observed for 1-decanol in a standard BOD dilution test using a mixed microbial inoculum(1-2). Using a Warburg respirometer technique and various activated sludge inoculum, respective 6-hr, 12-hr and 24-hr theoretical BODs of 0.9, 9.2 and 29.3% were observed(3). In an aerobic screening test using a sewage inoculum, a first-order biodegradation rate of 7.1X10-3/hr was observed(4) which corresponds to a half-life of about 4 days(SRC).|ANAEROBIC: 1-Decanol showed 73% theoretical methane production after 274 days incubation in the dark at 37 °C using a sewage inoculum obtained from a Swedish pilot plant biogas reactor treating municipal solid waste(1).

SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

The substance is irritating to the eyes and skin.|May cause irritation of nose, throat and skin.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Cover the spilled material with inert absorbent. Collect leaking and spilled liquid in sealable containers as far as possible.

Separated from strong oxidants, acid anhydrides and acid chlorides. Store in an area without drain or sewer access.

A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C.

The substance is irritating to the eyes and skin. The substance may cause effects on the central nervous system at high levels.

The substance defats the skin, which may cause dryness or cracking.

NO open flames.

Use ventilation.

Protective gloves.

Wear safety goggles.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Decanol is produced, as an intermediate or a final product, by process units covered under this subpart.

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

1-Decanol has been identified in aqueous effluents from chemical plants and oil processing facilities(1). Emissions of 1-decanol, in percent of total carbon emission, were identified in roadway emissions (0.01), bus parking garage, hot soak (0.58), bus parking garage, cold start (0.23), petroleum refinery emissions (0.01), lead smelter (0.11), and cast iron factory emissions (0.18) in Cairo, Egypt(2). 1-Decanol emission rate from paved road dust from Pasadena, CA, residential streets in 1988 was 10 ug/g(3). 1-Decanol was qualitatively detected in a sample collected from a sedimentation tank in a water treatment facility in Zurich, Switzerland(4).

URBAN/SUBURBAN: 1-Decanol was found in California at atmospheric concentrations of not detected and 0.1 ng/cu m in Bakersfield and Fresno, respectively(1). 1-Decanol was not detected in 4 outdoor samples; sample dates and concentrations were not reported(2).|INDOOR: 1-Decanol was detected in indoor air samples from 1 of 5 and 0 of 2 samples taken in a home for the elderly non-smoking and smoking residence, respectively(1). 1-Decanol was not detected in 2 schools; sample dates and concentrations were not reported(1).|RURAL/REMOTE: 1-Decanol was not detected in air samples from the Kern Wildlife Refuge, California(1).

1-Decanol is an ingredient in some household cleaning products(1).

Toxicity

moderately toxic

IDENTIFICATION AND USE: 1-Decanol is a colorless to water-white liquid with a sweet floral or fruity odor. It is used as a chemical intermediate in the production of esters and fragrances and as an artificial flavor in foods. It also finds use in synthetic detergents, lube additives, pharmaceuticals, cosmetics, rubber, and textiles. It is registered for pesticide use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. HUMAN EXPOSURE AND TOXICITY: A maximization test was carried out on 25 volunteers using a 3% concentration in petrolatum. No subject became sensitized. ANIMAL STUDIES: There was little evidence of developmental toxicity when 1-decanol was administered, by inhalation, for 7 hours per day (6 hours/day for 1-decanol) on gestation days 1-19 to approximately 15 pregnant rats. 1-Dodecanol was not mutagenic in the Ames test with or without metabolic activation. However, it was rather cytotoxic, and the maximum concentration that could be tested was 50 ug/plate. In another study it was reported to diminish cell mitotic activity and cause structural changes to chromosomes and the mitotic apparatus in Vicia faba after 14 hours exposure. Mice receiving i.p. injections of 1-dodecanol for eight weeks at total doses of up to 12.0 gm/kg showed no statistically significant increase in lung tumor rate relative to controls. ECOTOXICITY STUDIES: The hatching of mosquito eggs was inhibited at a dosage of 5 to 7 liters/hectare by 1-decanol. First, third and fourth instar larvae were killed at a dosage of 3 to 7 liters/hectare. First instar larvae were more sensitive to the alcohols than the older larvae.

... The uptake of cholic acid was unaffected by abdominal irradiation, but for glucose, galactose, and four fatty acids the direction and magnitude of the changes in uptake were influenced by the dose of irradiation and by the interval following exposure. The greater uptake of decanol at 6 weeks but lower uptake of decanol at 33 weeks reflected changes in the resistance of the intestinal unstirred water layer.|N-decyl alc induced nutritional encephalomalacia in 1-day-old chicks could be completely prevented by dietary supplementation of dl-alpha-tocopheryl acetate.

LD50 Rat oral 4,720 mg/kg|LD50 Rabbit skin 3,560 mg/kg

1-Decanol has been reported in essential oils of ambrette seeds and almond flowers; in citrus oils, bilberry, American cranberry, papaya, raspberry, coriander seeds and cardamom(1).|1-Decanol was qualitatively detected as a volatile flavor component in the juice of Kogyoku apples(1). It has also been detected in the essential oil of oranges(2). 1-Decanol emission rates from green leaf composite samples and dead leaves were 11 ug/g and 7 ug/g, respectively(3).

1-Decanol's production and use in the perfume industry, as a raw material for detergents, in synthetic lubricants and plasticizers, and as an anti-foam agent(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), a reported log Koc value of 2.59(2), indicates that 1-decanol is expected to have moderate mobility in soil(SRC). Volatilization of 1-decanol from moist soil surfaces is expected(SRC) given a Henry's Law constant of 4.78X10-5 atm-cu m/mole(3). 1-Decanol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.51X10-3 mm Hg at 25 °C(4). Various biological screening studies have demonstrated that 1-decanol biodegrades readily(5-7); therefore, biodegradation is expected to be an important process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), a reported log Koc value of 2.59(2), indicates that 1-decanol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 4.78X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 27 hours and 12 days, respectively(SRC). 1-Decanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(5), an estimated BCF of 20(SRC), from its log Kow of 4.57(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Various biological screening studies have demonstrated that 1-decanol biodegrades readily(8-10); therefore, biodegradation is expected to be an important process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-decanol, which has a vapor pressure of 8.51X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-decanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 25 hours(SRC), calculated from its rate constant of 1.5X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 1-Decanol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 1-decanol with photochemically-produced hydroxyl radicals has been estimated as 1.5X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 25 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1-Decanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 1-Decanol does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 20 was calculated in fish for 1-decanol(SRC), using a log Kow of 4.57(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

389.05 L/kg|The log Koc of 1-decanol has been reported as 2.59(1). According to a classification scheme(2), this log Koc value suggests that 1-decanol is expected to have moderate mobility in soil.

The Henry's Law constant for 1-decanol is reported as 4.78X10-5 atm-cu m/mole(1). This Henry's Law constant indicates that 1-decanol is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 27 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 12 days(SRC). 1-Decanol's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 1-Decanol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.51X10-3 mm Hg(3).

GROUND WATER: 1-Decanol was qualitatively detected in well waters collected from wells in the vicinity of an industrial waste dump located along the Llobregat River in Spain(1); it was thought that its presence in the well water was a result of leaching from the waste dump(1).|DRINKING WATER: 1-Decanol was qualitatively detected in drinking water samples collected from Ottumwa, IA (Sep 1976), Philadelphia, PA (Feb 1976), and Seattle, WA (Nov 1976)(1).|SURFACE WATER: 1-Decanol was qualitatively detected in water samples taken from Lake St. Clair in the Great Lakes ecosystem(1).|RAIN/SNOW/FOG: 1-Decanol was not detected in snow surface samples from three different sampling events from 1985-1991 in the Antarctic at Mt. Crummer, Campbell Glacier, Vegetation Island, Mt. Melbourne, Carezza Lake, but was detected at Tourmaline Plateau at 12 ng/L(1). Two sites were analyzed at different snow depths; Styx Glacier (surface 232 ng/L, 1 meter deep 2350 ng/L, 2 meters deep 650 ng/L) and McCarthy Ridge (surface 511 ng/L, 1 meter deep 107 ng/L, 2 meters deep 134 ng/L)(1). Snow surface analysis were done for 1-decanol on seven sites in the Antarctic in 1993/1994 season; Wood Bay at sea level (5 ng/L), Mt Melbourne at 200 meters above sea level (below detection limit), Vegetation Island at 220 meters above sea level (10 ng/L), Mt Melbourne at 600 meters above sea level (below detection limit), McCarthy Ridge at 790 meters above sea level (below detection limit), Mt Melbourne at 1130 meters above sea level (4 ng/L) and Hercules Neve at 2960 meters above sea level (7 ng/L)(2). 1-Decanol was detected at 11, 10 and 2 ng/L at respective depths of 1, 2 and 3 meters, in subsurface snow samples from McCarthy Ridge(2). 1-Decanol was detected at 2, <2 and 9 ng/L at respective depths of 1, 2 and 3 meters in subsurface snow samples taken from Hercules Neve(2).

1-Decanol was qualitatively detected as a volatile flavor component in the juice of Kogyoku apples(1). 1-Decanol was identified as a volatile component of heated peanut oil(2). 1-Decanol has been reported in fermented beverages, apple juice, milk, butter, beef, pork, beer, cognac, whiskey, red, white and sparkling wines(3). 1-Decanol has been detected in beer, wine and spirits(4).

ENVIRONMENTAL: 1-Decanol has been reported in milk(1).

According to the 2012 TSCA Inventory Update Reporting data, 6 reporting facilities estimate the number of persons reasonably likely to be exposed in the manufacturing, processing, or use of 1-decanol in the United States may be as low as <10 workers up to the range of 500-999 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 241,397 workers (62,584 of these are female) were potentially exposed to 1-decanol in the US(1). Occupational exposure to 1-decanol may occur through inhalation and dermal contact with this compound at workplaces where 1-decanol is produced or used(SRC). 1-Decanol was detected in air samples from 1 of 3 offices; sample dates and concentrations were not reported(2). Monitoring data indicate that the general population may be exposed to 1-decanol via inhalation of ambient air, ingestion of food and drinking water, and dermal contact with consumer products containing 1-decanol(SRC).

1-Decanol was qualitatively detected in expired air of humans having diabetic conditions(1); it was not detected (detection limit not reported) in expired air of non-diabetic humans(1).

Drug Information

Direct contact can produce eye irritation; low general toxicity. (USCG, 1999)

CONTACT WITH EYES: flush with water for 15 min. (USCG, 1999)


Fresh air, rest.


Remove contaminated clothes. Rinse and then wash skin with water and soap.


First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Higher alcohols (>3 carbons) and related compounds/|Basic Treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Higher alcohols (>3 carbons) and related compounds/|Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques, with a bag-valve-mask device, may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose strip or glucometer readings below 50 mg) and administer 50% dextrose if necessary ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Higher alcohols (>3 carbons) and related compounds/

/HUMAN EXPOSURE STUDIES/ A maximization test was carried out on 25 volunteers using a 3% concentration in petrolatum. No subject became sensitized ... .|/SIGNS AND SYMPTOMS/ The substance is irritating to the eyes and the skin. The substance may cause effects on the central nervous system at high levels.

1-decanol

The substance can be absorbed into the body by inhalation of its aerosol.

Cough. Sore throat.


Dry skin. Redness.


Redness.

1-Decanol Use and Manufacturing

Methods of Manufacturing

Natural products are made from coconut oil, catalyzed by mixed oxides, hydrogenated at high temperature and pressure, and then decomposed under reduced pressure.

Uses

In the manufacture of plasticizers, synthetic lubricants, petroleum additives, herbicides, surface active agents, solvents.Has moderate antifoaming capacity.


Fuels and fuel additives|Functional fluids (closed systems)


Building/construction materials - wood and engineered wood products|Fuels and related products

Production

50,000,000 - 100,000,000 lb|1,000,000 - 10,000,000 lb|(1972) Greater than 9.1X10+6 grams|(1975) Greater than 4.54X10+5 grams|(1984) 1.28X10+10 g /Alcohols C11 or lower/|(1986) >10 million-50 million pounds|For more U.S. Production (Complete) data for 1-DECANOL (11 total), please visit the HSDB record page.

Emulsifiable concentrate.|Grades: Techical, high purity.|Royaltac (Macdermid Agricultural Solutions, Inc.): Active ingredient: 1-decanol 78.4%.|Royaltac-M (Macdermid Agricultural Solutions, Inc.): Active ingredient: lauryl alcohol 0.3%; 1-octanol 36.2%; 1-decanol 48.2%.|For more Formulations/Preparations (Complete) data for 1-DECANOL (23 total), please visit the HSDB record page.

All other basic organic chemical manufacturing|1-Decanol: ACTIVE|Oil and gas drilling, extraction, and support activities|Alcohols, C9-11: ACTIVE|Alcohols, C10-terpenoidal: ACTIVE|Found in sweet orange and a few other essential oils

Gas-liquid chromatography.

EPA Safer Chemical Functional Use Classes -> Fragrances|Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern|EPA Safer Chemical Functional Use Classes -> Solvents|Food additives -> Flavoring Agents|Agrochemicals -> Plant Growth Regulators|Flavoring Agents -> JECFA Flavorings Index|Fatty Acyls [FA] -> Fatty alcohols [FA05]|Cosmetics -> Emollient; Emulsion stabilizing; Viscosity controlling|Environmental transformation -> Pesticide transformation products (metabolite, successor)

Decanol is a known environmental transformation product of Dodine.

Flavoring Agents

Computed Properties

Molecular Weight:158.28
XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:8
Exact Mass:158.167065321
Monoisotopic Mass:158.167065321
Topological Polar Surface Area:20.2
Heavy Atom Count:11
Complexity:61.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Related Drugs

Recommended Suppliers of 1-Decanol

Scan the QR Code to Share

Feedback & Suggestions
Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.