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Home > Encyclopedia > 1-Tetradecanol

1-Tetradecanol

pharmaceutical raw materials
1-Tetradecanol structure

1-Tetradecanol 

structure
  • CAS No:

    112-72-1

  • Formula:

    C14H30O

  • Chemical Name:

    1-Tetradecanol

  • Synonyms:

    1-Tetradecanol;Tetradecanol;Lanette Wax KS;Loxanol V;Myristic alcohol;Myristyl alcohol;Tetradecyl alcohol;n-Tetradecyl alcohol;n-Tetradecanol;n-Tetradecan-1-ol;Lanette K;Alfol 14;1-Hydroxytetradecane;Kalcohl 40;1-Tetradecyl alcohol;Conol 1495;Adol 18;Kalcohl 4098;Nacol 14-95;Lanette 14;NSC 8549;Lorol C 14;Kalcol 4098;Hinol 14SS;Nacol 14-98;Speziol C 14 Pharma;Kolliwax MA;Hainol 14SS;Nafol 14;8032-14-2;150138-88-8

  • Categories:

    Cosmetic Ingredient  >  Emulsion Stabilising

Description

Myristyl alcohol occurs as a white crystalline solid with a waxy odor. Also reported as opaque leaflets or crystals from ethanol. white low melting solid or flakesChEBI: A long-chain fatty alcohol that is tetradecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group1-Tetradecanol is a kind of straight-chain saturated fatty alcohol. It is often used as an ingredient in cosmetics such as cold creams because of its emollient properties. It can also be used as the interm


Tetradecanol is a colorless thick liquid (heated) with a faint alcohol odor. Solidifies and floats on water. (USCG, 1999)|Liquid; OtherSolid; OtherSolid, Liquid; PelletsLargeCrystals; WetSolid|Liquid|DryPowder; Liquid; WetSolid; WetSolid, Liquid|OtherSolid|Solid


Tetradecanol is a colorless thick liquid (heated) with a faint alcohol odor. Solidifies and floats on water. (USCG, 1999)|Tetradecan-1-ol is a long-chain fatty alcohol that is tetradecane in which one of the terminal methyl hydrogens is replaced by a hydroxy group It is a long-chain primary fatty alcohol, a fatty alcohol 14:0 and a primary alcohol.

1-Tetradecanol Basic Attributes

214.39

214.39

1742652

204-000-3

V42034O9PU

8549

DTXSID9026926|DTXSID4028331|DTXSID0028117|DTXSID1029047|DTXSID4029802

White solid|White crystals|Leaflets

2905 19 00

Characteristics

20.2

6.03

White Low Melting Solid, Crystalline Powder, Crystals, Flakes, Pellets and/or Chunks

0.8165 g/cm3 @ Temp: 20 °C

39.5 °C

289 °C

>230 °F

1.4454

H2O: insoluble

−20°C

<1 hPa (20 °C)

7.4 (vs air)

LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

Henry's Law constant = 1.0399X10-4 atm-cu m/mol at 25 °C

Hydroxyl radical reaction rate constant = 2.1X10-11 cu cm/molec-sec at 25 °C (est)

Insoluble in water.

Alcohols and Polyols

TETRADECANOL is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

98.9 kJ/mol at 25 °C

Critical temperature: 743 K: critical pressure: 1.70 MPa

Safety Information

III

9

UN 3077 9 / PGIII

-

38-36

24/25-26

XB8655000

Xi

The bulk material should be stored in a well-closed container in a cool, dry place.

P273-P305 + P351 + P338-P501

H319-H410

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

...Can react with oxidizing materials.

Myristyl alcohol is an indirect food additive for use only as a component of adhesives.

|Warning|H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]|P273, P391, and P501|Aggregated GHS information provided by 470 companies from 2 notifications to the ECHA C&L Inventory.|H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]|Aggregated GHS information provided by 882 companies from 8 notifications to the ECHA C&L Inventory.|H315 (15.09%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P273, P280, P302+P352, P321, P332+P313, P362, P391, and P501|Aggregated GHS information provided by 859 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H319 (62.33%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P273, P280, P305+P351+P338, P337+P313, P391, and P501|Aggregated GHS information provided by 323 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315 (37.56%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P273, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362, P391, and P501|Aggregated GHS information provided by 2131 companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]|H315: Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362

Goggles or face shield. (USCG, 1999)|Safety glasses with side-shields conforming to EN 166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166 (EU).|Body Protection: Impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Respiratory protection: For nuisance exposures use type P95 (US) or type OP1 (EU EN 143) particle respirator. For higher level protection use type OV/AG/99 (US) or type ABEK-P2 (EU EN 143) respirator cartriges. Use respirator and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).|Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Combustible when exposed to heat or flame...

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.|Wear self contained breathing apparatus for fire fighting if necessary.|To fight fire use carbon dioxide, dry chemical.

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.|Prevent futher leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.|Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist, or gas. Ensure adequate ventilation. Avoid breathing dust.

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.

| 0 - Materials that, under emergency conditions, would offer no hazard beyond that of ordinary combustible materials.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

1-Tetradecanol was detected in an advanced waste treatment concentrate from a plant in Dallas, TX, in 1974(1). 1-Tetradecanol was detected in wastewater effluent at unreported concentrations from printing and publishing industries, textile mills, and publically-owned treatment works(one occurrence reported for each industry type)(2). 1-Tetradecanol emission from road dust samples was 3.6 ug/g(3). 1-Tetradecanol was emitted to the air at a rate of 6 ug/sq m hour from one of 10 cushion poly vinyl floorings installed for 3 days, the emission rate increased to 7 ug/sq m hour 28 days after installation(3).

URBAN/SUBURBAN: 1-Tetradecanol was detected, not quantified, in air samples collected along the Niagara River from Buffalo, NY to Niagara-on-the-Lake, Ontario in 1982-1983(1). 1-Tetradecanol was detected in atmospheric samples at 1.4 ng/cu m and 1.1 ng/cu m in Bakersfield and Fresno, CA, respectively(2).|RURAL/REMOTE: 1-Tetradecanol was detected at 0.6 ng/cu m in air samples from Kern Wildlife Refuge, CA(1).

1-Tetradecanol is an ingredient found in some baby and body lotion products(1).

Toxicity

IDENTIFICATION AND USE: 1-Tetradecanol is a white solid or crystal used in organic synthesis, plasticizers, antifoaming agent, intermediate, perfume fixative for soaps and cosmetics, wetting agents and detergents, ointments and suppositories, shampoos, toothpaste, cold creams, and specialty cleaning preparations. 1-tetradecanol and 1-dodecanol are also used in combination with the (E, E) -8, 10-dodecadiene-1-ol, (Z)-11-tetradecene-1-yl acetate, and (Z)-9-tetradecene-1-yl acetate as a pheromone confusion mixture for controlling pests on plants, e.g., codling moths and leaf wrappers. In Denmark, the product is used for insect control in apples and pears. It is registered for pesticide use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. 1-Tetradecanol has been tested as experimental medication in controlling the progression of chronic periodontal disease. HUMAN EXPOSURE AND TOXICITY: Thirty-one patients allergic to Hirudoid cream were patch tested with the ingredients. 29 were allergic to the cream base and 16 to one or more components. The most common allergens were for 1-tetradecanol, cetostearyl alcohol, and parabens. It has been stated that 1-tetradecanol should not be patch tested at 10% in petrolatum, but at a lesser concentration, due to irritant properties. ANIMAL STUDIES: It has been reported that 1-tetradecanol causes no skin irritation and slight eye irritation.

The objective of this study was to evaluate the skin permeation enhancement effect and skin irritation of saturated fatty alcohols using melatonin as a model compound. A saturated solution of melatonin in a mixture of water and ethanol (40:60) containing 5% w/v of saturated fatty alcohol was used in the skin permeation studies using Franz diffusion cells. For skin irritation studies, 230 uL of fatty alcohol solution was applied on the dorsal surface of the hairless rats using Hill top chamber. The skin irritation was evaluated by visual scoring method and bioengineering methods such as measurement of transepidermal water loss (TEWL) and skin blood flow. The flux of melatonin across hairless rat skin was found to be dependent on the carbon chain length of the fatty alcohols, with decanol showing the maximum permeation of melatonin. All fatty alcohols increased the TEWL and skin blood flow significantly compared with the vehicle. The fatty alcohols (decanol, undecanol and lauryl alcohol), which showed greater permeation of melatonin, also produced greater TEWL, skin blood flow and erythema. Tridecanol and myristyl alcohol showed lower permeation enhancement effect but caused greater skin irritation. Octanol and nonanol may be the most useful enhancers for the transdermal delivery of melatonin considering their lower skin irritation and a reasonably good permeation enhancement effect. ...

LD50 Rat oral 5 g/kg|LD50 Rabbit dermal >5 g/kg /From table/

1-Tetradecanol emission rates from green leaf composite samples and dead leaves were 51 ug/g and 25 ug/g, respectively(1). Essential oil from the herbal part of Cymocarpum erythracum was 73.1% 1-tetradecanol; plants were collected in Erzincan, Turkey(2).

1-Tetradecanol's production and use in organic synthesis, in plasticizers, as an anti-foam agent, perfume fixative for soaps and cosmetics, wetting agents and detergents, ointments and suppositories, shampoos, toothpaste, cold creams, and specialty cleaning preparations(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 18,197-26,303 in humic acid(2), indicate that 1-tetradecanol is expected to be immobile in soil(SRC). Volatilization of 1-tetradecanol from moist soil surfaces is expected given a Henry's Law constant of 1.04X10-4 atm-cu m/mole(3). However, adsorption to soil is expected to attenuate volatilization(SRC). 1-Tetradecanol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.1X10-4 mm Hg at 25 °C(4). A biodegradation rate constant of 52.5 1/hr in sludge was reported for 1-tetradecanol(5), indicating that biodegradation may be an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), reported Koc values of 23,320-64,060 in suspended solids(2), indicate that 1-tetradecanol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 1.04X10-4 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 17 hours and 10 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 20-55 months if adsorption is considered(5). 1-Tetradecanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(6), an estimated BCF of 190(SRC), from its log Kow of 6.03(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is high(SRC). A biodegradation rate constant of 52.5 1/hr was reported in sludge(9), indicating that biodegradation may be an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-tetradecanol, which has a vapor pressure of 1.1X10-4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-tetradecanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 hours(SRC), calculated from its rate constant of 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 1-Tetradecanol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 1-tetradecanol with photochemically-produced hydroxyl radicals has been estimated as 2.1X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 18 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1-Tetradecanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 1-Tetradecanol does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 190 was calculated in fish for 1-tetradecanol(SRC), using a log Kow of 6.03(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC).

Koc values of 18,197-26,303 were reported for 1-tetradecanol in humic acid(1). According to a classification scheme(2), this Koc range suggests that 1-dodecanol is expected to be immobile in soil. Koc values of 5248-12,882, 19,953-32,256, 23,320-64,060 and 44,136-70,202 were reported for 1-tetradecanol in activated sludge, sediment, suspended solids and suspended solids with activated sludge, respectively(1).

The Henry's Law constant for 1-tetradecanol is reported as 1.04X10-4 atm-cu m/mole(1). This Henry's Law constant indicates that 1-tetradecanol is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 17 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 10 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 20-55 months if adsorption is considered(3). 1-Tetradecanol's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 1-Tetradecanol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.1X10-4 mm Hg(4).

RAIN/SNOW/FOG: Six snow surface sites from three different sampling events from 1985-1991 in the Antarctic were analyzed for the content of 1-tetradecanol; Mt. Crummer, Campbell Glacier, Vegetation Island, Tourmaline Plateau, Mt. Melbourne were all below detection limit and it was detected at 387 ng/L at Carezza Lake(1). Snow surface analysis were done for 1-tetradecanol at seven sites in the Antarctic in 1993/1994 season; Wood Bay at sea level (15 ng/L), Mt Melbourne at 200 meters above sea level (2 ng/L, detection limit), Vegetation Island at 220 meters above sea level (27 ng/L), Mt Melbourne at 600 meters above sea level (4 ng/L), McCarthy Ridge at 790 meters above sea level (3 ng/L), Mt Melbourne at 1130 meters above sea level (5 ng/L) and Hercules Neve at 2960 meters above sea level (23 ng/L)(2). 1-Tetradecanol was detected at 5, 7 and 9 ng/L in subsurface samples from respective depths of 1, 2 and 3 meters at McCarthy Ridge(2). 1-Tetradecanol was detected at 2, 6 and 5 ng/L in subsurface samples taken at Hercules Neve at 1, 2 and 3 meters deep, respectively(2). 1-Tetradecanol was identified in two of eight snow samples taken from Mt Sonnblick in the Austrian Alps at concentrations of 10-11 ug/L(3).

1-Tetradecanol was identified as a volatile component of aroma of cooked (1) and raw beef(2). 1-Tetradecanol has been detected in wine and spirits(3).

According to the 2012 TSCA Inventory Update Reporting data, 6 reporting facilities estimate the number of persons reasonably likely to be exposed in the manufacturing, processing, or use of 1-tetradecanol in the United States may be as low as <10 workers up to the range of 500-999 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 4525 workers (1820 of these are female) were potentially exposed to 1-tetradecanol in the US(1). Occupational exposure to 1-tetradecanol may occur through dermal contact with this compound at workplaces where 1-tetradecanol is produced or used. Monitoring and use data indicate that the general population may be exposed to 1-tetradecanol via inhalation of ambient air, ingestion of food and beverages, and dermal contact with consumer products containing 1-tetradecanol(SRC).

Drug Information

2(?). Thought to have very low toxicity, but definite studies have been not located. 2= slightly toxic: Probable oral lethal dose (humans) 5-15 g/kg, between 1 pint and 1 quart for 70 kg (150 lb) person.

Low toxicity. Overexposure causes some central nervous system depression. Prolonged skin contact causes skin irritation. (USCG, 1999)

INGESTION: induce vomiting and call a doctor; if necessary, support respiration. EYES AND SKIN: flush with copious amounts of water. (USCG, 1999)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Higher alcohols (>3 carbons) and related compounds/|/SRP:/ Basic Treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Higher alcohols (>3 carbons) and related compounds/|/SRP:/ Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques, with a bag-valve-mask device, may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose strip or glucometer readings below 50 mg) and administer 50% dextrose if necessary ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Higher alcohols (>3 carbons) and related compounds/

/HUMAN EXPOSURE STUDIES/ During a two-year period contact allergy to topically applied medicaments in the urban population of Malmo was investigated prospectively by patch testing patients with suspected products and their ingredients as well as with standard allergens. Contact dermatitis to specified medicaments was diagnosed in 40 of 408 patients with a positive patch test, and to standard allergens of medicament nature in a further 123 patients. Medicament contact allergy therefore constituted 40% of all allergies observed. This is equivalent to an annual incidence of 43/100,000. Among responsible products the leading antigens were ethylenediamine, phenylbutazone, myristyl alcohol, chlorocresol and cincocaine. In comparison with patients having other contact allergies the present material of medicament contact allergy was characterized by a rather high mean age (57 years), a higher percentage of males, a higher percentage of lower leg and anogenital dermatitis, and a lower percentage of hand dermatitis. A secondary spread occurred in half the cases of lower leg and anogenital dermatitis.|/HUMAN EXPOSURE STUDIES/ BACKGROUND: Although many allergens in metalworking fluids (MWF) are identified, there are still some MWF components, which are not sufficiently investigated concerning their sensitizing properties. OBJECTIVES: To investigate sensitization to 10 frequently used MWF components, which are not part of the established MWF test series, in metalworkers with suspected occupational dermatitis due to MWF. PATIENTS/METHODS: Oleyl alcohol, myristyl alcohol, dimethylolurea, 4,4'-methylenebis morpholine, imazalil, 1-amino-2-propanol (monoisopropanolamine; MIPA), 2-amino-2-ethyl-1,3-propanediol (AEPD), 2,5-bis(n-octyldithio)-1,3,4-thiadiazole, zinc alkyl dithiophosphate and dibenzyl disulfide have been patch tested in 144 patients. RESULTS: 7 patients reacted positively to the formaldehyde releaser 4,4'-methylenebis morpholine, and 6 of these patients also reacted to formaldehyde and/or other formaldehyde releasers. 4 patients reacted positively to myristyl alcohol tested at 10% petrolatum (pet.). Additionally, 20 doubtful or irritant reactions occurred. 1 patient each reacted positively to oleyl alcohol, MIPA, and AEPD. None of the other test substances mentioned above elicited any clear-cut positive reaction. Patch testing with well-known MWF allergens showed proportions of positive reactions, which were comparable to those from other studies, e.g. 11% to monoethanolamine, 8% to colophonium and 3%-5% to various preservatives. CONCLUSIONS: 4,4'-methylenebis morpholine may be an important MWF allergen, although clinical relevance could not be stated definitely in every case. Myristyl alcohol should not be patch tested at 10% pet., but at a lesser concentration, due to irritant properties.|/CASE REPORTS/ 31 patients allergic to Hirudoid cream were patch tested with the ingredients. 29 were allergic to the cream base and 16 to one or more components. The most common allergens were myristyl alcohol, cetostearyl alcohol and parabens. 14 patients reacted only to the base.

myristyl alcohol

1-Tetradecanol Use and Manufacturing

Methods of Manufacturing

It is formed by the catalytic reduction of myristates.

Uses

As emollient for cold creams, etc., also for making the sulfated alcohol whose sodium salt is applicable as a "wetter" in textiles.


Finishing agents|Intermediates|Commercial and industrial products.|Adhesives and sealant chemicals|Lubricants and lubricant additives


Adhesives and sealants|Agricultural products (non-pesticidal)|Cleaning and furnishing care products|Personal care products|Arts, crafts, and hobby materials|Laundry and dishwashing products

Production

50,000,000 - 100,000,000 lb|250,000,000 - 500,000,000 lb|100,000,000 - 250,000,000 lb|(1986) >10 million-50 million pounds|(1990) >10 million-50 million pounds|(1994) >10 million-50 million pounds|(1998) >50 million-100 million pounds|For more U.S. Production (Complete) data for 1-TETRADECANOL (8 total), please visit the HSDB record page.

Grade: Technical|Available commercially in broad or narrow cuts.|Trade names: AEC Myristyl alcohol; Alfol 14; Cachalot myristyl alcohol M-43; CoChem MA; Lanette 14; Nacol 14-99; Sabonal C14; Unihydag WAX-14|Trade name mixtures: Homulgator 920 G; Homulgator 1330 G; Homulgator 910 G Extra; Montanov 14; Neo PCL SE o/w 2/066280; ProLipid 141; Sabonal C12 14; Unieucerin|For more Formulations/Preparations (Complete) data for 1-TETRADECANOL (13 total), please visit the HSDB record page.

All other basic organic chemical manufacturing|1-Tetradecanol: ACTIVE|Agriculture, forestry, fishing and hunting|Alcohols, C12-15: ACTIVE|Alcohols, C10-16: ACTIVE|Alcohols, C12-16: ACTIVE|Adhesive manufacturing|Alcohols, C>14: ACTIVE|Petroleum lubricating oil and grease manufacturing|Alcohols, C14-15: ACTIVE|Alcohols, C14-22 and C16-22-unsatd.: INACTIVE|Narrow cuts contain, typically 98% C14, broad cuts, 62% C14, 36% C16.|Reported product categories: hair dyes and colors (all types requiring caution statements and patch tests); moisturizing preparations; shaving preparations, misc.; cleansing products (cold creams, cleansing lotions, liquids and pads)|Reported cosmetic categories: makeup bases; personal cleanliness products, misc.; beard softeners ... face, body and hand creams and lotions; moisturizing creams and lotions

EPA Safer Chemical Functional Use Classes -> Fragrances|Safer Chemical Classes -> Green half-circle - The chemical is expected to be of low concern|EPA Safer Chemical Functional Use Classes -> Solvents|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|EPA Safer Chemical Functional Use Classes -> Surfactants|Food additives -> Flavoring Agents|Agrochemicals -> Attractants|Fatty Acyls [FA] -> Fatty alcohols [FA05]|Cosmetics -> Antistatic; Emollient; Emulsifying; Emulsion stabilizing; Foam boosting; Hair conditioning; Skin conditioning; Stabilizing; Viscosity controlling

Flavoring Agents

Computed Properties

Molecular Weight:214.39
XLogP3:6.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:12
Exact Mass:214.229665576
Monoisotopic Mass:214.229665576
Topological Polar Surface Area:20.2
Heavy Atom Count:15
Complexity:102
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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