Lethane

203.30200

203.30

203-985-7

Z8ANL9B54I

3534

2810|2902

DTXSID6024674

LIQUID|Clear brown oil

2930909090

67.55000

2.03398

2-(2-butoxyethoxy)ethyl thiocyanate appears as brownish oil or clear yellow liquid. (NTP, 1992)

0.915-0.930 g/cm³ @ Temp: 25 °C

120-125 °C @ Press: 0.25 Torr

133.3ºC

1.471

SOL IN PETROLEUM OILS

BROWNISH OIL (COMMERCIAL PRODUCT)

Insoluble in water.

Ethers

Isocyanates and thioisocyanates, such as 2-(2-BUTOXYETHOXY)ETHYL THIOCYANATE, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].

III

6.1(b)

UN 2810

10-24/25

S13;S45;S36/S37

T

STABLE AT ORDINARY TEMPERATURES BUT TENDS TO REARRANGE AT HIGHER TEMPERATURES

P210, P233, P240, P241, P242, P243, P264, P270, P280, P301+P310, P302+P352, P303+P361+P353, P312, P321, P322, P330, P361, P363, P370+P378, P403+P235, P405, P501

H226

Flash point data for this chemical are not available. It is probably combustible. (NTP, 1992)|Flammable - 2nd degree, Reactive - 1st degree

|Danger|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P264, P270, P280, P301+P310, P302+P352, P303+P361+P353, P312, P321, P322, P330, P361, P363, P370+P378, P403+P235, P405, and P501|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P210, P233, P240, P241, P242, P243, P260, P264, P270, P273, P280, P301+P310, P302+P352, P303+P361+P353, P309+P311, P312, P321, P322, P330, P361, P363, P370+P378, P391, P403+P235, P405, and P501

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves. RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

LETHANE 384 SHOWED SYNERGISTIC ACTIVITY AGAINST TRIBOLIUM CONFUSUM WITH ORGANCHLORINE, CARBAMATE, & PHOSPHORODITHIOATES INSECTICIDES (DDT, CARBARYL, & AZINPHOSETHYL).

LD50 Rat oral 90 mg/kg

ABSORBED THROUGH INTACT SKIN.

ENZYMES IN LIVER AND PERHAPS OTHER ORGANS ARE KNOWN TO LIBERATE CYANIDE ION FROM ... LETHANE 384. GLUTATHIONE S-TRANSFERASE CATALYZES ATTACK OF REDUCED GLUTATHIONE @ THIOCYANATE SULFUR, RESULTING IN LIBERATION OF HCN, OXIDIZED GLUTATHIONE & MERCAPTAN MOIETY OF THE ORGANOTHIOCYANATE.

SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin and mucous membranes; and central nervous system depression. It causes narcosis in high concentrations. ACUTE/CHRONIC HAZARDS: This chemical is an irritant and can be absorbed through contact with the skin. When heated to decomposition it emits very toxic fumes. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Because cyanide is probably largely responsible for poisoning due to ... Lethane 384 ..., antidotal measures against cyanide should be instituted promptly.

SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 1. INGESTION OF CONCENTRATED SOLN MAY LEAD TO VOMITING BECAUSE OF MUCOSAL IRRITATION. /ALIPHATIC THIOCYANATES/|SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 2. PRINCIPAL SYSTEMIC REACTION IS PROBABLY ... CENTRAL NERVOUS DEPRESSION, INTERRUPTED BY PERIODS OF RESTLESSNESS, HYPERPNEA, TONIC CONVULSIONS. AS JUDGED FROM ANIMAL TESTS, DEPRESSION MAY LAST FOR MANY DAYS. /ALIPHATIC THIOCYANATES/|SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 4. DEATH IS USUALLY DUE TO RESPIRATORY ARREST FROM PARALYSIS OF MEDULLARY CENTERS. ... 5. MASSIVE SKIN CONTAMINATION WITH ORG THIOCYANATES SOLN MAY PRODUCE SYSTEMIC POISONING ... & ... LOCAL IRRITATION & DERMATITIS. /ALIPHATIC THIOCYANATES/|SYMPTOMATOLOGY (LARGELY INFERRED FROM ANIMAL TESTS): 6. IN NONFATAL CASES EVIDENCE OF INJURIES TO LIVER AND KIDNEYS MAY APPEAR. /ALIPHATIC THIOCYANATES/|For more Human Toxicity Excerpts (Complete) data for LETHANE 384 (7 total), please visit the HSDB record page.

lethane

LETHANE IS TRADE NAME OF SYNTHETIC ALIPHATIC THIOCYANATE CONCENTRATES AND IS MARKETED BY ROHM AND HAAS (PHILADELPHIA, PA) AS LETHANE 384, LETHANE 384 SPECIAL, AND LETHANE 60.|LETHANE 384: 50% BY VOL SOLN IN KEROSENE.|COMMERCIAL PRODUCT ... IS MIXTURE WITH PETROLEUM DISTILLATE WHICH CONSTITUTES 47% BY WT OR 50% BY VOL.|LETHANE* 384 SPECIAL (DISCONTINUED) ... CONTAINED BETA-BUTOXY-BETA'-THIOCYANODIETHYL ETHER & BETA-THIOCYANOETHYL ESTERS OF ALIPHATIC ACIDS IN A PETROLEUM DISTILLATE.|53% SOLUTION /LETHANE* 384 REGULAR/

... IT WAS INTRODUCED, IN 1932, BY ROHM & HAAS CO UNDER TRADE NAME 'LETHANE 384' & PROTECTION OF US PATENTS 1,808,893; 2,220,521.|IT IS COMPATIBLE WITH PYRETHRINS, ROTENONE, PIPERONYL BUTOXIDE, CHLORINATED HYDROCARBON AND ORGANOPHOSPHORUS INSECTICIDES.|THESE THIOCYANATES HAVE A RAPID PARALYTIC ACTION TO INSECTS THAT IS CLEARLY ATTRIBUTABLE TO THE ACTION OF THE THIOCYANO GROUP. /ORGANOTHIOCYANATES/|PRODUCTS ARE USUALLY EMPLOYED IN OIL BASE SPRAYS IN CONCN RANGING FROM 2-1/2 TO 5%. SUCH SPRAYS USED ON LIVESTOCK SHOULD BE APPLIED AS LIGHT MIST. ON DAIRY COWS ABOUT 1-2 OUNCES/COW APPLIED AT EACH MILKING WILL PROVIDE GOOD CONTROL OF BLOOD-SUCKING FLIES. /LETHANES/|For more General Manufacturing Information (Complete) data for LETHANE 384 (8 total), please visit the HSDB record page.

IN FLY SPRAYS: TREAT WITH POTASSIUM POLYSULFIDE SOLN; EXTRACT OIL WITH LIGHT PETROLEUM, NEUTRALIZE AQ LAYER WITH SULFURIC ACID, ADD SODIUM SULFITE SOLN & ... COPPER SULFATE SOLN; PASS IN SULFUR DIOXIDE; FILTER OFF PPT CUPROUS THIOCYANATE & DETERMINE NITROGEN ... BY KJELDAHL METHOD.|FOR RESIDUE ANALYSIS, HYDROLYZE TO SODIUM CYANIDE & ESTIMATE COLOR WITH BENZIDINE HYDROCHLORIDE & PYRIDINE.

TISSUE SAMPLE; SPECTROPHOTOMETRY AT 532 NM.

Fire Hazards -> Flammable - 2nd degree, Reactive - 1st degree|INSECTICIDES