1-Dodecanol

186.33

186.33

1738860

203-982-0

178A96NLP2

1765

3724

3077

DTXSID5026918

Leaflets from dilute alcohol|COLORLESS LIQ AT ROOM TEMP; CRYSTALLINE OR FLAKES BELOW 20 °C|Colorless solid|CRYSTALLINE SOLID

29051700

20.2

5.4

APHA: ≤10 Liquid

0.8309 g/cm³ @ Temp: 24 °C

24 °C

259 °C @ Press: 760 Torr

>230 °F

n 20/D 1.442(lit.)

H2O: insoluble

Store below +30°C.

0.1 mm Hg ( 20 °C)

7.4 (vs air)

Oral-Rat LD50: 12800 mg/kg

Combustible in case of open flame, high temperature and strong oxidant; burning emits irritating smoke

4%

CHARACTERISTIC FATTY ODOR; UNPLEASANT AT HIGH CONCN BUT DELICATE & FLORAL ON DILUTION

FATTY, WAXY FLAVOR

2.22e-05 atm-m3/mole|Henry's Law constant = 5.186X10-5 atm-cu m/mol at 25 °C

Congealing point greater than 21 °C; acid value not more than 1|Conversion factor: 1 mg/L= 131.3 ppm; 1 ppm= 7.62 mg/cu m at 25 °C, 760 mm Hg|Liquid molar volume = 0.224405 cu m/kmol|Heat of formation = -4.4426X10+8 J/kmol|For more Other Experimental Properties (Complete) data for 1-DODECANOL (6 total), please visit the HSDB record page.|CONVERSION FACTORS: 1 MG/L= 131.3 PPM; 1 PPM= 7.62 MG/CU M AT 25 °C, 760 MM HG

No rapid reaction with air. No rapid reaction with water.

Alcohols and Polyols

DODECANOL is an alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

527 °F (USCG, 1999)|527 °F (275 °C)|250 °C

-7.3380X10+9 J/kmol

Flammability limits = 0.6 to 5.1 vol%

90.8 kJ/mol at 25 °C

Critical temperature = 721.00 deg K; Critical pressure = 1.9300X10+6 Pa

III

9

UN 3077 9/PG 3

1

38-50-50/53-36/38-36/37/38

61-37/39-29-26-60-36

JR5775000

Xi,N

Warehouse ventilated, low temperature and dry

Stable under normal temperatures and pressures.

P260, P264, P270, P273, P305+P351+P338, P309+P311, P337+P313, P391, P405, P501

H320

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Incompatible materials: Strong oxidizing agents.|...Can react with oxidizing materials.

Lauryl alcohol is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and b) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.|Lauryl alcohol is an indirect food additive for use as a component of adhesives.

USEPA/Office of Prevention, Pesticides and Toxic Substances; Reregistration Eligibility Decision Document - Aliphatic Alcohols, EPA 738-R-07-004 (March 2007). The RED summarizes the risk assessment conclusions and outlines any risk reduction measures necessary for the pesticide to continue to be registered in the U.S.[Available from, as of June 2, 2015: http://www.epa.gov/pesticides/reregistration/status.htm]

Combustible.

|Warning|H319 (85.61%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P273, P280, P305+P351+P338, P337+P313, P391, and P501|Aggregated GHS information provided by 3823 companies from 34 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 33 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H315: Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P391, P403+P233, P405, and P501|H320: Causes eye irritation [Warning Serious eye damage/eye irritation]|P260, P264, P270, P305+P351+P338, P309+P311, P337+P313, P405, and P501

Chemical gloves; chemical goggles (USCG, 1999)|Eye/face protection: Safety glasses with side-shields conforming to EN 166. Use equipment for eye protection tested and approved under appropriate governmetn standards such as NIOSH (US) or EN 166(EU).|Skin protection: Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance wit applicable laws and good laboratory practices. Wash and dry hands.|For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator. For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges...|Chemical gloves; chemical goggles.

Combustible when it is exposed to heat or flame.

Explosive limits , vol% in air: 0.5 - 4.0

Wear self contained breathing apparatus for fire fighting if necessary.|Alcohol foam, carbon dioxide, dry chemical. Water or foam may cause frothing. Water may be ineffective on fire. Cool exposed containers with water.

Accidental Release Measures: ... Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.|Accidental Release Measures: ... Use protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.

Precautions for handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.|SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Liquid will cause burning of the eyes and may irritate the skin.

Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Ventilation. Sweep spilled substance into sealable containers. If liquid: collect leaking liquid in containers. Absorb remaining liquid in inert absorbent. Then store and dispose of according to local regulations.

Cool. Well closed. Store in an area without drain or sewer access. Provision to contain effluent from fire extinguishing.

No indication can be given whether a harmful concentration in the air will be reached.

The substance is irritating to the skin, eyes and possibly the respiratory tract. If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.

NO contact with hot surfaces.

PREVENT GENERATION OF MISTS!

Use ventilation.

Protective gloves.

Wear safety spectacles.

| 3 - Materials that, under emergency conditions, can cause serious or permanent injury.| 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.| 0 - Materials that in themselves are normally stable, even under fire conditions.

1-Dodecanol has been detected in wastewater effluents from non-ferrous metal manufacturing industries and textile mills(1). 1-Dodecanol was qualitatively detected in water samples collected from an advanced waste treatment facility in Orange County, CA on Feb 3, 1976(2). 1-Dodecanol was emitted to the air at a rate of 13 ug/sq m hour from one of 10 cushion poly vinyl floorings installed for 3 days, the emission rate decreased to 7 ug/sq m hour 28 days after installation(3).

URBAN/SUBURBAN: 1-Dodecanol was found at 2.0 and 1.6 ng/cu m in atmospheric samples from Bakersfield and Fresno, CA, respectively(1).|RURAL/REMOTE: 1-Dodecanol was found in California at an atmospheric concentration of 0.9 ng/cu m in the Kern Wildlife Refuge(1).

1-Dodecanol was qualitatively detected in an industrial waste dump located along the Llobregat River in Spain(1). 1-Dodecanol was detected from new carpeting in chamber emission tests(2-3). 1-Dodecanol is an ingredient in some shampoo, soap, body wash, shaving gel and hair coloring products(4).

moderately toxic

IDENTIFICATION AND USE: 1-Dodecanol is used principally as chemical intermediate for salts of n-dodecyl sulfate and foam stabilizer for alcohol sulfate surfactants. It is also used in synthetic detergents, lube additives, pharmaceuticals, rubber, textiles, perfumes, and as a flavoring agent. The substance is practically non-toxic, and is a permitted food additive (GRAS) in both the U.S. and the EU. It is registered for pesticide use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. HUMAN EXPOSURE AND TOXICITY: Contact for 48 hours with 4% 1-dodecanol in petrolatum was not irritating to 25 human volunteers, but marked skin irritation was noted when 25% 1-dodecanol in mineral oil was given in open contact with scarified skin of 5 to 10 volunteers once a day for 3 days. There was no skin sensitization in 25 human volunteers at a concentration of 4% in petrolatum. ANIMAL STUDIES: Aspiration of 0.2 mL of 1-dodecanol produced death among 9 out of 10 rats. The deaths were caused by pulmonary edema rather than cardiac arrest or respiratory failure as with the C3 to C10 alcohols. The lungs were dark red; seven rats died within 7 to 30 min, and two rats died 5 hr or longer after dosing. 1-Dodecanol did not cause developmental or reproductive toxicities when tested in rats at concentrations of 0, 100, 500, 2000 mg/kg /day for 14 days prior to mating. 1-Dodecanol, in the doses administered, had no effect on fetal weight, weight gain, food consumption, and food efficiency in the parental generation. When tested for carcinogenicity, 1-dodecanol showed weak tumor-promoting activity when applied three times a week for 60 weeks to the skin of mice that had previously received an initiating dose of dimethylbenz[a]anthracene. In another study, in 6-8 week old mice, ip injections of dodecanol in 0.1 mL tricaprylin (12.0 g/kg to 30 animals in high dose group, and 2.4 g/kg to 28 animals in low dose group) was administered 3 times weekly for eight weeks. Papillomas developed in 2 of 30 mice after 39 and 49 weeks of treatment. Lung tumors were observed in 2/15 female mice in the high dose group, and in 2/15 males and 3/13 females in the low dose group. 1-Dodecanol was not mutagenic to Salmonella typhimurium in the Ames assay with and without metabolic activation, or to Escherichia coli without metabolic activation. However, it diminished cell mitotic activity and caused structural changes to chromosomes and the mitotic apparatus in Vicia faba after 14 hours exposure. ECOTOXICITY: Although Dodecanol exhibits non-polar CNS depressant toxicity to aquatic organisms of about 1 mg/L, the substance is readily degradable and releases during production, or through diffuse uses of the free alcohol do not give rise to environmental concerns.

Nutritional encephalomalacia induced by lauryl alcohol could be completely prevented by dietary supplementation of dl-alpha-tocopheryl acetate.|IN PRESENCE OF DODECANOL, DEPRESSION OF AMPLITUDE OF COMPD ACTION POTENTIAL BY BUTANOL (30 MMOL) WAS INCR.

LD50 Rat oral 12,800 mg/kg|LC50 Rat inhalation >1050 mg/cu m (138 ppm)|LD50 Guinea pig dermal >8310 mg/kg

/AQUATIC SPECIES/ Although dodecanol exhibits non-polar narcotic toxicity to aquatic organisms of about 1 mg/L, the substance is readily degradable and releases during production, or through diffuse uses of the free alcohol do not give rise to environmental concerns.|/AQUATIC SPECIES/ Five month old Bluegill sunfish (average weight 0.63 grams, length 37 mm) acclimatized to test water for 24 hours prior to testing. Forty-eight hours before initiating the test the fish were taken off feed. Ten fish placed in each test vessel at concentrations of 0, 100, 180, 320, 560 and 1000 mg/L. No mortality was observed at 24, 48, or 96 hour intervals, except in the high dose fish at 96 hours, where mortality was 70%. Behavioral observations made during the test indicated that Bluegill sunfish exposed to 560 mg/L and higher exhibited abnormal surfacing behavior and became quiescent.

1-Dodecanol is reportedly found in oil of Mexican lime and in oil from flowers of Furcrae gigantea(1). 1-Dodecanol emission rates from green leaf composite samples and dead leaves were 96 ug/g and 44 ug/g, respectively(2).

1-Dodecanol's production and use in detergents and soaps, in fragrances, and to a lesser extent in wetting, emulsifying, and foaming agents(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), reported Koc values of 2042-3388 in humic acid(2), indicate that 1-dodecanol is expected to have slight mobility in soil(SRC). Volatilization of 1-dodecanol from moist soil surfaces is expected(SRC) given a Henry's Law constant of 5.19X10-5 atm-cu m/mole(3). However, adsorption to soil is expected to attenuate volatilization(SRC). 1-Dodecanol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.48X10-4 mm Hg at 25 °C(4). Theoretical BOD values using standard 5-day aerobic sewage tests ranged from 20-29.7%(5-7) indicate that biodegradation may be an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), a reported Koc value of 7700 in suspended solids and 2337-11,184 in sediment(2), indicate that 1-dodecanol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 5.19X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 27 hours and 12 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The volatilization half-life from a model pond is about 11 months when adsorption is considered(5). 1-Dodecanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(6), an estimated BCF of 48(SRC), from its log Kow of 5.13(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Theoretical BOD values, using standard 5-day aerobic sewage tests ranged from 20-29.7%(9-11), indicate that biodegradation may be an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-dodecanol, which has a vapor pressure of 8.48X10-4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-dodecanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 21 hours(SRC), calculated from its rate constant of 1.8X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 1-Dodecanol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 1-dodecanol with photochemically-produced hydroxyl radicals has been estimated as 1.8X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 21 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1-Dodecanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 1-Dodecanol does not contain chromophores that absorb at wavelengths >290 nm(2) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 48 was calculated in fish for 1-dodecanol(SRC), using a log Kow of 5.13(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

3.31e+03 L/kg|Koc values of 2042-3388 were reported for 1-dodecanol in humic acid(1). According to a classification scheme(2), this Koc range suggests that 1-dodecanol is expected to have slight mobility in soil. Koc values of 2570-6574, 2337-11,184, 7700 and 16,700-17,981 were reported for 1-dodecanol in activated sludge, sediment, suspended solids and suspended solids with activated sludge, respectively(1).

The Henry's Law constant for 1-dodecanol is reported as 5.19X10-5 atm-cu m/mole(1). This Henry's Law constant indicates that 1-dodecanol is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 27 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 12 days(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The volatilization half-life from a model pond is about 11 months when adsorption is considered(3). 1-Dodecanol's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 1-Dodecanol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.48X10-4 mm Hg(4).

GROUND WATER: 1-Dodecanol was qualitatively detected in well waters collected from wells in the vicinity of an industrial waste dump located along the Llobregat River in Spain(1); it was thought that its presence in the well water was a result of leaching from the waste dump(1). 1-Dodecanol has been detected in ground water samples collected in the United Kingdom (collection dates, sites and concentrations not reported)(2).|DRINKING WATER: 1-Dodecanol was qualitatively detected in drinking water samples collected from New Orleans, LA (Jan 1976), Philadelphia, PA (Feb 1976), and Seattle, WA (Nov 1976)(1).|SURFACE WATERS: 1-Dodecanol was qualitatively detected in water samples taken from Lakes Erie, Michigan, Superior, and St. Clair(1). 1-Dodecanol was qualitatively detected in surface water samples taken from Lake Pontchartrain (LA) in the spring of 1976(2).|RAIN/SNOW/FOG: Six snow surface sites from three different sampling events from 1985-1991 in the Antarctic were analyzed for the content of 1-dodecanol; Mt. Crummer, Campbell Glacier, Vegetation Island, Tourmaline Plateau, Mt. Melbourne were all below detection limit and Carezza Lake was found at 203 ng/L(1). Two sites were analyzed at different snow depths; Styx Glacier (surface 232 ng/L, 1 meter deep 2350 ng/L, 2 meters deep 650 ng/L) and McCarthy Ridge (surface 511 ng/L, 1 meter deep 107 ng/L, 2 meters deep 134 ng/L)(1). Snow surface analysis were done on seven sites in the Antarctic in 1993/1994 season; Wood Bay at sea level (8 ng/L), Mt Melbourne at 200 meters above sea level (below detection limit), Vegetation Island at 220 meters above sea level (28 ng/L), Mt Melbourne at 600 meters above sea level (4 ng/L), McCarthy Ridge at 790 meters above sea level (7 ng/L), Mt Melbourne at 1130 meters above sea level (8 ng/L) and Hercules Neve at 2960 meters above sea level (18 ng/L)(2). 1-Dodecanol was detected a 8, 12 and 2 ng/L at the depths of 1, 2 and 3 meters, respectively in subsurface snow samples at McCarthy Ridge(2). 1-Dodecanol was detected at 4 ng/L at the depth of 1 meter and was below detection limit at 2 and 3 meters deep in subsurface snow samples taken at Hercules Neve(2). 1-Dodecanol was identified in four of eight snow samples taken from Mt Sonnblick in the Austrian Alps at concentrations of 9-16 ug/L(3).

1-Dodecanol was qualitatively detected as a volatile flavor component of Idaho Russet Burbank baked potatoes(1) and in beef(2). 1-Dodecanol has been detected in beer, wine and spirits(3).

According to the 2012 TSCA Inventory Update Reporting data, 7 reporting facilities estimate the number of persons reasonably likely to be exposed in the manufacturing, processing, or use of 1-dodecanol in the United States may be as low as <10 workers up to the range of 500-999 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 58,100 workers (20,007 of these are female) were potentially exposed to 1-dodecanol in the US(1). Occupational exposure to 1-dodecanol may occur through dermal contact with this compound at workplaces where 1-dodecanol is produced or used. Monitoring data indicate that the general population may be exposed to 1-dodecanol via inhalation of ambient air, ingestion of food and drinking water, and dermal contact with consumer products containing 1-dodecanol(SRC).

1-Dodecanol was qualitatively detected in expired air of humans having diabetic conditions(1); it was not detected (detection limit not reported) in expired air of non-diabetic humans(1).

2(?)= slightly toxic: Probable oral lethal dose (human) 5-15 g/kg; between 1 pint and 1 quart for 70 kg person (150 lbs.) (?)= toxicity ratings followed by interrogation points are based on obviously inadequate data; some represent no more than guesses.

After 24-hr covered contact with the skin of mice, about 95% of a 100-uL dose of 0.5% 1-dodecanol in triethyl citrate remained on the skin. A small proportion, 0.1%, was recovered in the feces and urine, 0.13% was recovered from the body, and 2.61% was excreted in the air. These data indicate a low amount of dermal uptake.

Frog liver microsomes catalyzed the hydroxylation of 1-dodecanol into the corresponding omega- and (omega-1)-hydroxy derivatives. The hydroxylation rate for 1-dodecanol was much lower than that for lauric acid. Both NADPH and O2 were required for hydroxylation activity. NADH had no effect on the hydroxylation. The hydroxylating system was inhibited 49% by CO at a CO:O2 ratio of 4.0. The formation of omega-hydroxydodecanol was more sharply inhibited by CO than was the formation of (omega-1)-hydroxydodecanol, implying that more than one cytochrome P-450 was involved in the hydroxylation of 1-dodecanol and that CO has a higher affinity for the P-450 catalyzing the omega-hydroxylation. The formation of laurate during the incubation of 1-dodecanol with frog liver microsomes suggests that a fatty alcohol oxidation system is also present in the microsomes. NAD+ was the most effective cofactor for the oxidation of 1-dodecanol and NADP+ had a little effect. Pyrazole (an inhibitor of alcohol dehydrogenase) had a slight inhibitory effect on the oxidation and sodium azide (an inhibitor of catalase) had no effect.|The liver microsomes of the Mongolian gerbil Meriones unguiculatus catalyzed the hydroxylation of various saturated fatty acids (C8-C18), alcohols (C12 and C16) and hydrocarbon (C12) to the corresponding omega- and (omega-1)-hydroxy derivatives. Lauric acid was hydroxylated most effectively among saturated fatty acids and the order of activity as hydroxylation substrates was C12 greater than C14 greater than C13 greater than C16 greater than C10 greater than C18 greater than C8. The specific activity of laurate hydroxylation (5.99 nmol/mg microsomal protein/min) in gerbil liver microsomes was higher than that observed in other species. 1-Dodecanol was also hydroxylated very effectively (4.58 nmol/mg microsomal protein/min) by gerbil liver microsomes, but in general the hydroxylation rates for fatty alcohols were much lower than those for the corresponding acids.

Liquid will cause burning of the eyes and may irritate skin. (USCG, 1999)

SKIN OR EYES: wash exposed areas with water. (USCG, 1999)

Fresh air, rest. Seek medical attention if you feel unwell.

Remove contaminated clothes. Rinse and then wash skin with water and soap.

Rinse with plenty of water for several minutes (remove contact lenses if easily possible).

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Higher alcohols (>3 carbons) and related compounds/|/SRP:/ Basic Treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Higher alcohols (>3 carbons) and related compounds/|/SRP:/ Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques, with a bag-valve-mask device, may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose strip or glucometer readings below 50 mg) and administer 50% dextrose if necessary ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Higher alcohols (>3 carbons) and related compounds/

/HUMAN EXPOSURE STUDIES/ A 48-hr contact with 4% 1-dodecanol in petrolatum was not irritating to 25 human volunteers, but marked skin irritation was noted when 25% 1-dodecanol in mineral oil was given in open contact with scarified skin of 5 to 10 volunteers once a day for 3 days. There was no skin sensitization in 25 human volunteers at a concentration of 4% in petrolatum.

1 Dodecanol

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Cough. Sore throat.

Redness.

Redness. Pain.

Use as a chemical intermediate for n-dodecyl sulfate salts is believed to consume the largest quantity of 1-dodecanol; production of ethoxylated 1-dodecanol is probably the next largest market (1976)|In the U.S.A. approximately 20,000 lbs/year are used in fragrances, and some typical concentrations reported in personal care products include soaps (0.01 - 0.09%), detergents (0.002 - 0.018%), lotions and creams (0.005 - 0.02%) and perfumes (0.09 - 0.25%).

Grades: Technical, Food Chemical Codex|Royaltac-M (Macdermid Agricultural Solutions, Inc.): Active ingredient: lauryl alcohol 0.3%; 1-octanol 36.2%; 1-decanol 48.2%.|Off-Shoot-T (Macdermid Agricultural Solutions, Inc.): Active ingredient: lauryl alcohol 0.3%; 1-octanol 36.2%; 1-decanol 48.2%.|C8-C10 Fatty Alcohol Technical (Macdermid Agricultural Solutions, Inc.): Active ingredient: lauryl alcohol 0.3%; 1-octanol 42.6%; 1-decanol 56.7%.|For more Formulations/Preparations (Complete) data for 1-DODECANOL (17 total), please visit the HSDB record page.|TECHNICAL & F.C.C

All other basic organic chemical manufacturing|1-Dodecanol: ACTIVE|Dodecanol: ACTIVE|Alcohols, C8-18: ACTIVE|... 1-dodecanol (PC code 001509), was first registered for use as a Lepidopteran pheromone/sex attractant in 1993.

EPA Safer Chemical Functional Use Classes -> Fragrances;Solvents|Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern|Food additives -> Flavoring Agents|Agrochemicals -> Attractants|Flavoring Agents -> JECFA Flavorings Index|Fatty Acyls [FA] -> Fatty alcohols [FA05]|Cosmetics -> Emollient; Emulsifying; Emulsion stabilizing; Viscosity controlling

Flavoring Agents