Ponceau 4R

604.47

603.926880

220-036-2

Z525CBK9PG

DTXSID9021213

Maroon powder

32041200

242

6.06870

Bordeaux to brown Powder

0.13 M

Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

LD50 oral in rat: > 8gm/kg

NONH for all modes of transport

2

22-24/25

QJ6530000

Stable under normal temperatures and pressures.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|A BIOCHEMICAL DEGRADATION TEST OF FOOD COAL-TAR DYES USING SLUDGE EVALUATED THEIR DISPOSAL SAFETY. FOOD RED NUMBER 102 WAS ONE OF 4 AZO DYES READILY DECOMPOSED UNDER ANAEROBIC CONDITIONS. PRODUCTS OF THESE AZO DYES DECOMPOSED BY SLUDGE UNDER ANAEROBIC CONDITIONS WERE IDENTIFIED AS SULFONILIC, NAPHTHIONIC ACIDS, ETC.

Not Classified

RED NUMBER 102 (NEW COCCINE, NC) CAUSED SEVERE GROWTH RETARDATION WHEN ADDED TO A BASAL PURIFIED, LOW-FIBER DIET (25% CASEIN-SUCROSE) AT 5% LEVEL. THE CONCURRENT ADDITION OF DIETARY FIBER (GDF) FROM GOBO, THE ROOTS OF EDIBLE BURDOCK (ARCTIUM LAPPA L), COMPLETELY PROTECTED AGAINST THE TOXICITY OF NEW COCCINE.

C.I. Acid Red 18's production and use as an important textile dye for wool, nylon and silk, or as a dye for inks, for dyeing paper and leather, coloring plastics and staining wood(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 9(SRC), determined from an experimental water solubility(2) and a recommended regression-derived equation(3), indicates that C.I. Acid Red 18 will have very high mobility in soil(SRC). However, the retention of C.I. Acid Red 18 by ion-exchange processes(7,SRC), particularly on clay surfaces, and adsorption at mineral surfaces such as geothite(9), may slow down or prevent leaching(SRC). Based on limited data, C.I. Acid Red 18 is expected to be resistant to aerobic biodegradation(4,5); it may be biodegraded anaerobically as a wide variety of anaerobic bacteria have the ability to cleave the azo linkage to produce aromatic amines(6). Since C.I. Acid Red 18 is an ionic compound, volatilization from moist soil surfaces will not be important(7,SRC). On surface soils exposed to sunlight, C.I. Acid Red 18 may slowly photolyze(8).|AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 9(SRC), determined from a measured water solubility(2,SRC) and a recommended regression-derived equation(1), indicates that C.I. Acid Red 18 is not expected to adsorb to suspended solids and sediment in the water(SRC). However, the retention of C.I. Acid Red 18 by ion-exchange processes(7,SRC), particularly on clay surfaces, and adsorption at mineral surfaces such as geothite(9), may slow down or prevent leaching(SRC). C.I. Acid Red 18 is expected to be resistant to aerobic biodegradation(3,4); it may biodegrade anaerobically as a wide variety of anaerobic bacteria have the ability to cleave the azo linkage to produce aromatic amines(5). C.I. Acid Red 18 may be susceptible to slow photolysis in water(SRC) with an estimated half-life of 133 days(6). Since C.I. Acid Red 18 is an ionic compound, volatilization from water surfaces will not be important(7,SRC). An estimated BCF value of 1(1,SRC), from a measured water solubility(2), suggests that C.I. Acid Red 18 will not bioconcentrate in aquatic organisms(SRC), according to a recommended classification scheme(8).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), C.I. Acid Red 18, with an estimated vapor pressure of 1.3X10-27 mm Hg at 25 °C(2), should exist solely in the particulate phase in the ambient atmosphere. Particulate-phase C.I. Acid Red 18 may be physically removed from the air by wet and dry deposition(SRC).

Based on an experimentally determined first order rate constant of 0.00522 1/day, the half-life of C.I. Acid Red 18 in distilled water exposed to sunlight can be estimated to be approximately 133 days(1,SRC). C.I. Acid Red did not precipitate in water with a calcium concentration of 10-3 M(1).

An estimated BCF value of 1.0 was calculated for C.I. Acid Red 18(SRC), using a measured water solubility of 80,000 mg/l(1) and a recommended regression-derived equation(2). According to a recommended classification scheme(3), this BCF value suggests that bioconcentration of C.I. Acid Red 18 in aquatic organisms will not be an important fate process(SRC).

In an activated sludge process system dosed with 1 ppm and 5 ppm, only 1% C.I. Acid Red 18 was adsorbed over a period of 27 days(1) suggesting that this compound may be mobile in soil(SRC). However, the retention of C.I. Acid Red 18 by ion-exchange processes(5,SRC), particularly on clay surfaces, and adsorption at mineral surfaces such as geothite(6), may slow down or prevent leaching(SRC). The Koc of C.I. Acid Red 18 is estimated as approximately 9(SRC), using an experimental water solubility of 80,000 mg/l(2) and a regression-derived equation(3,SRC). According to a recommended classification scheme(4), the estimated Koc value of 9 suggests that C.I. Acid Red 18 has very high mobility in soil(SRC).

Since C.I. Acid Red 18 is an ionic compound, volatilization from water and moist soil surfaces will not be important(1,SRC).

NIOSH (NOHS Survey 1972-1974) has statistically estimated that 138 workers are potentially exposed to C.I. Acid Red 18 in the USA(1). NIOSH (NOES Survey 1981-1983) has statistically estimated that 8,249 workers (2,006 of these are female) are potentially exposed to C.I. Acid Red 18 in the USA(2).

Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS. (See all compounds classified as Coloring Agents.)

THE BILIARY EXCRETION RATES OF NEW COCCINE 50-100 UMOLE ADMINISTERED IV TO RATS WITH LIGATED RENAL PEDICLES, REACHED APPARENT MAXIMA WHICH WERE DEPRESSED BY PHENOLPHTHALEIN GLUCURONIDE OR PROBENECID (BOTH 50 UMOLE). BILIARY EXCRETION MAY INVOLVE AN ACTIVE TRANSPORT PROCESS.

SOME PATIENTS WHO SUFFER FROM ASTHMA, RHINITIS OR URTICARIA UNDERGO EXACERBATION OF SYMPTOMS FOLLOWING INGESTION OF FOODS OR BEVERAGES CONTAINING AZO DYES. THESE PATIENTS MAY BE MISTAKENLY THOUGHT TO BE SUFFERING FROM SPECIFIC FOOD ALLERGIES. DRUGS & THEIR COATINGS MAY CONTAIN AZO DYES & THESE SHOULD BE AVOIDED BY PATIENTS ON AN ADDITIVE-FREE DIET. /AZO DYES/

1,3-naphthalenedisulfonic acid, 7-hydroxy-8-((4-sulfo-1-naphthalenyl azo) trisodium salt)

1,3-Naphthalenedisulfonic acid, 7-hydroxy-8-[2-(4-sulfo-1-naphthalenyl)diazenyl]-, sodium salt (1:3): ACTIVE

IDENTIFICATION OF FOOD DYES BY THIN-LAYER CHROMATOGRAPHY.|FOOD DYES SEPARATED & IDENTIFIED BY THIN LAYER AND COLUMN CHROMATOGRAPHY.|IDENTIFICATION OF DYES BY MEANS OF THIN LAYER, PAPER, & HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY.|FOOD DYES IDENTIFIED BY HIGH PRESSURE LIQUID CHROMATOGRAPHY.

Food additives|Cosmetics -> Cosmetic colorant; Hair dyeing

Food Additives -> COLOUR;