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Piperlongumine

Piperlongumine structure

CAS No:
20069-09-4
Formula:
C17H19NO5
Chemical Name:
Piperlongumine
Synonyms:
2(1H)-Pyridinone,5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-;2(1H)-Pyridone,5,6-dihydro-1-(3,4,5-trimethoxycinnamoyl)-;2(1H)-Pyridinone,5,6-dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-,(E)-;2(1H)-Pyridinone,5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-;5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone;Piperlongumine;Piplartine;Piplartin;2859-00-9;11042-67-4;25343-05-9
Categories:
Cosmetic Ingredient > Bleaching Agent

Description

Piperlongumine is a natural alkaloid isolated from Piper longum Linn[1], possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities[2]. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines[1]. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway[2].

Solid

Piplartine is a member of cinnamamides and a dicarboximide.

Piperlongumine Basic Attributes

Molecular Weight：

317.34

Exact Mass：

317.34

UNII：

SGD66V4SVJ

HScode：

2933399090

Characteristics

PSA：

65.1

XLogP3：

2.1

Appearance：

white to beige

Density：

1.2±0.1 g/cm3

Melting Point：

124 °C

Boiling Point：

475.6ºC at 760mmHg

Flash Point：

241.4±28.7 °C

Refractive Index：

1.581

Water Solubility：

DMSO: ≥5mg/mL at warmed to 60°C

Storage Conditions：

2-8°C

Collision Cross Section：

176.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

RTECS Number：

UU7785850

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

Piperlongumine

Piperlongumine Use and Manufacturing

anti-asthma, antibronchitis

Computed Properties

Molecular Weight:317.34
XLogP3:2.1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:317.12632271
Monoisotopic Mass:317.12632271
Topological Polar Surface Area:65.1
Heavy Atom Count:23
Complexity:473
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Related Drugs

Berberis bark capsule
Ingredients	Berberis bark, Piper splendens, Emblica officinalis, Licorice, Safflower, Bear Bile, Musk, and Chinese ink.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each tablet contains 0.3g
Manufacturer	Qinghai Jiumei Tibetun Mtaicine PhatmaCeuticd Co., Ltd.

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Guide of Piperlongumine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Related Drugs
Recommended Suppliers
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Piperlongumine

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