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Guanidine hydrochloride

Guanidine hydrochloride structure

CAS No:
50-01-1
Formula:
CH5N3.ClH
Chemical Name:
Guanidine hydrochloride
Synonyms:
Guanidine,hydrochloride (1:1);Guanidine,monohydrochloride;Guanidinium chloride;Guanidine chloride;Guanidinium hydrochloride;Guanidine hydrochloride;Buffer AL;420-13-3;14317-32-9;15827-40-4;87667-20-7;94369-44-5;106946-18-3;139693-44-0;143504-22-7;915070-50-7;1340579-42-1
Categories:
Cosmetic Ingredient > Buffering

Description

Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.Target: OthersGuanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the mo

DryPowder; DryPowder, Liquid|HYGROSCOPIC CRYSTALLINE POWDER.

Guanidine Hydrochloride is the hydrochloride salt form of guanidine, a strong basic compound with parasympathomimetic activity. Guanidine hydrochloride enhances the release of acetylcholine following a nerve impulse and potentiates acetylcholine actions on muscarinic and nicotinic receptors. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes. (NCI05)|A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.

Guanidine hydrochloride Basic Attributes

Molecular Weight：

95.53140

Exact Mass：

95.02500

EC Number：

200-002-3

UNII：

3YQC9ZY4YB

ICSC Number：

0894

NSC Number：

755884

DSSTox ID：

DTXSID7058757

NCI Thesaurus Code：

C47551

HScode：

2925290090

Characteristics

PSA：

75.89000

XLogP3：

-1.7

Appearance：

DryPowder; DryPowder, Liquid

Density：

1.3 g/cm³

Melting Point：

178 °C

Boiling Point：

132.9ºC at 760 mmHg

Flash Point：

34.2ºC

Refractive Index：

n20/D 1.465

Water Solubility：

H2O: 2280 g/L (20 ºC)

Storage Conditions：

Store at RT.

Toxicity：

LD50 orally in Rabbit: 655.3 - 907.1 mg/kg LD50 dermal Rabbit > 2000 mg/kg

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R22; R36/38

safety instructions：

S22

RTECS Number：

MF4300000

Marks：

Storage features：

Well closed. Dry.

Stability/Shelf Life：

Stable. Hygroscopic. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P261-P280-P301 + P312 + P330-P304 + P340 + P312-P305 + P351 + P338-P337 + P313

Hazard Statements：

H302 + H332-H315-H319

Fire Hazards：

Combustible.

GHS Classification：

|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, and P501|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|Aggregated GHS information provided by 380 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fire Fighting：

Use foam, powder.

Spillage Disposal：

Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Personal protection: P2 filter respirator for harmful particles.

Safe Storage：

Well closed. Dry.

Inhalation Risk：

Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.

Effects of Short Term Exposure：

The substance is irritating to the eyes and skin.

Fire Prevention：

NO open flames.

Exposure Prevention：

PREVENT DISPERSION OF DUST!

Inhalation Prevention：

Use local exhaust or breathing protection.

Skin Prevention：

Protective gloves. Protective clothing.

Eye Prevention：

Wear safety goggles or eye protection in combination with breathing protection.

Drug Information

First Aid：

Fresh air, rest.

Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

MeSH Entry Terms：

Chloride, Guanidinium

Exposure Routes：

The substance can be absorbed into the body by ingestion.

Symptoms：

Cough.

Redness.

Redness. Pain.

Guanidine hydrochloride Use and Manufacturing

Uses

Used in organic synthesis and pharmaceutical industry; mainly used as intermediates for medicines, important raw materials for the manufacture of sulfadiazine, sulfamethazine, sulfamethazine and folic acid; used as intermediates in medicine, pesticides, dyes and other organic synthesis body. It can be used to synthesize 2-aminopyrimidine, 2-amino-6-methylpyrimidine, 2-amino-4,6-dimethylpyrimidine, and is used to manufacture sulfadiazine, sulfamethazine, sulfamethazine and other sulfa drugs Intermediate. Guanidine hydrochloride (or guanidine nitrate) reacts with ethyl cyanoacetate to form 2,4-diamino-6-hydroxypyrimidine, which is used to synthesize folic acid, an anti-anemia drug. It can also be used as an antistatic agent for synthetic fibers. Used as an organic synthesis intermediate; used as an antistatic agent for synthetic fibers; a powerful chaotropic agent, used for protein denaturation and subsequent refolding

Flame retardants

Personal care products

Production

100,000 - 500,000 lb

Manufacturing Info：

Metal treatment|Guanidine, hydrochloride (1:1): ACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Cosmetics -> Buffering

Computed Properties

Molecular Weight:95.53
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:1
Exact Mass:95.0250249
Monoisotopic Mass:95.0250249
Topological Polar Surface Area:75.9
Heavy Atom Count:5
Complexity:26.3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Ammonium chloride

Carbon tetrachloride

Urea

Ammonia

Downstream Products

Benzoic acid

Acetone

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Guide of Guanidine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Downstream Products
Recommended Suppliers
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Guanidine hydrochloride

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