1,1,1-Trichloro-2,2,2-trifluoroethane

187.38

187.38

206-564-6

07H0R79HO0

DTXSID5027148

Colorless gas

2903772012

0

3.30

Liquid

1.5790 g/cm³ @ Temp: 20 °C

14.2 °C

46.1 °C

None

1.385

Solubility in water, g/100ml at 20°C: 0.02

Vapour pressure, kPa at 20°C: 36

Relative vapour density (air = 1): 6.5

LC50 ihl-rat: 13 pph/15M HUTODJ 1,239,82

Expected to be nearly odorless

Henry's Law constant = 0.267 atm-cu m/mol at 25 °C (est)

Ozone-depleting potential: 0.8|Global Warming Potential = 5000

1256 °F

IRRITANT, OZONE DEPLETER

3082

59-36/37/38

23-24/25-61-59-36/37/39-26

KJ3975000

Xi,N

Separated from metals and alloys. See Chemical Dangers. Cool. Ventilation along the floor.

Irritant

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

The Food and Drug Administration (FDA), after consultation with the Environmental Protection Agency (EPA), is amending FDA's regulation on the use of ozone-depleting substances (ODSs) in selfpressurized containers to remove the essential-use designations for flunisolide, triamcinolone, metaproterenol, pirbuterol, albuterol and ipratropium in combination, cromolyn, and nedocromil used in oral pressurized metered-dose inhalers (MDIs). The Clean Air Act requires FDA, in consultation with the EPA, to determine whether an FDA-regulated product that releases an ODS is an essential use of the ODS. FDA has concluded that there are no substantial technical barriers to formulating flunisolide, triamcinolone, metaproterenol, pirbuterol, albuterol and ipratropium in combination, cromolyn, and nedocromil as products that do not release ODSs, and therefore they will no longer be essential uses of ODSs as of the effective dates of this rule. MDIs for these active moieties containing an ODS may not be marketed after the relevant effective date. DATES: Removal of Part 2.125(e)(2)(iii) and 2.125(e)(4)(vii) is effective June 14, 2010. Removal of Part 2.125(e)(1)(v) and 2.125(e)(4)(iv) is effective December 31, 2010. Removal of Part 2.125(e)(1)(iii) is effective June 30, 2011. Removal of 2.125(e)(2)(iv) and Part 2.125(e)(4)(viii) is effective December 31, 2013. /Ozone-Depleting Substances/|Use of ozone-depleting substances in foods, drugs, devices, or cosmetics. (a) As used in this section, ozone-depleting substance (ODS) means any class I substance as defined in 40 CFR part 82, appendix A to subpart A, or class II substance as defined in 40 CFR part 82, appendix B to subpart A. (b) Except as provided in paragraph (c) of this section, any food, drug, device, or cosmetic that is, consists in part of, or is contained in an aerosol product or other pressurized dispenser that releases an ODS is not an essential use of the ODS under the Clean Air Act. (c) A food, drug, device, or cosmetic that is, consists in part of, or is contained in an aerosol product or other pressurized dispenser that releases an ODS is an essential use of the ODS under the Clean Air Act if paragraph (e) of this section specifies the use of that product as essential. For drugs, including biologics and animal drugs, and for devices, an investigational application or an approved marketing application must be in effect, as applicable. ... (e) The use of ODSs in the following products is essential: ... (2) Metered-dose short-acting adrenergic bronchodilator human drugs for oral inhalation. Oral pressurized metered-dose inhalers containing the following active moieties: ... (iv) Pirbuterol. ... (4) Other essential uses. (iii) Anesthetic drugs for topical use on accessible mucous membranes of humans where a cannula is used for application. ... (vi) Metered-dose atropine sulfate aerosol human drugs administered by oral inhalation. ... (viii) Metered-dose ipratropium bromide and albuterol sulfate, in combination, administered by oral inhalation for human use. (ix) Sterile aerosol talc administered intrapleurally by thoracoscopy for human use. /Ozone-Depleting Substances/

Production and Consumption of Ozone Depleting Substances under the Montreal Protocol 1986 - 2004[UNEP; Ozone Secretariat UNEP November 2005, Available from, as of march 11, 2013: http://ozone.unep.org/Publications/Production_and_consumption2005.pdf]|The Montreal Protocol on Substances that Deplete the Ozone Layer[UNEP; Ozone Secretariat United Nations Environment Programme, The Montreal Protocol on Substances that Deplete the Ozone Layer, Available from, as of March 11, 2013: http://ozone.unep.org/pdfs/Montreal-Protocol2000.pdf]|Achievements in Stratospheric Ozone Protection Progress Report: This report covers the important and substantial achievements of the people, programs, and organizations that are working to protect the Earth's ozone layer. As impressive as these accomplishments are, our work is not done. Even though we have reduced or eliminated the use of many ozone-depleting substances, some still remain. Additionally, since ozone-depleting substances persist in the air for long periods of time, the past use of these substances continues to affect the ozone layer today. We must also continue to ensure that the alternatives being brought to the market support the country's long-term environmental goals in a cost-effective manner.[EPA; Achievements in Stratospheric Ozone Protection Progress Report, Available from, as of March 11, 2013: http://www.epa.gov/ozone/downloads/spd-annual-report_final.pdf]|UNEP; Ozone Secretariat. Twenty Questions and Answers about the Ozone Layer: 2010 Update. The questions address the nature of atmospheric ozone, the chemicals that cause ozone depletion, how global and polar ozone depletion occur, the success of the Montreal Protocol, and what could lie ahead for the ozone layer.[Available from, as of May 21, 2013: http://ozone.unep.org/Assessment_Panels/SAP/Scientific_Assessment_2010/]|USEPA; Ozone Layer Protection - Alternatives/SNAP Program. List of Substitutes. Substitutes are reviewed on the basis of ozone depletion potential, global warming potential, toxicity, flammability, and exposure potential as described in the final SNAP rule (59 FR 13044). Lists of acceptable and unacceptable substitutes are updated several times each year.[Available from, as of May 21, 2013: www.epa.gov/ozone/snap/lists/index.html]

Forced air ventilation and level of vapor concentration together with the use of individual breathing devices with independent air supply will minimize risk of inhalation. Lifelines should be worn when entering tanks or other confined spaces. /Chlorofluorocarbon/|Neoprene gloves, protective clothing, and eye protection minimize risk of topical contact. /Chlorofluorocarbon or Hydrochlorofluorocarbon/

Very slight, when exposed to heat or flame.

Inhalation of vapors should be avoided. /Chlorofluorocarbon/|Forced air ventilation at the level of vapor concentration together with the use of individual breathing devices with independent air supply will minimize the risk of inhalation. Lifelines should be worn when entering tanks or other confined spaces. /Chlorofluorocarbon/|Enclosure of process materials and isolation of reaction vessels and proper design and operation of filling heads for packaging and shipping ... /are administrative controls that may be instituted to limit occupational exposure to chlorofluorocarbons during manufacture, packaging, and use/. /Chlorofluorocarbon/|Filling areas should be monitored to ensure that the ambient CFC, /and/ HCFC ... /concentration does/ not exceed prevailing work standards. /Chlorofluorocarbon/|SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.

1,1,1-Trichloro-2,2,2-trifluoroethane was detected as a component of landfill gases from sites in the UK at a measured concentration of 70 mg/cu-m in underground probes(1). 1,1,1-Trichloro-2,2,2-trifluoroethane was detected, not quantified at hazardous waste sites and a sanitary landfill in New Jersey(2).

SEDIMENT: Trichlorotrifluoroethanes were detected in sediment samples at the site of an illegal dump site, The Valley of the Drums, KY, 1979 at a concentration of 5.4 mg/L(1). /Trichlorofluoroethanes/

RURAL/REMOTE: 1,1,1-Trichloro-2,2,2-trifluoroethane was qualitatively detected in rural air samples, date and location not provided(1). The concentration of 1,1,1-trichloro-2,2,2-trifluoroethane in air samples collected at the South Pole, January 1985, was 11 ppb(2).

LC50 Rat inhalation 13 parts per hundred (pph)/ 15 minutes|LD50 Mouse ip 8600 mg/kg

The National Cancer Institute and National Toxicology Program have performed 2-year toxicology and carcinogenesis studies with a number of ethanes substituted with chlorine or bromine. A review of the results of studies with these halogenated ethanes has revealed several consistencies between the pattern of halogen substitution and neoplastic responses in some affected organs. One of these consistencies was the finding of a modest increase in the incidence of renal tubule cell neoplasms in male rats administered penta- or hexachloroethane. Certain aspects of the nephropathy also noted in these studies resembled what is now recognized as a distinct hyaline droplet nephropathy typically associated with the accumulation of alpha2u-globulin in renal tubule cells. In an attempt to determine some of the structure activity relationships involved in the induction of hyaline droplet nephropathy by halogenated ethanes, a series of commercially available ethanes substituted with three or more chlorines, four or more bromines, or a combination of chlorines and fluorines was studied in a short-term renal toxicity assessment in male F344/N rats...Groups of five male rats were administered the vehicle (corn oil) or 0.62 or 1.24 mmol/kg 1,1,2,2-TC-1,2-DFE ... by gavage in a corn oil vehicle (5 mL/kg bod y weight) 7 days a week for 3 weeks. Additionally, five male and five female rats received the corn oil vehicle only, and five females designated as negative controls were administered 1.24 mmol/kg PCE...Necropsies were performed on all rats that survived to the end of the study and on four rat s administered 0.62 mmol/kg 1,1,2,2-TBE that died early. The right kidney, liver, and right testis were weighed...All male rats administered 1,1,1-TriC-2,2,2-TFE survived until the end of the study. The final mean body weights and mean body weight gains of dosed males were similar to those of the controls . There were no clinical signs of toxicity. There were no significant differences in organ weights or urinalysis parameters between dosed and control males. No microscopic effects attributable to 1,1,1-TriC-2,2,2-TFE administration were present in either the kidney or the liver at either dose level. PCNA staining was not performed due to the absence of a detectable treatment effect in routine sections.

1,1,1-Trichloro-2,2,2-trifluoroethane's production and use as a solvent(1) and as an intermediate in the production of 2,3-dichloro-5-trifluoromethylpyridine(2) may result in its release to the environment through various waste streams(SRC). The compound is often present in low levels in CFC113(2). Fully halogenated chlorofluorocarbons (CFCs), such as 1,1,1-trichloro-2,2,2-trifluoroethane, were scheduled for production phase-out in 1987 by the Montreal Protocol(2). Although originally scheduled for 50% production phase-out by the year 2000 in developed countries, the worsening ozone depletion has forced acceleration of the CFC phase-out(2,3).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 200(SRC), determined from a structure estimation method(2), indicates that 1,1,1-trichloro-2,2,2-trifluoroethane is expected to have moderate mobility in soil(SRC). Volatilization of 1,1,1-trichloro-2,2,2-trifluoroethane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.27 atm-cu m/mole(SRC), using a fragment constant estimation method(3). 1,1,1-Trichloro-2,2,2-trifluoroethane is expected to volatilize from dry soil surfaces(SRC) based upon an measured vapor pressure of 360 mm Hg at 25 °C(4). Biodegradation data in soil were not available(SRC, 2012).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 200(SRC), determined from a structure estimation method(2), indicates that 1,1,1-trichloro-2,2,2-trifluoroethane is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.27 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hours and 5 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 51(SRC), from an estimated log Kow of 3.09(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Biodegradation data in water were not available(SRC, 2012).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,1,1-trichloro-2,2,2-trifluoroethane, which has a measured vapor pressure of 360 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. 1,1,1-Trichloro-2,2,2-trifluoroethane is essentially inert to reaction with photochemically generated radicals and ozone molecules(3,4). 1,1,1-Trichloro-2,2,2-trifluoroethane does not contain chromophores that absorb at wavelengths >290 nm(5) and, therefore, is not expected to undergo direct photolysis by sunlight in the troposphere(SRC). 1,1,1-Trichloro-2,2,2-trifluoroethane will gradually diffuse into the stratosphere above the ozone layer where it will slowly degrade due to direct photolysis from UV-C radiation and contribute to the catalytic removal of stratospheric ozone(6).

Vapor-phase 1,1,1-trichloro-2,2,2-trifluoroethane is extremely stable and will not undergo direct photolysis in the troposphere(1,3); this compound does not react with photochemically produced hydroxyl radicals, ozone molecules, or nitrate radicals in the troposphere(2). 1,1,1-Trichloro-2,2,2-trifluoroethane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to undergo direct photolysis by sunlight in the troposphere(SRC). 1,1,1-Trichloro-2,2,2-trifluoroethane will however gradually diffuse into the stratosphere above the ozone layer where it does slowly degrade due to direct photolysis from UV-C radiation and contribute to the catalytic removal of stratospheric ozone(SRC). Once in the upper stratosphere, it is dissociated through photolysis, reaction with hydroxyl radical and excited atomic oxygen resulting in the release of chlorine. These chlorine atoms then become part of a catalytic process that contributes to the destruction of the ozone layer(3,5,6). By analogy to other Freon compounds, 1,1,1-trichloro-2,2,2-trifluoroethane is predicted to have a stratospheric lifetime on the order of several decades(7). Chemical hydrolysis of 1,1,1-trichloro-2,2,2-trifluoroethane is not an important environmental fate process(7).

An estimated BCF of 51 was calculated in fish for 1,1,1-trichloro-2,2,2-trifluoroethane(SRC), using an estimated log Kow of 3.09(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1,1,1-trichloro-2,2,2-trifluoroethane can be estimated to be 200(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1,1,1-trichloro-2,2,2-trifluoroethane is expected to have moderate mobility in soil.

The Henry's Law constant for 1,1,1-trichloro-2,2,2-trifluoroethane is estimated as 0.27 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 1,1,1-trichloro-2,2,2-trifluoroethane is expected to volatilize rapidly from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 4 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 5 days(SRC). 1,1,1-trichloro-2,2,2-trifluoroethane's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 1,1,1-Trichloro-2,2,2-trifluoroethane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 360 mm Hg(3).

According to the 2006 TSCA Inventory Update Reporting data, the number of persons reasonably likely to be exposed in the industrial manufacturing, processing, and use of 1,1,1-trichloro-2,2,2-trifluoroethane is 100-999; the data may be greatly underestimated(1).|Occupational exposure to 1,1,1-trichloro-2,2,2-trifluoroethane may occur through inhalation and dermal contact with this compound at workplaces where 1,1,1-trichloro-2,2,2-trifluoroethane is produced or used. Monitoring data indicate that the general population may be exposed to 1,1,1-trichloro-2,2,2-trifluoroethane via inhalation of ambient air. (SRC)

1,1,1-Trichloro-2,2,2-trifluoroethane was detected in the expired air of 6 out of 10 air samples taken from 8 smoking and non-smoking male volunteers from Texas, at expiration rates from 2.6-63.0 and 11.0-580 ug/kg, respectively(1).

Regardless of the route of entry, chlorofluorocarbons appear to be eliminated almost exclusively through the respiratory tract. Little, if any, chlorofluorocarbon or metabolite has ever been reported in urine or feces. /Chlorofluorocarbons/

Chlorofluoroalkanes (and also the alternative HCFCs and HFCs) produced on an industrial scale are subject to stringent standards. Impurities must not exceed the following limits (vol %): acids, 0; moisture, <0.001; higher-boiling fractions, <0.05; and other gases, 2. /Chlorofluoroalkanes/

Victims of freon inhalation require management for hypoxic, CNS anesthetic, & cardiac symptoms. Patients must be removed from the exposure environment, & high flow supplemental oxygen should be utilized. The respiratory system should be evaluated for injury, aspiration, or pulmonary edema & treated appropriately. CNS findings should be treated supportively. A calm environment with no physical exertion is imperative to avoid increasing endogenous adrenegic levels. Exogenous adrenergic drugs must not be used to avoid inducing sensitized myocardial dysrhythmias. Atropine is ineffective in treating bradyarrhythmias. For ventricular dysrhythmias, diphenylhydantoin & countershock may be effective. Cryogenic dermal injuries should be treated by water bath rewarming at 40-42 °C until vasodilatory flush has returned. Elevation of the limb & standard frostbite management with late surgical debridement should be utilized. Ocular exposure requires irrigation & slit lamp evaluation for injury. /Freons/|Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Chlorinated fluorocarbons (CFCs) and related compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations as needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Minimize physical activity and provide a quiet atmosphere. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. Rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . Treat frostbite with rapid rewarming techniques ... . /Chlorinated fluorocarbons (CFCs) and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia,administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Chlorinated fluorocarbons (CFCs) and related compounds/|For more Antidote and Emergency Treatment (Complete) data for 1,1,1-TRICHLORO-2,2,2-TRIFLUOROETHANE (7 total), please visit the HSDB record page.

/SIGNS AND SYMPTOMS/ Aerosol sprays containing fluorocarbon propellants are another source of solvent intoxication. Prolonged exposure or daily use may result in damage to several organ systems. Clinical problems include cardiac arrhythmias, bone marrow depression, cerebral degeneration, and damage to liver, kidney, & peripheral nerves. Death occasionally has been attributed to inhalant abuse, probably via the mechanism of cardiac arrhythmias, especially accompanying exercise or upper airway obstruction. /Fluorocarbon propellants/|/CASE REPORTS/ During the course of dockside ship maintenance, a compartment was partially flooded with Trichlorotrifluoroethane gas. One sailor entered the compartment, collapsed, and was then rescued by two other men. All three victims then climbed a 11-m (36-ft) ladder and collapsed. They all experienced a rapid development of cardiac arrest. /Investigators/ report on the pathologic, toxicologic, and pathophysiologic aspects of the incident.|/CASE REPORTS/ A case is presented of a 16-year-old male who died as a result of exposure to Trichlorotrifluoroethane while working in an open pit. Chromatographic results and tissue concentrations are presented.|/OTHER TOXICITY INFORMATION/ The available toxicological data on the fully halogenated chlorofluorocarbons reviewed in this monograph show a low acute and chronic toxicity and indicate no mutagenic or carcinogenic potential. The human health risks are mainly confined to occasional high exposures that may occur during the handling of these substances. In contrast, indirect effects from the accumulation of these substances in the stratosphere may lead to substantial effects on human health, mainly due to the depletion of stratospheric ozone resulting in an increase in effects from UV-B radiation. The projected increase in the incidence of non-melanoma skin cancers, a possible increase in melanoma skin cancers, and immunotoxic and ocular effects suggest that immediate action is required to reduce further stratospheric ozone depletion. /Halogenated chlorofluorocarbons/|/OTHER TOXICITY INFORMATION/ The toxicity of Chlorofluorocarbons (CFCs) had been considered to be low; it is absorbed via the lungs and undergoes little subsequent biotransformation. In the United States when sudden unexplained deaths of aerosol "sniffers" were reported they were considered to be possibly due to cardiac arrhythmias induced by the CFC propellants. /CFCs/

1,1,1-trichloro-2,2,2-trifluoroethane

All other basic organic chemical manufacturing|Ethane, 1,1,1-trichloro-2,2,2-trifluoro-: ACTIVE|SRP: The EPA has organized groups of chemicals into two classes according to their ozone-depletion potential. Class I controlled substances are those with an ozone-depletion potential of 0.2 or higher. Class II controlled substances are those with an ozone-potential of less than 0.2. Class II controlled substances are all hydrochlorofluorocarbons (HCFCs).|In the United States, "Class I" substances were subject to the first round of phaseout targets. Class I substances have an ozone depletion potential (ODP) of 0.2 or higher, and include halons, chlorofluorocarbons (CFCs), methyl chloroform, carbon tetrachloride, and methyl bromide. Section 604 of the Clean Air Act sets the phaseout targets for Class I substances. The ban on production and import of halons took effect on January 1, 1994. The ban on production and import of other Class I ODS /ozone-depleting substance/ - excluding methyl bromide - took effect on January 1, 1996.|Class I Controlled Substance: C2F3Cl3 - Trichlorotrifluoroethane (CFC-113) /and all isomers/: Ozone-depletion potential: 0.8.|Not offered as a commercial product ... often present in low levels in CFC113 ... being phased out since it is an ozone-depleting substance ... covered under the Montreal Protocol|For more General Manufacturing Information (Complete) data for 1,1,1-TRICHLORO-2,2,2-TRIFLUOROETHANE (7 total), please visit the HSDB record page.

NIOSH Method: 1018. Analyte: 1,2-dichlorotetrafluoroethane. Matrix: Air. Procedure: Gas chromatography, flame ionization detector. For 1,2-dichlorotetrafluoroethane this method has an estimated detection limit of 0.03 mg/sample. The precision/RSD is 0.038 at 10 to 40 mg/sample and the recovery is not given. Applicability: The working range is 240 to 2100 ppm (1670 to 15,000 mg/cu m) 1,2-dichlorotetrafluoroethane for a 3 liter air sample. Interferences: Methanol and acetone may interfere if present at high concentrations. /1,2-dichlorotetrafluoroethane/|Chemical analysis was conducted by gas chromatography and mass spectrometry. The chromatograph was a dual column instrument with both flame ionization and electron capture detector. The carrier gas (helium) at a flow rate of 50 ml/min. The analyzed hydrocarbon content for the six bottles of supply gas ranged from 0.06 to 0.5 ppm. /1,1,1-Trifluorotrichloroethane/|NIOSH Method 1020. Analyte: 1,1,2-trichloro-1,2,2-trifluoroethane. Matrix: Air. Procedure: Gas chromatography, flame ionization detector. For 1,1.2-trichloro-1,2,2-trifluoroethane this method has an estimated detection limit of 0.005 mg/sample. The precision/RSD 0.02 at 5.6 to 23 mg/sample and the recovery is not given. Applicability: The working range is 10 to 17000 mg/cu m (1.3 to 2300 ppm) for a 1.5 liter air sample. Interferences: None identified. /1,1,2-Trichloro-1,2,2-trifluoroethane/