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1,3,3-Trimethyl-2-methyleneindoline

1,3,3-Trimethyl-2-methyleneindoline structure

CAS No:
118-12-7
Formula:
C12H15N
Chemical Name:
1,3,3-Trimethyl-2-methyleneindoline
Synonyms:
1H-Indole,2,3-dihydro-1,3,3-trimethyl-2-methylene-;Indoline,1,3,3-trimethyl-2-methylene-;2,3-Dihydro-1,3,3-trimethyl-2-methylene-1H-indole;Fischer base;Fischer's base;1,3,3-Trimethyl-2-methyleneindoline;1,3,3-Trimethyl-2-methylene-2,3-dihydroindole;2-Methylene-1,3,3-trimethylindoline;1,2-Dihydro-1,3,3-trimethyl-2-methyleneindole;2,3-Dihydro-1,3,3-trimethyl-2-methyleneindole;1,3-Dihydro-1,3,3-trimethyl-2-methyleneindoline;Fischer's methylene base;NSC 66176;1,3,3-Trimethyl-2-methylene indolenine;1,3,3-Trimethyl-2-methylidene-2,3-dihydro-1H-indole;1,3,3-Trimethyl-2-methylideneindole
Categories:
Analytical Chemistry > Analysis Reagents

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Description

clear red liquid

Liquid

1,3,3-Trimethyl-2-methyleneindoline Basic Attributes

Molecular Weight：

173.25

Exact Mass：

173.25

BRN：

131162

EC Number：

204-235-1

NSC Number：

66176

DSSTox ID：

DTXSID8051596

HScode：

29339990

Characteristics

PSA：

3.2

XLogP3：

2.99270

Appearance：

red liquid

Density：

0.979 g/mL at 25 °C(lit.)

Melting Point：

-8 °C

Boiling Point：

80 °C @ Press: 0.01 Torr

Flash Point：

215 °F

Refractive Index：

n 20/D 1.577(lit.)

Water Solubility：

negligible

Storage Conditions：

Store below +30°C.

Vapor Pressure：

0.0249mmHg at 25°C

Safety Information

Packing level：

III

Hazard category：

Transport codes：

UN 3082 9/PG 3

wgk germany：

hazard class code：

22-38-50/53

safety instructions：

28-60-61-57-37

RTECS Number：

NM1926500

Marks：

Xn,N

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P273

Hazard Statements：

H302-H315-H400

GHS Classification：

|Warning|H302 (97.24%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P273, P280, P301+P312, P302+P352, P321, P330, P332+P313, P362, P391, and P501|Aggregated GHS information provided by 146 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

1,3,3-Trimethyl-2-methyleneindoline Use and Manufacturing

Methods of Manufacturing

It is prepared by condensation of phenylhydrazine and methyl ethyl ketone, ring-closure reaction, methylation with methyl toluenesulfonate, and neutralization with ammonia. Put water, phenylhydrazine, and sulfuric acid into the reaction pot, heat to 80°C, add methyl ethyl ketone dropwise, and control the feeding temperature at 80-90°C. After the addition, continue to react at 90-100°C for 1.5h. Cool to 70°C, add xylene, let stand to separate the lower layer of water, and wash the xylene layer with water again. Add methyl p-toluenesulfonate, heat, react at 155-160°C for 3 hours, and then react at 160-165°C for 3 hours, dilute the reaction material in water, and add 20% ammonia water dropwise at 70-90°C until the pH is greater than 8. After standing for stratification, the upper oil layer is subjected to vacuum distillation, and the fraction above 80°C (1.33-2.67kPa) is collected as the finished product. The yield is about 70%.

Uses

This product can be used as a dye intermediate for the manufacture of cationic golden X-GL, cationic pink FG, cationic brilliant red 5-GN, cationic red 6B, cationic red 3GL, etc.

Intermediates

Manufacturing Info：

All other basic organic chemical manufacturing|1H-Indole, 2,3-dihydro-1,3,3-trimethyl-2-methylene-: ACTIVE

Computed Properties

Molecular Weight:173.25
XLogP3:3.4
Hydrogen Bond Acceptor Count:1
Exact Mass:173.120449483
Monoisotopic Mass:173.120449483
Topological Polar Surface Area:3.2
Heavy Atom Count:13
Complexity:229
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Hydrazine, phenyl-

Sodium carbonate

Aniline

Sodium pyrosulfite

Dimethyl sulfate

Recommended Suppliers of 1,3,3-Trimethyl-2-methyleneindoline

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

1,3,3-Trimethyl-2-methyleneindoline

CAS No.: 118-12-7

Content: 99.00%

Inquiry
Hangzhou Chungyo Chemicals Co., Ltd. Contact Supplier

CN
3 YRS

Business licensed Certified factory

Manufactory Supplier of Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals

1,3,3-Trimethyl-2-methyleneindoline

CAS No.: 118-12-7

Grade: Industrial Grade

Content: 98%

Inquiry

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Guide of 1,3,3-Trimethyl-2-methyleneindoline

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Material
Recommended Suppliers
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1,3,3-Trimethyl-2-methyleneindoline

SDS

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