3-Bromo-5-ethoxy-4-hydroxybenzaldehyde

General procedure: a mixture of substrate 1a(1 mmol), cobalt salt (nThe 3-ethoxy-4-hydroxybenzaldehyde (6.64g, 40 . 0mmol) dissolved in acetic acid (80 ml) in, is fully dissolved. Then the liquid bromine (2.46 ml) is added dropwise to the reaction solution, after the end of dropping, the reaction at room temperature 3 hours, turbid. TLC monitoring after the reaction is ended, filtering to get the solid, the solid will be 50percent ethanol aqueous solution to re-crystallization, to obtain a target compound 1.1 is 7.8g, yield 80percent.Example 3 General procedure: Thiosemicarbazide (1 mmol) was dissolved in 20 ml of ethanol under heating and appropriate aldehyde (1 mmol) was added. The resulting mixture was heated to solid formation. Solid products were filtered, washed with ethanol (2 × 5 ml), and dried. The compounds have been already patented by us [13].

Molecular Weight:245.07
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:243.97351
Monoisotopic Mass:243.97351
Topological Polar Surface Area:46.5
Heavy Atom Count:13
Complexity:174
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes