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Diphenidol hydrochloride

Diphenidol hydrochloride structure

CAS No:
3254-89-5
Formula:
C21H27NO.ClH
Chemical Name:
Diphenidol hydrochloride
Synonyms:
1-Piperidinebutanol,α,α-diphenyl-,hydrochloride (1:1);1-Piperidinebutanol,α,α-diphenyl-,hydrochloride;Diphenidol hydrochloride;Ansmin;Cefadol;Vontrol;Difenidolin;Tenesdol;SKF 478A;Wansar;Satanolon;Mecalmin;Pineroro;Celmidol;Maniol;Difenidol hydrochloride;1,1-Diphenyl-4-(piperidin-1-yl)butan-1-ol hydrochloride
Categories:
Active Pharmaceutical Ingredients > Digestive System Drugs

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Description

Diphenidol hydrochloride is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent.

Difenidol hydrochloride is a diarylmethane.

Diphenidol hydrochloride Basic Attributes

Molecular Weight：

309.45

Exact Mass：

345.186

EC Number：

221-850-0

UNII：

DG355XWQ4T

NSC Number：

23012

DSSTox ID：

DTXSID10186248

HScode：

2933399090

Characteristics

PSA：

23.5

XLogP3：

4.12650

Appearance：

crystals, soluble in methanol, water

Melting Point：

212-214 °C

Boiling Point：

473.3°C at 760 mmHg

Flash Point：

233.5ºC

Toxicity：

Oral-rat LD50: 515 mg/kg; Oral-Mouse LD50: 400 mg/kg

Flammability characteristics：

Thermal decomposition to emit toxic nitrogen oxide fumes

Safety Information

wgk germany：

hazard class code：

20/21/22

safety instructions：

RTECS Number：

TM4970500

Marks：

Storage features：

The warehouse is low-temperature, ventilated and dry; stored separately from food materials

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 91 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

MeSH Entry Terms：

Cefadol

Diphenidol hydrochloride Use and Manufacturing

Uses

Diphenidol is an muscarinic antagonist is an antivertigo agent. Diphenidol displays heart arrhythmia inhibition and parasympatholytic activity.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:345.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:345.1859422
Monoisotopic Mass:345.1859422
Topological Polar Surface Area:23.5
Heavy Atom Count:24
Complexity:307
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Morpholine

Ethyl bromide

Drug Function and Efficacy

It can improve the blood supply to the vertebral artery, regulate the function of the vestibular system, inhibit the vomiting center, and have anti-vertigo and antiemetic effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Difenidol Hydrochloride Tablets
Ingredients	Each tablet of this product contains 25 mg of difenidol hydrochloride, and the excipients are starch, sucrose, magnesium stearate, microcrystalline cellulose, and hydroxypropyl cellulose.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	25mg
Manufacturer	Beijing Haiwang Zhongxin Pharmaceutical Co., Ltd.

Difenidol Hydrochloride Tablets
Ingredients	Diphenidol Hydrochloride
Indication	If you are taking other medicines, please consult your physician or pharmacist before using this product.
Specifications	25mg
Manufacturer	Shanxi Zhendong Anxin Biopharmaceutical Co., Ltd.

Diphenidol Hydrochloride

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Registered Holders

みどり化学株式会社

Japan
Active
Hunan Qianjin Xiangjiang Pharmaceutical Co., Ltd.

China
Active
Zhejiang Ruixin Pharmaceutical Co., Ltd.

China
Active

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