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Methanesulfonamide

Methanesulfonamide structure

CAS No:
3144-09-0
Formula:
CH5NO2S
Chemical Name:
Methanesulfonamide
Synonyms:
Methanesulfonamide;Methylsulfonamide;Methanesulphonamide;Methanesulfonic amide;Mesylamide;NSC 191039;NSC 271
Categories:
Pharmaceutical Intermediates > Respiratory Tract

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Description

White to yellow crystals, powder or flakes

Methanesulfonamide Basic Attributes

Molecular Weight：

95.12090

Exact Mass：

95.12

EC Number：

221-553-6

UNII：

98YB2P6NHR

NSC Number：

271

DSSTox ID：

DTXSID3062865

HScode：

29350090

Characteristics

PSA：

68.54000

XLogP3：

-1.1

Appearance：

off-white flakes

Density：

1.363 g/cm1.363 g/cm3

Melting Point：

88 °C

Boiling Point：

208.2ºC at 760 mmHg

Flash Point：

79.7ºC

Refractive Index：

1.46

Storage Conditions：

Store in a cool, dry place. Store in a tightly closed container.

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S24/25

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (98.08%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 52 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

CH3SO2NH2

Methanesulfonamide Use and Manufacturing

Uses

Methanesulfonamide is used in biological studies to predict binding affinity and binding mode of protein ligand complexes.

Manufacturing Info：

Methanesulfonamide: ACTIVE

Computed Properties

Molecular Weight:95.12
XLogP3:-1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:95.00409958
Monoisotopic Mass:95.00409958
Topological Polar Surface Area:68.5
Heavy Atom Count:5
Complexity:95.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Cyclohexane

1-Methyl-4-nitrosobenzene

Ethanol

Acetonitrile

Dichloromethane

Downstream Products

p-Toluenesulfonamide

Drug Function and Efficacy

This product is a carbonic anhydrase inhibitor, which can inhibit the production of aqueous humor and reduce intraocular pressure. The ease of aqueous humor outflow does not change. Acetazolamide can inhibit the activity of carbonic anhydrase in the ciliary epithelium, thereby reducing the production of aqueous humor (50% to 60%) and lowering intraocular pressure.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Acetazolamide Tablets
Ingredients	Methanesulfonamide
Indication	(1) When used in combination with adrenocorticotropic hormone, glucocorticoids, and especially mineralocorticoids, it can cause severe hypokalemia. When using these drugs together, it is important to monitor serum potassium concentration and cardiac function. It should also be estimated that long-term simultaneous use may increase the risk of hypocalcemia and cause osteoporosis, because these drugs can increase calcium excretion. (2) When used in combination with amphetamines, anticholinergics, and especially atropine and quinidine, the excretion of this product is reduced due to the formation of alkaline urine, which may aggravate or prolong adverse reactions. (3) When used in combination with antidiabetic drugs (such as insulin), it can reduce hypoglycemia reactions, because this product can cause hyperglycemia and glycosuria, so the dose should be adjusted. (4) When used in combination with phenobarbital, carbamazepine, or phenytoin, it may cause an increase in the incidence of osteomalacia. (5) When digitalis glycosides are used in combination with this product, the toxicity of digitalis may be increased and hypokalemia may occur. (6) When used in combination with mannitol or urea, it can increase urine volume while enhancing the effect of lowering intraocular pressure.
Specifications	0.25 g
Manufacturer	Suzhou Homesun Pharmaceutical Co., Ltd.

Acetazolamide Tablets
Ingredients	Methanesulfonamide
Indication	(1) When used in combination with adrenocorticotropic hormone, glucocorticoids, and especially mineralocorticoids, it can cause severe hypokalemia. When using these drugs together, it is important to monitor serum potassium concentration and cardiac function. It should also be estimated that long-term simultaneous use may increase the risk of hypocalcemia and cause osteoporosis, because these drugs can increase calcium excretion. (2) When used in combination with amphetamines, anticholinergics, and especially atropine and quinidine, the excretion of this product is reduced due to the formation of alkaline urine, which may aggravate or prolong adverse reactions. (3) When used in combination with antidiabetic drugs (such as insulin), it can reduce hypoglycemia reactions, because this product can cause hyperglycemia and glycosuria, so the dose should be adjusted. (4) When used in combination with phenobarbital, carbamazepine, or phenytoin, it may cause an increase in the incidence of osteomalacia. (5) When digitalis glycosides are used in combination with this product, the toxicity of digitalis may be increased and hypokalemia may occur. (6) When used in combination with mannitol or urea, it can increase urine volume while enhancing the effect of lowering intraocular pressure.
Specifications	0.25 g
Manufacturer	Suzhou Homesun Pharmaceutical Co., Ltd.

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