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Acepromazine maleate

Acepromazine maleate structure

CAS No:
3598-37-6
Formula:
C19H22N2OS.C4H4O4
Chemical Name:
Acepromazine maleate
Synonyms:
Ethanone,1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-,(2Z)-2-butenedioate (1:1);Ketone,10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl,maleate (1:1);Ethanone,1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-,(Z)-2-butenedioate (1:1);Ketone,10-[3-(dimethylamino)propyl]phenothiazin-2-yl methyl,maleate;Maleic acid,compd. with 10-(3-dimethylaminopropyl)phenothiazin-2-yl methyl ketone;Acepromazine maleate;Acepromazine monomaleate;Anatran;Notenzil;Plegicil;Soprontin;Acetylpromazine maleate;Atravet;Sedalin;Calmivet;Notensil;NSC 264522;Acetopromazine maleate salt;Calmo Neosan;Acepran;2664-15-5
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Yellow Crystalline Solid

Acepromazine Maleate is the maleate salt of acepromazine, a phenothiazine derivative with depressant effect on the central nervous system. Acepromazine acts as a dopamine receptor antagonist in the CNS, thereby causing sedation, muscular relaxation and a reduction in spontaneous activity. Its fast-acting neuroleptic effect with low toxicity is of particular value in veterinary medicine.|A phenothiazine that is used in the treatment of PSYCHOSES.

Acepromazine maleate Basic Attributes

Molecular Weight：

442.53

Exact Mass：

442.15600

EC Number：

222-748-9

UNII：

37862HP2OM

NSC Number：

760058

DSSTox ID：

DTXSID6047783

NCI Thesaurus Code：

C76652

HScode：

2934300000

Characteristics

PSA：

123

XLogP3：

4.22040

Appearance：

yellow

Density：

1.155g/cm3

Melting Point：

135-136 °C

Boiling Point：

230°C

Flash Point：

254.4ºC

Water Solubility：

H2O: >10mg/mL

Storage Conditions：

-20°C Freezer

Toxicity：

Oral-rat LD50:400mg/kg;Oral-Mouse LD50: 270 mg/kg

Flammability characteristics：

Combustible; Decomposes by heating and releases highly toxic nitrogen oxides and sulfur oxide fumes

Safety Information

Transport codes：

UN 3077

wgk germany：

hazard class code：

22-50/53-20/21/22-43-36/37/38-23/24/25

safety instructions：

60-61-36/37/39-26-22-45

RTECS Number：

2664-15-5

Marks：

Xn,N,T

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P280

Hazard Statements：

H302 + H312 + H332

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 42 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)

MeSH Entry Terms：

Acepromazine

Acepromazine maleate Use and Manufacturing

Uses

vitamin D2 analog, blood calcium regulator, therapeutc for chronic hypocalcemia

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:442.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:442.15624311
Monoisotopic Mass:442.15624311
Topological Polar Surface Area:123
Heavy Atom Count:31
Complexity:533
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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