4-(2-Chloroethyl)morpholine hydrochloride
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4-(2-Chloroethyl)morpholine hydrochloride
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CAS No:
3647-69-6
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Formula:
C6H12ClNO.ClH
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Chemical Name:
4-(2-Chloroethyl)morpholine hydrochloride
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Synonyms:
Morpholine,4-(2-chloroethyl)-,hydrochloride (1:1);Morpholine,4-(2-chloroethyl)-,hydrochloride;N-(β-Chloroethyl)morpholine hydrochloride;2-Morpholinoethyl chloride hydrochloride;N-(2-Chloroethyl)morpholine hydrochloride;2-(4-Morpholinyl)ethyl chloride hydrochloride;4-(2-Chloroethyl)morpholine hydrochloride;β-Morpholinoethyl chloride hydrochloride;1-Chloro-2-morpholinoethane hydrochloride;Morpholinoethyl chloride hydrochloride;4-(2-Chloroethyl)morpholinium chloride;4-(2-Chloroethyl)morpholine monohydrochloride;1-(Morpholin-4-yl)-2-chloroethane hydrochloride;1-Chloro-2-(morpholin-4-yl)ethane monohydrochloride
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CAS No:
4-(2-Chloroethyl)morpholine hydrochloride Basic Attributes
186.08
185.037415
222-881-2
46824|10003
DTXSID0052043
2934999090
Characteristics
12.5
1.088g/cm3
182-182.5 °C
76.4ºC
soluble
LD50 orally in Rabbit: 96 mg/kg LD50 dermal Rat 1502 mg/kg
Safety Information
III
UN 2923 8/PG 3
2
R21;R25;R34;R43;R52/53
S26-S36/37/39-S45-S61
QE0260000
T:Toxic;
P280-P301 + P310-P305 + P351 + P338-P310
H301-H312-H314-H317
|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P261, P264, P270, P272, P273, P280, P281, P301+P310, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P313, P310, P312, P321, P322, P330, P333+P313, P363, P405, and P501|Aggregated GHS information provided by 97 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4-(2-Chloroethyl)morpholine hydrochloride Use and Manufacturing
The 5.0ml morpholine (57.5 mmol) and 4.6 ml of 2-chloroethanol (69.0 mmol) was added to 40ml of toluene was heated at reflux for 2 hours. The reaction solution was cooled to room temperature and 8.4 ml (114 mmol) of thionyl chloride was added dropwise to the ice bath. After 20 min, the ice bath was removed and stirred at room temperature for 6 hours. The toluene and thionyl chloride were distilled off under reduced pressure and the residual solid was recrystallized from ethanol to give ethyl chloro morpholine hydrochloride Salt 7.9g.
4-(2-Chloroethyl)morpholine hydrochloride (MOC) is used as intermediate for the synthesis of pharmaceuticals (e.g. floredil, morinamide, nimorazole and pholcodine). Product Data Sheet 4-(2-Chloroethyl)morpholine is used in the preparation of potential DNA cross-linking antitumor agents as well as synthetic opiate analogues. 4-(2-Chloroethyl)morpholine may possess sickle-cell hemogl obin aggregation inhibiting-activity.
Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1): ACTIVE
Computed Properties
Molecular Weight:186.08
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:185.0374194
Monoisotopic Mass:185.0374194
Topological Polar Surface Area:12.5
Heavy Atom Count:10
Complexity:73.5
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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