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Lidoflazine

Lidoflazine structure

CAS No:
3416-26-0
Formula:
C30H35F2N3O
Chemical Name:
Lidoflazine
Synonyms:
1-Piperazineacetamide,4-[4,4-bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-;1-Piperazineaceto-2′,6′-xylidide,4-[4,4-bis(p-fluorophenyl)butyl]-;4-[4,4-Bis(4-fluorophenyl)butyl]-N-(2,6-dimethylphenyl)-1-piperazineacetamide;McN-JR 7904;R 7904;Clinium;1-[4,4-Di(4-fluorophenyl)butyl]-4-[(2,6-dimethylanilinocarbonyl)methyl]piperazine;Klinium;Lidoflazine;1-[4,4-Bis(4-fluorophenyl)butyl]-4-(2,6-dimethylphenylcarbamoylmethyl)piperazine;4-[4,4-Bis(p-fluorophenyl)butyl]-1-piperazineaceto-2′,6′-xylidide;Ordiflazine;Corflazine;1-[4,4-Bis(fluorophenyl)butyl]-4-(2,6-dimethylanilinocarbonylmethyl)piperazine;Lidoflazinum;Lidoflazin;McN-JR 7094;Angex;2-(4-(4,4-Bis(4-fluorophenyl)butyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide;31032-48-1
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Lidoflazine is a high affinity blocker of the HERG (human ether-a-go-go-related gene) K+ channel. Lidoflazine is an antianginal calcium channel blocker that carries a significant risk of QT interval prolongation and ventricular arrhythmia[1].

2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide is a diarylmethane.|Coronary vasodilator with some antiarrhythmic action.

Lidoflazine Basic Attributes

Molecular Weight：

491.622

Exact Mass：

491.62

EC Number：

222-312-8

UNII：

J4ZHN3HBTE

DSSTox ID：

DTXSID6045377

ATC Code：

C - Cardiovascular system

Characteristics

PSA：

35.6

XLogP3：

5.69880

Appearance：

white

Density：

1.161g/cm3

Melting Point：

159-161 °C

Boiling Point：

632.6ºC at 760mmHg

Flash Point：

336.4ºC

Refractive Index：

1.581

Water Solubility：

DMSO: ≥10mg/mL

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

TK7910000

Marks：

Drug Information

MeSH：

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

Clinium

Lidoflazine Use and Manufacturing

Coronary vasodilatator;Ca++ channel activator

Computed Properties

Molecular Weight:491.6
XLogP3:6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:491.27481907
Monoisotopic Mass:491.27481907
Topological Polar Surface Area:35.6
Heavy Atom Count:36
Complexity:623
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes