Isopropyl acetate

102.13200

102.13

203-561-1

1Y67AFK870

0907

9295

1220

DTXSID2025478

Water-white liquid|Colorless liquid.

2915390090

26.30000

0.95790

Isopropyl acetate appears as a clear colorless liquid. Flash point 40°F. Vapors are heavier than air. Contact with the material may irritate skin, eyes or mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Used as a solvent.

0.8718 g/cm³ @ Temp: 20 °C

-73.4 °C

88.6 °C @ Press: 760 Torr

11ºC

1.377

H2O: 2.90 g/100 mL

Flammables area

47 mm Hg ( 20 °C)

3.5 (vs air)

Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.

Explosive limits , vol% in air: 1.8-7.8

Aromatic

ON DILUTION A SWEET APPLE-LIKE FLAVOR

3.40e-12 cm3/molecule*sec

2.78e-04 atm-m3/mole|Henry's Law constant = 2.78X10-4 atm cu-m/mol at 25 °C

Ratio of Specific Heats of Vapor (Gas): (est) 1.074|Hydroxyl radical rate constant = 3.40X10-12 cu-cm/molc sec @ 25 °C

Highly flammable. Less dense than water and slightly soluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Highly Flammable

ISOPROPYL ACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. This compound can react vigorously with nitrates, strong oxidizers, strong alkalis and strong acids. This chemical may also attack some forms of rubber, plastics and coatings. (NTP, 1992).

860 °F (USCG, 1999)|460 °C (860 °F)|425 °C

-9420 Btu/lb= -5230 cal/g= -219X10+3 J/kg

9.95 eV

Lower: 1.8% by vol @ 38 °C; Upper: 8% by vol|Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.

The vapour is heavier than air and may travel along the ground; distant ignition possible.

150 Btu/lb= 81 cal/g= 3.4X10+5 J/kg

Critical Temp: 265 °C; Critical Pressure: 36 atm

II

3

UN 1220

1

R11; R36/37/38

S16-S26-S36

AI4930000

F; Xi

Fireproof. Separated from oxidants, strong acids and strong bases. Dry. Keep in a well-ventilated room. Store in an area without drain or sewer access.

Stable. Flammable - note low flash point. Incompatible with strong oxidizing agents, strong acids, nitrates, alkali metals. May attack some plastics and rubber.

P210-P305 + P351 + P338-P370 + P378-P403 + P235

H225-H319-H336

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|1. By absorbing it in vermiculite, dry sand, earth or a similar material and disposing in a secured sanitary landfill. 2. By atomizing in a suitable combustion chamber.|Isopropyl acetate is a waste chemical stream constituent which may be subjected to ultimate disposal by controlled incineration.|The following wastewater treatment technologies have been investigated for isopropyl acetate: Concentration process: Activated carbon.

... CAN REACT VIGOROUSLY WITH OXIDIZING MATERIALS.|Nitrates; strong oxidizers, alkalis & acids.

Isopropyl acetate is an indirect food additive for use only as a component of adhesives.|Isopropyl acetate is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.

Inoue T et al; A nationwide survey on organic solvent components in various solvent products: 1. Homogeneous products such as thinners, degreasers and reactants. Ind Health; 21 (3): 175-184 (1983). Organic solvent products used in factories were collected nationwide in Japan and analyzed by gas chromatography.

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)|Highly flammable. Vapour/air mixtures are explosive.|Flammable - 3rd degree

|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P312, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 3144 companies from 38 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P312, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P310, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P309+P311, P312, P314, P321, P331, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 129 [Flammable Liquids (Water-Miscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|Organic vapor canister or air-supplied mask; chem goggles or face splash shield|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|For more Personal Protective Equipment (PPE) (Complete) data for ISOPROPYL ACETATE (8 total), please visit the HSDB record page.|(See protection codes)

KEEP AWAY FROM HEAT & OPEN FLAME ... Dangerous fire hazard when exposed to heat, flame, or oxidizers. Moderatedly explosive when exposed to heat or flame.|Floats and mixes slowly with water. Flammable, irritating vapor is produced.

LOWER 1.8%; UPPER 7.8%.|Vapor may explode if ignited in an enclosed area.|Explosive limits , vol% in air: 1.8-7.8

Extinguish with dry chem, /alcohol/ foam, or carbon dioxide. Water may be ineffective. Cool exposed containers with water.|Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities. Apply water from as far a distance as possible.

Flashback along vapor trail may occur.

1. Remove all ignition sources. 2. Ventilate area of spill or leak. 3. For small quantities, absorb on paper towels. Evaporate in a safe place (such as a fume hood). Allow sufficient time for evaporating vapors to completely clear the hood ductwork. Burn the paper in a suitable location away from combustible materials. Large quantities can be collected and atomized in a suitable combustion chamber.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|... PROCESSES ... SHOULD BE EQUIPPED WITH EXHAUST VENTILATION. APPROPRIATE SAFETY MEASURES ARE REQUIRED FOR WORK IN CONFINED SPACES ... . /ESTERS/|The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet should be immediately removed due to its flammability hazard.

/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Health: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Public Safety: CALL Emergency Response Telephone Number on Shipping Paper first. If Shipping Paper not available or no answer, refer to appropriate telephone number listed on the inside back cover. As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering.|/GUIDE 129: FLAMMABLE LIQUIDS (Polar/Water-Miscible/Noxious)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection.|For more DOT Emergency Guidelines (Complete) data for ISOPROPYL ACETATE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

Isopropyl acetate irritates the eyes and upper respiratory tract.

Permissable Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 250 ppm (950 mg/cu m).|Vacated 1989 OSHA PEL TWA 250 ppm (950 mg/cu m); STEL 310 ppm (1185 mg/cu m) is still enforced in some states.

After reviewing available published literature, NIOSH provided comments to OSHA on August 1, 1988, regarding the "Proposed Rule on Air Contaminants" (29 CFR 1910, Docket No. H-020). In these comments, NIOSH questioned whether the PELs proposed for isopropyl acetate [TWA 250 ppm; STEL 310 ppm] were adequate to protect workers from recognized health hazards.

Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.

Fireproof. Separated from oxidants, strong acids and strong bases. Dry. Keep in a well-ventilated room. Store in an area without drain or sewer access.

A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.

The substance may be irritating to the eyes, skin and respiratory tract. Exposure far above the OEL could cause lowering of consciousness.

The substance defats the skin, which may cause dryness or cracking.

NO open flames, NO sparks and NO smoking. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling. See Chemical Dangers

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety spectacles.

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Isopropyl acetate is produced, as an intermediate or final product, by process units covered under this subpart.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 0 - Materials that in themselves are normally stable, even under fire conditions.| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.

URBAN/SUBURBAN: Isopropyl acetate was detected in 1 of 4 samples in the air surrounding the Kin-Buc Waste Disposal site, NJ, 1976, at an estimated concn of 6.5 ug/cu-m(1). Isopropyl acetate was qualitatively detected in the air of the Netherlands and it was described as one of the principal compounds emitted to the air(2). SOURCE DOMINATED: Isopropyl acetate was found in air samples obtained in the industrialized Kanawha Valley, WV, 1977, concn unknown(3).

Isopropyl acetate was identified as having an average concn of 0.4% (w/w) in 29 printer's inks(1).

LD50 Rat oral 3.0 g/kg /From table/|LD50 Rabbit oral 6.95 g/kg /From table/|LD50 Rat oral 6.75 g/kg|LD50 RABBIT SKIN PENETRATION 20000 PPM

Employees /with chronic respiratory, skin, liver, or kidney diseases may be/ at increased risk from isopropyl acetate.

Isopropyl acetate has been detected as a volatile constituent of grape juice(1), nectarines(2), and apples(3). It has also been detected in the volatiles from cold-stored milk(4).

Isopropyl acetate's production and use as a fragrance ingredient(1), its use in the manufacture of plastics, artificial leather, dopes, films, cements, in the recovery of acetic acid from aqueous solutions, as a solvent for nitrocellulose, cellulose acetate (of low viscosity), and a wide range of oils, fats, waxes, gums and natural and synthetic resins(2), may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 15(SRC), determined from a water solubility of 29,000 mg/l(2) and a regression-derived equation(3), indicates that isopropyl acetate is expected to have very high mobility in soil(SRC). Volatilization of isopropyl acetate from moist soil surfaces is expected to be important(SRC) given a Henry's Law constant of 2.78X10-4 atm-cu m/mole(4). The potential for volatilization of isopropyl acetate from dry soil surfaces may exist(SRC) based on a vapor pressure of 60.4 mm Hg(5,SRC). Isopropyl acetate was determined to have a 5 day BOD of 61% using a settled domestic wastewater seed, and BOD's of 72%, 74% and 76% after 10, 15 and 20 days, respectively(6). When the same inoculum was added to synthetic sea water, the 5, 10, 15 and 20 day BOD's were 14%, 39%, 43%, 49%, respectively(6).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 15(SRC), determined from a water solubility of 29,000 mg/l(2,SRC) and a regression-derived equation(3), indicates that isopropyl acetate is not expected to adsorb to suspended solids and sediment in water(SRC). Isopropyl acetate is expected to volatilize from water surfaces(3,SRC) based upon a Henry's Law constant of 2.78X10-4 atm-cu m/mole(4,SRC). Estimated volatilization half-lives for a model river and model lake are 6 hours and 5 days, respectively(3,SRC). A base-catalyzed second-order hydrolysis rate constant of 9.1X10-2 L/mol-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 2.4 years and 88 days at pH values of 7 and 8, respectively(2,SRC). According to a classification scheme(6), an estimated BCF of 2(3,SRC), from the water solubility(2,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Isopropyl acetate was determined to have a 5 day BOD of 61% using a settled domestic wastewater seed, and BODs of 72%, 74% and 76% after 10, 15 and 20 days, respectively(7). When the same inoculum was added to synthetic sea water, the 5, 10, 15 and 20 day BOD's were 14%, 39%, 43%, 49%, respectively(7).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), isopropyl acetate, which has a vapor pressure of 60.4 mm Hg at 25 °C(2,SRC), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase isopropyl acetate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 4.6 days(3,SRC).

The rate constant for the vapor-phase reaction of isopropyl acetate with photochemically-produced hydroxyl radicals has been determined to be 3.4X10-12 cu-cm/molc sec at 25 °C(1,SRC). This corresponds to an atmospheric half-life of about 4.7 hours at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1,SRC). A base-catalyzed second-order hydrolysis rate constant of 9.1X10-2 L/mol-sec(SRC) was estimated using a structure estimation method(2); this corresponds to half-lives of 2.4 years and 88 days at pH values of 7 and 8, respectively(2,SRC). An experimental rate constant for the aqueous reaction of isopropyl acetate with peroxy radicals at 30 °C has been determined to be 2.4X10-3 l/mole-sec(3); this corresponds to a half-life of greater than 9000 years(SRC) using an oxidant concn of 1X10-9 mole/l(4). The atmospheric photo-oxidation potential of isopropyl acetate, based on a 5 tiered rating system and determined in smog chamber studies, was assigned as Class II, low reactivity(5). This ranking system assigns compounds with negligible reactivity, such as methane, as class I and highly reactive dienes as class V(5). The relative rate for the photo-oxidation of isopropyl acetate in a smog chamber was 0.4 times less reactive than toluene(6).

An estimated BCF of 2 was calculated for isopropyl acetate(SRC), using a water solubility of 29,000 mg/l(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests that bioconcentration in aquatic organisms is low(SRC).

The Koc of isopropyl acetate is estimated as approximately 15(SRC), using a measured water solubility of 29,000 mg/l(1) and a regression-derived equation(2,SRC). According to a classification scheme(3), this estimated Koc value suggests that isopropyl acetate is expected to have very high mobility in soil(SRC).

The Henry's Law constant for isopropyl acetate has been determined to be 2.78X10-4 atm-cu m/mole(1). This value indicates that isopropyl acetate is expected to volatilize from water surfaces(3,SRC). Based on this Henry's Law constant, the estimated volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec) is estimated as approximately 6 hours(3,SRC). The estimated volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec) is estimated as approximately 5 days(3,SRC). Isopropyl acetate's Henry's Law constant(1,SRC) indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of isopropyl acetate from dry soil surfaces may exist(SRC) based on a vapor pressure of 60.4 mm Hg(2).

DRINKING WATER: isopropyl acetate was qualitatively detected in U.S. drinking water supplies(1). Isopropyl acetate was detected, but not quantified, in drinking concentrates from Ottumwa, IA(2).

Isopropyl acetate has been identified as a component of Concord grape juice essence(1). It was detected in a headspace analysis of intact nectarines, but it was not found in samples of the blended fruit(2). Isopropyl acetate was identified as a volatile flavor component of Kogyoke apples(3).|ISOPROPYL ACETATE IS REPORTED TO BE USED IN NON-ALCOHOLIC BEVERAGES @ 16 PPM, IN ICE CREAM, ICES, ... @ 17 PPM, IN CANDY @ 58 PPM, & IN BAKED GOODS @ 75 PPM.

Isopropyl acetate has been detected in the volatiles from cold-stored milk(1).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 125,376 workers (37,419 of these are female) are potentially exposed to isopropyl acetate in the US(1). Occupational exposure to isopropyl acetate may occur through inhalation and dermal contact with this compound at workplaces where isopropyl acetate is produced or used(SRC). The general population will be exposed to isopropyl acetate via inhalation of ambient air and volatiles of grape juice, nectarines, apples and milk, ingestion of drinking water, and dermal contact with vapors, food and other products containing isopropyl acetate(SRC).

IT IS ABSORBED THROUGH LUNG, GASTRO-INTESTINAL TRACT & SKIN OF ANIMALS.

Vapors irritate eyes and respiratory tract; high concentrations can be anesthetic. Liquid irritates eyes but causes no serious injury; may cause dermatitis; no serious effects if swallowed. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. Volatile chemicals have a high risk of being aspirated into the victim's lungs during vomiting which increases the medical problems. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)|(See procedures)

Fresh air, rest. Refer for medical attention.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

For basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Esters and related compounds/|For advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: To keep open, "minimal flow rate"/. Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Consider drug therapy for pulmonary edema ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Esters and related compounds/

AMONGST WORKERS OCCUPATIONALLY EXPOSED TO ... /ISOPROPYL ACETATE/, THERE HAVE BEEN CASES OF CONJUNCTIVAL IRRITATION & REPORTS OF A FEELING OF CONSTRICTION OF CHEST & COUGHING; HOWEVER, NO CASES OF PERMANENT OR SYSTEMIC EFFECTS HAVE BEEN FOUND IN EXPOSED WORKERS. REPEATED CONTACT OF THE LIQ WITH THE SKIN MAY LEAD TO DEFATTING AND CRACKING.|ISOPROPYL ACETATE IS AN IRRITANT OF MUCOUS MEMBRANES BUT ONLY TO SLIGHT EXTENT; IT IS ALSO /SRP: CNS DEPRESSANT/ ... BUT LESS SO THAN N-ISOMER. ... NO SYSTEMIC INJURY HAS BEEN REPORTED ... .|Isopropyl acetate irritates the eyes and upper respiratory tract. ... No chronic systemic effects have been reported in humans.|Overexposure to isopropyl acetate may cause irritation of the eyes, nose and throat. Severe overexposure may cause weakness, drowsiness, and unconsciousness.|For more Human Toxicity Excerpts (Complete) data for ISOPROPYL ACETATE (6 total), please visit the HSDB record page.

acetic acid 1-methylethyl ester

The substance can be absorbed into the body by inhalation of its vapour and by ingestion.|inhalation, ingestion, skin and/or eye contact

irritation eyes, skin, nose; dermatitis; In Animals: narcosis

Cough. Sore throat. Headache. Drowsiness.

Redness. Dry skin.

Redness. Pain.

Eyes, skin, respiratory system, central nervous system

70% IN GENERAL COATING SOLVENT USE; 20% AS A PRINTING INK SOLVENT; 10% AS AN INT AND IN MISC APPLICATIONS (1968)|Printing inks, 40%; Coatings, 40%; Miscellaneous solvent uses, 20% (1982)

Grades or Purity: 95-99+%|Grades: 95%; 85 to 88%

All other basic organic chemical manufacturing|Acetic acid, 1-methylethyl ester: ACTIVE|FEMA NUMBER 2926

Analyte: Isopropyl acetate. Matrix: Air. Procedure: Adsorption on charcoal, desorption with carbon disulfide, gas chromatography. Range: 446-1870 mg/cu m. Precision 0.067; Sample size: 8 liters.|Gas chromatography of volatile flavors and solvents.|Gas chromatography-mass spectrometry used for the determination of volatile substances in apples and strawberries.|NIOSH Method 1454: Isopropyl Acetate by GC/FID; Determination of Isopropyl Acetate by Gas Chromatography with Flame Ionization; GC flame ionization detection, workplace air, detection limit of 1.0 mg/cu-m.

Food additives -> Flavoring Agents|Flavouring Agent -> FLAVOURING_AGENT; -> JECFA Functional ClassesFood Additives -> EXTRACTION_SOLVENT; -> JECFA Functional Classes|Flavoring Agents -> JECFA Flavorings Index|Fire Hazards -> Flammable - 3rd degree|Cosmetics -> Solvent

Flavoring Agents|Flavouring Agent -> FLAVOURING_AGENT; Food Additives -> EXTRACTION_SOLVENT;