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Retinol

Retinol structure

CAS No:
68-26-8
Formula:
C20H30O
Chemical Name:
Retinol
Synonyms:
Retinol;Retinol,all-trans-;Acon;Afaxin;Agiolan;Alphalin;Alphasterol;Anatola;Anti-Infective vitamin;Antixerophthalmic vitamin;Anatola A;Apexol;Aquasynth;Aoral;Atav;Avibon;Avita;Avitol;Biosterol;Disatabs Tabs;Dofsol;Epiteliol;Hi-A-Vita;Lard Factor;Myvpack;2,4,6,8-Nonatetraen-1-ol,3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-,(all-E)-;Oleovitamin a;Ophthalamin;Prepalin;Testavol;Vaflol;Vi-Alpha;Vitamin A1;Vitamin A1 alcohol;Vitpex;Vogan;all-trans-Retinol;Vitamin A alcohol;all-trans-Vitamin A alcohol;Vitamin A alcohol,all-trans-;Vitamin A1 alcohol,all-trans-;Vitamin A1,all-trans-;Axerophthol;trans-Retinol;all-trans-Retinyl alcohol;Apostavit;Axerol;Dohyfral A;Nio-A-Let;Vitavel A;Vogan-Neu;trans-Vitamin A alcohol;β-Retinol;Vitamin A;Plivit A;A-Mulsal;Agoncal;Alcovit A;Veroftal;A-Vi-Pel;Bentavit A;all-trans-Vitamin A;(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol;all-trans-Vitamin A1;Thalasphere;Cylasphere;Aquasol A Parenteral;A-Sol;Vi-Dom-A;A-Vitan;NSC 122759;Retinol 50C;Retinyl A;Tegosphere VitA;Tagravit R 1;Riken Dry A-S 200PT;5979-23-7;13123-33-6;17104-91-5
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Retinol, also known as Vitamin A1, has pleiotropic functions including vison, immunity, hematopoiesis, reproduction, cell differentiation/growth, and development.

Retinol Basic Attributes

Molecular Weight：

286.45

Exact Mass：

286.45

EC Number：

200-683-7

HScode：

3004500000

Characteristics

PSA：

20.2

XLogP3：

5.68

Appearance：

yellow to orange crystalline

Density：

1.0±0.1 g/cm3

Melting Point：

62-64 °C

Boiling Point：

137-138 °C @ Press: 1 x 10^-6 Torr

Flash Point：

-26 °C

Refractive Index：

1.549

Water Solubility：

Practically insoluble inwaterorglycerol; soluble in absolute alcohol,methanol,℃hloroform, ether, fats and oils.Sol in ethanol and acetone and benzene

Storage Conditions：

2-8°C

Vapor Pressure：

7.5X10-8 mm Hg at 25 deg C /Estimated/

Toxicity：

LD50 (10 day) in mice (mg/kg): 1510 i.p.; 2570 orally (Kamm)

Safety Information

Transport codes：

UN 1208 3/PG 2

wgk germany：

hazard class code：

22-38-67-65-62-51/53-48/20-11-43-61-63-36/38

safety instructions：

36/37-61-62-45-53-16-33-29-9-36/37/39-26

RTECS Number：

VH6750000

Marks：

Xn,N,F,T

Stability/Shelf Life：

Stable, but light and air sensitive. Incompatible with strong acids, strong oxidizing agents.

Precautionary statement(s)：

P201-P280-P305 + P351 + P338-P308 + P313

Hazard Statements：

H317-H319-H360-H413

Retinol Use and Manufacturing

Methods of Manufacturing

Vitamin A can be refined from cod liver oil by molecular distillation and chromatography, but the method of obtaining the finished product is chemical synthesis. Usually Iserl route (ie tetradecaldehyde route) is used, that is, β-ionone and ethyl monochloroacetate are condensed in sodium methoxide medium, hydrolyzed in sodium hydroxide and methanol, and decarboxylated to obtain tetradecaldehyde. In addition, sodium acetylene and methyl ketene are condensed below -40°C to form 3-methylpentyne (4) ene (2) alcohol (1), which is then subjected to Grignard reaction with ethyl magnesium olfactory to make double olfactory magnesium compound , Followed by condensation and hydrolysis with tetradecaldehyde to obtain hydroxydehydrovitamin A, and then catalyzed hydrogenation to obtain hydroxyvitamin A, and acetyl chloride in pyridine to obtain hydroxyvitamin acetate, and then sniff under alkaline (soda ash) conditions Vitamin acetate can be obtained by chemical deodorization.

Uses

Atracurium Besilate intermediate

Material

Palmitic acid

1-Butanol

Ethyl bromide

Price Analysis

Make your Retinol purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Retinol prices .

Drug Function and Efficacy

It constitutes a variety of coenzymes, participates in the metabolism, utilization and synthesis of a variety of substances, promotes bone growth, maintains the structural integrity of epithelial tissue, and maintains normal growth and development

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Multivitamin tablets
Ingredients	12 vitamins: Vitamin A (4000 IU) 1.2 mg; Vitamin B1 1.6 mg; Vitamin B2 1.8 mg; Vitamin B6 2.6 mg; Vitamin B12 4.0 mg; Vitamin C 0.1 g; Vitamin D3 (500 IU) 12.5 micrograms; Vitamin E 15 mg; Biotin 0.2 mg; Folic acid 0.8 mg; Nicotinamide 19 mg; Calcium pantothenate 10 mg. 7 minerals and trace elements: Calcium 0.125 g; Magnesium 0.1 g; Phosphorus 0.125 g; Copper 1 mg; Iron 60 mg; Manganese 1 mg; Zinc 7.5 mg;
Indication	1. It should not be used with tetracycline drugs. If necessary, the two drugs should be taken at least two hours apart. 2. It should not be used with other drugs containing vitamin A and vitamin D. 3. This product should not be used with carbamazepine, phenytoin, primidone and barbiturates. 4. If used with other drugs at the same time, drug interactions may occur. Please consult your doctor or pharmacist for details.
Specifications	60s

Liuhe Vitamin Pills
Ingredients	Each pill contains 2500 units of vitamin A, 250 units of vitamin D, 2 mg of vitamin B1, 1 mg of vitamin B2, 30 mg of vitamin C, and 1 mg of niacinamide.
Specifications	Compound (children's type)
Manufacturer	Qingdao Double Whale Pharmaceutical Co., Ltd.

Vitamin AD soft capsule
Ingredients	This product is a compound preparation containing vitamin A and vitamin D
Indication	1 Oral contraceptives can increase the concentration of plasma vitamin A. 2 When taken together with vitamin E, it can increase the absorption of vitamin A, increase its storage in the liver, accelerate its utilization and reduce toxicity, but large amounts of vitamin E can consume the storage of vitamin A in the body. 3 Taking large amounts of vitamin A together with anticoagulants (such as coumarin or indandione derivatives) can lead to a decrease in prothrombin. 4 Cholestyramine, mineral oil, neomycin, and sucralfate can interfere with the absorption of vitamin A in this product. 5 Antacids (such as aluminum hydroxide) can affect the absorption of vitamin A in this product, so they should not be taken together. 6 It should not be taken with injectable calcium preparations or magnesium oxide,
Specifications	Vitamin A 3000 units and Vitamin D 300 units
Manufacturer	Dalian Tianshan Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

DSM Vitimins (Shanghai) Limited

China
Active
Zhejiang NHU Company Ltd.

China
Active

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