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Phospho-L-serine

Phospho-L-serine structure

CAS No:
407-41-0
Formula:
C3H8NO6P
Chemical Name:
Phospho-L-serine
Synonyms:
L-Serine,O-phosphono-;Serine,dihydrogen phosphate (ester),L-;L-Serine,dihydrogen phosphate (ester);Serine phosphate,L-;O-Phosphono-L-serine;O-Phosphorylserine;L-Seryl phosphate;3-O-Phosphoserine;L-Phosphoserine;O-Phospho-L-serine;Serine O-phosphate;L-O-Serine phosphate;O-Phosphoryl-L-serine;Fosforina;L-Serinephosphoric acid;Serine dihydrogen phosphate (ester);L-O-Phosphoserine;Phospho-L-serine;Dexfosfoserine;L-3-Phosphoserine;Seriphos;(S)-2-Amino-3-(phosphonooxy)propanoic acid;(2S)-2-Azaniumyl-3-phosphonooxypropanoate;(2S)-2-Amino-3-(phosphonooxy)propanoic acid;1118-86-1;7331-08-0;72909-32-1;474519-60-3;1388265-65-3
Categories:
Cosmetic Ingredient > Hair Conditioning

Description

O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.

Solid

O-phospho-L-serine is the L-enantiomer of O-phosphoserine. It has a role as an EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, an EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor, an EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor and a mouse metabolite. It is a conjugate acid of an O-phosphonato-L-serine(2-). It is an enantiomer of an O-phospho-D-serine.|The phosphoric acid ester of serine.

Phospho-L-serine Basic Attributes

Molecular Weight：

185.07

Exact Mass：

185.07

EC Number：

206-986-0

NSC Number：

760136

DSSTox ID：

DTXSID1046348

HScode：

2931900090

Characteristics

PSA：

130

XLogP3：

-5.1

Appearance：

White Crystalline Powder

Density：

1.8±0.1 g/cm3

Melting Point：

166 °C (decomp)

Boiling Point：

475.4°C at 760 mmHg

Flash Point：

241.3±31.5 °C

Refractive Index：

1.552

Water Solubility：

H2O: 50 mg/mL hot, clear, colorless to slightly yellow

Storage Conditions：

Store at 0°C

Collision Cross Section：

140.8 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|127.5 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|135.1 Å² [M+Na-2H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|140.9 Å² [M+Na]+

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

21/22

safety instructions：

36/37

Marks：

Precautionary statement(s)：

P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, P501

Hazard Statements：

H314

Drug Information

MeSH Entry Terms：

plasmenylserine

Phospho-L-serine Use and Manufacturing

O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.

Computed Properties

Molecular Weight:185.07
XLogP3:-5.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:4
Exact Mass:185.00892397
Monoisotopic Mass:185.00892397
Topological Polar Surface Area:130
Heavy Atom Count:11
Complexity:186
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Phospho-L-serine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Phospho-L-serine

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