(+)-Boldine
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(+)-Boldine
structure -
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CAS No:
476-70-0
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Formula:
C19H21NO4
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Chemical Name:
(+)-Boldine
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Synonyms:
4H-Dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-,(6aS)-;6aα-Aporphine-2,9-diol,1,10-dimethoxy-;Boldine;4H-Dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-,(S)-;(6aS)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol;(S)-Boldine;1,10-Dimethoxy-6aα-aporphine-2,9-diol;(+)-(S)-Boldine;Boldin;Boldina;(+)-Boldine;(+)-2,9-Dihydroxy-1,10-dimethoxyaporphine;(S)-(+)-Boldine;d-Boldine;NSC 65689;(6AS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
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CAS No:
Description
Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1].
Boldine is an aporphine alkaloid.
Characteristics
62.2
2.32
1.3±0.1 g/cm3
163 °C
529.3±50.0 °C at 760 mmHg
273.9±30.1 °C
1.639
179.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
III
6.1(b)
1544
3
22-36/37/38
1-20-24/25-45-36-26
CE0750000
Xn
P301 + P312 + P330
H302
Drug Information
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Drugs that interrupt transmission at the skeletal neuromuscular junction by causing sustained depolarization of the motor end plate. These agents are primarily used as adjuvants in surgical anesthesia to cause skeletal muscle relaxation. (See all compounds classified as Neuromuscular Depolarizing Agents.)|Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)
boldine
(+)-Boldine Use and Manufacturing
antineoplastic
4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)-: INACTIVE
Human drugs -> Rare disease (orphan)
Computed Properties
Molecular Weight:327.4
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:327.14705815
Monoisotopic Mass:327.14705815
Topological Polar Surface Area:62.2
Heavy Atom Count:24
Complexity:461
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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