Product
Supplier
Encyclopedia
Inquiry
Home > Encyclopedia > (+)-Boldine

(+)-Boldine

(+)-Boldine structure

(+)-Boldine 

structure
  • CAS No:

    476-70-0

  • Formula:

    C19H21NO4

  • Chemical Name:

    (+)-Boldine

  • Synonyms:

    4H-Dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-,(6aS)-;6aα-Aporphine-2,9-diol,1,10-dimethoxy-;Boldine;4H-Dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-,(S)-;(6aS)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol;(S)-Boldine;1,10-Dimethoxy-6aα-aporphine-2,9-diol;(+)-(S)-Boldine;Boldin;Boldina;(+)-Boldine;(+)-2,9-Dihydroxy-1,10-dimethoxyaporphine;(S)-(+)-Boldine;d-Boldine;NSC 65689;(6AS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol

  • Categories:

    Natural Products  >  Alkaloids

Description

Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1].


Boldine is an aporphine alkaloid.

(+)-Boldine Basic Attributes

327.37

327.37

207-509-9

8I91GE2769

29399990

Characteristics

62.2

2.32

1.3±0.1 g/cm3

163 °C

529.3±50.0 °C at 760 mmHg

273.9±30.1 °C

1.639

179.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

III

6.1(b)

1544

3

22-36/37/38

1-20-24/25-45-36-26

CE0750000

Xn

P301 + P312 + P330

H302

Drug Information

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Drugs that interrupt transmission at the skeletal neuromuscular junction by causing sustained depolarization of the motor end plate. These agents are primarily used as adjuvants in surgical anesthesia to cause skeletal muscle relaxation. (See all compounds classified as Neuromuscular Depolarizing Agents.)|Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)

boldine

(+)-Boldine Use and Manufacturing

Uses

antineoplastic

4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)-: INACTIVE

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:327.4
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:327.14705815
Monoisotopic Mass:327.14705815
Topological Polar Surface Area:62.2
Heavy Atom Count:24
Complexity:461
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of (+)-Boldine

Scan the QR Code to Share

Feedback & Suggestions
Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.