2-Fluoro-1-methoxy-4-nitrobenzene

White to light yellow crystalline powder

General procedure: A three-necked flask equipped with an argon inlet and thermometer was loaded with arene 1 or 3—8 (10 mmol) in dry MeCN (15 mL). Then, BTFE (2.0 g, 14 mmol) was added. The mixture was cooled in the argon stream down to –35 °C and XeFStep 4: General procedure: A mixture of 2-fluorobenzamide (1a, 69.5 mg, 0.5 mmol), MeOH (ca. 32.0 mg, 1.0 mmol), KOH (56.0 mg, 1.0 mmol) and DMSO (2.0 mL) in a 25 mL screw-capped thick-walled Pyrex tube was stirred at room temperature for 16 h, and then water (10 mL) was added to the reaction mixture with stirring, and the mixture was extracted with ethyl acetate three times (3 * 10 mL). The combined organic phases were dried over Na3, 4-difluoronitrobenzene (31.88, 0.2111001), high purity NaOH (168, 0.4111001), methanol (88, 0.25mo 1), DMSO (200 mL) was added to the reactor and the reaction was stirred at 20 ° C for 12 hours. After completion of the reaction, 800 mL of ethyl acetate was added to the system and diluted 5 times with 200 mL of saturated brine. The organic phase was separated and dried over anhydrous sodium sulfateAfter which it was filtered, evaporated to dryness, and then it was loaded onto a silica gel column to separate petroleum ether: ethyl acetate = 4: 1 (volume) Was eluted as an eluent until the product appeared, the solution containing the product was collected and evaporated to dryness. After drying with a vacuum chestnut, 3-fluoro-4-methoxy nitrobenzene pure product, the yield of 57percent.

Molecular Weight:171.13
XLogP3:2.3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:171.03317122
Monoisotopic Mass:171.03317122
Topological Polar Surface Area:55
Heavy Atom Count:12
Complexity:171
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes