2-Isopropoxyethanol

104.15

104.15

1732184

203-685-6

9L4RL5EKZC

1491

1259

2929|1993

DTXSID4047466

COLORLESS LIQUID|Colorless liquid.

2909 44 00

29.5

0.05

Ethylene glycol isopropyl ether appears as a clear liquid. Density 0.903 g / cm3. Flash point 114°F. An irritant.

0.9030 g/cm³ @ Temp: 20 °C

-60 °C

144 °C @ Press: 743 Torr

114 °F

n 20/D 1.41(lit.)

It is soluble in water.

Flammables area

Vapour pressure, kPa at 20°C: 0.44

Relative vapour density (air = 1): 3.6

Oral-Rat LD50: 5660 mg/kg; Oral-Mouse LD50: 4900 mg/kg

In case of fire, high temperature, oxidant is more flammable; burning produces irritating smoke

1.6-13.0%(V)

MILD ETHEREAL ODOR

BITTER TASTE

2.06e-11 cm3/molecule*sec

9.20e-07 atm-m3/mole

Flammable. Oxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164].

Alcohols and Polyols

Peroxidizable Compound

ETHYLENE GLYCOL ISOPROPYL ETHER acts both as an alcohol and ether. May react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.

240 °C

Class IC Flammable Liquid: Fl.P. at or above 73°F and below 100°F.

III

3

UN 2929 6.1/PG 2

1

20/21-36

24/25

KL5075000

Xn

Treasury is ventilated, low temperature and dry; stored separately from oxidant

Explosive when mixed with air

Stable. Incompatible with strong oxidizing agents. Combustible.

P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

H226-H312 + H332-H315-H319

Oxidizers.

Special Hazards of Combustion Products: Emits toxic fumes when heated upon decomposition. (USCG, 1999)|Flammable. Above 44 °C explosive vapour/air mixtures may be formed.|Flammable - 2nd degree, Reactive - 1st degree

|Warning|H312: Harmful in contact with skin [Warning Acute toxicity, dermal]|P261, P264, P271, P280, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P322, P337+P313, P363, and P501|H226 (31.45%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P332+P313, P337+P313, P362, P363, P370+P378, P403+P235, and P501|Aggregated GHS information provided by 672 companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P307+P311, P309+P311, P312, P314, P321, P322, P332+P313, P337+P313, P362, P363, P370+P378, P403+P235, P405, and P501|P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P307+P311, P312, P314, P321, P322, P332+P313, P337+P313, P362, P363, P370+P378, P403+P235, P405, and P501

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 131 [Flammable Liquids - Toxic]: Fully encapsulating, vapor-protective clothing should be worn for spills and leaks with no fire. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. SMALL SPILL: Absorb with earth, sand or other non-combustible material and transfer to containers for later disposal. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Skin: Wear appropriate personal protective clothing to prevent skin contact. Eyes: Wear appropriate eye protection to prevent eye contact. Wash skin: The worker should immediately wash the skin when it becomes contaminated. Remove: Work clothing that becomes wet should be immediately removed due to its flammability hazard(i.e. for liquids with flash point Change: No recommendation is made specifying the need for the worker to change clothing after the work shift. (NIOSH, 2016)|SKIN & EYE PROTECTION SHOULD...BE WORN IF POSSIBILITY OF /CHEMICAL/ CONTACT EXISTS. /GLYCOL & DERIV/|Wear appropriate personal protective clothing to prevent skin contact.|Wear appropriate eye protection to prevent eye contact.|(See protection codes)

MODERATE; CAN REACT WITH OXIDIZING MATERIALS

Explosive limits , vol% in air: 1.6-13

"ALCOHOL" FOAM. WATER MAY BE INEFFECTIVE

SEE ETHERS. ONLY ELECTRICAL EQUIPMENT OF EXPLOSION-PROOF TYPE (GROUP C CLASSIFICATION) IS PERMITTED TO BE OPERATED IN ETHER AREAS. /ETHERS/|...ADVISABLE TO PROTECT PERSONNEL BY ENCLOSING PROCESS OR PROVIDING LOCAL EXHAUST VENTILATION. MAIN HAZARD...THAT OF INGESTION, CAN USUALLY BE PREVENTED BY KEEPING /CHEM/ IN PROPERLY LABELLED CONTAINERS. /GLYCOL & DERIV/|The worker should immediately wash the skin when it becomes contaminated.|Work clothing that becomes wet should be immediately removed due to its flammability hazard.

NIOSH questioned whether the PEL proposed for 2-isopropoxyethanol [TWA 25 ppm] is adequate to protect workers from recognized health hazards.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible.

Cool. Fireproof. Separated from strong oxidants.

A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20 °C.

The substance is irritating to the eyes. The substance is mildly irritating to the skin and respiratory tract.

The substance may have effects on the blood. This may result in anaemia.

NO open flames, NO sparks and NO smoking. Above 44 °C use a closed system, ventilation and explosion-proof electrical equipment.

Use ventilation, local exhaust or breathing protection.

Protective gloves. Protective clothing.

Wear safety goggles.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 0 - Materials that in themselves are normally stable, even under fire conditions.

moderately toxic

NO REPORTS OF ADVERSE EFFECTS FROM THE HANDLING OR USE OF ETHYLENE GLYCOL MONOISOPROPYL ETHER HAVE BEEN MADE. ...THIS MAY BE BECAUSE OF ITS LIMITED USE TO DATE.|...NO DATA AVAILABLE THAT WOULD ALLOW THE ESTABLISHMENT OF A HYGIENIC STANDARD FOR REPEATED EXPOSURE TO VAPORS. IN VIEW OF HIGH TOXICITY.../TO/ ANIMALS, IT WOULD SEEM...PRUDENT TO TAKE PARTICULAR CARE TO PREVENT ALL POSSIBLE EXPOSURE OF HUMAN BEINGS TO THIS MATERIAL...

3. 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB). /ETHYLENE GLYCOL ALKYL (AND ARYL) ETHERS/

THE MATERIAL MAY READILY BE ABSORBED THROUGH THE INTACT SKIN...|WITHIN 24 HR AFTER (14)C-LABELED ISOPROPYL OXITOL (0.993 MG, IP) ADMIN 71% OF THE RADIOACTIVITY HAD BEEN EXCRETED IN THE URINE & 9% IN THE EXPIRED AIR.

MAJOR URINARY METABOLITES OF (14)C-LABELED ISOPROPYL OXITOL (0.993 MG, IP) WERE ISOPROPOXYACETIC ACID, N-ISOPROPOXYACETYLGLYCINE, & ETHANEDIOL (ACCOUNTING FOR 30, 46 & 13% OF URINARY RADIOACTIVITY).

May be harmful by inhalation, ingestion or skin absorption. May cause skin and eye irritation. (USCG, 1999)

Eye: If this chemical contacts the eyes, immediately wash the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately. Contact lenses should not be worn when working with this chemical. Skin: If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately. Breathing: If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform mouth-to-mouth resuscitation. Keep the affected person warm and at rest. Get medical attention as soon as possible. Swallow: If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2016)|(See procedures)

Fresh air, rest.

Remove contaminated clothes. Rinse skin with plenty of water or shower.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

SYMPTOMATOLOGY: 1. CENTRAL NERVOUS DEPRESSION CHARACTERIZED BY TRANSIENT EXHILARATION, DRUNKENNESS, ATAXIA, VERTIGO PROGRESSING TO STUPOR &...COMA, WITH OR WITHOUT TRANSIENT PERIOD OF CONVULSIONS. DEATH FROM RESP ARREST OR...CARDIOVASCULAR COLLAPSE... /ETHYLENE GLYCOL/|SYMPTOMATOLOGY: 2. NAUSEA, VOMITING, ABDOMINAL PAIN, DEHYDRATION, WEAKNESS, MUSCLE TENDERNESS. 3. HYPERPNEA MAY INDICATE EITHER SEVERE METABOLIC ACIDOSIS OR PULMONARY EDEMA. 4. ...CARPOPEDAL SPASM OR OTHER SIGNS OF HYPOCALCEMIC TETANY. /ETHYLENE GLYCOL/|SYMPTOMATOLOGY: 5. LUMBAR PAIN, ALBUMINURIA, HEMATURIA, OLIGURIA PROGRESSING TO ANURIA. 6. ACUTE RENAL FAILURE WITH UREMIA, PERIPHERAL EDEMA, ASCITES, PULMONARY EDEMA, DROWSINESS, CYANOSIS, COMA, & DEATH IN 7 TO 10 DAYS. /ETHYLENE GLYCOL/|SEE GLYCOLS. THERE IS SOME EVIDENCE THAT THE GLYCOL ETHERS ARE MORE TOXIC THAN OTHER MEMBERS OF THE GLYCOL GROUP. /GLYCOLS/|For more Human Toxicity Excerpts (Complete) data for ISOPROPOXYETHANOL (7 total), please visit the HSDB record page.

isopropoxyethanol

The substance can be absorbed into the body by inhalation of its vapour and through the skin.|inhalation, skin absorption, ingestion, skin and/or eye contact

In Animals: irritation eyes, skin; hematuria (blood in the urine), anemia, pulmonary edema

Cough.

MAY BE ABSORBED! Redness.

Redness. Pain.

Eyes, skin, respiratory system, blood

Ethanol, 2-(1-methylethoxy)-: ACTIVE|IN THE PRESENCE OF GLUCOSE, 10% 2-ISOPROPOXYETHANOL PREVENTED SPORE GERMINATION & MYCELIAL GROWTH OF C RESINAE, A PROBLEM ORGANISM IN JET FUEL.

Fire Hazards -> Flammable - 2nd degree, Reactive - 1st degree