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Dihydralazine

Dihydralazine structure

CAS No:
484-23-1
Formula:
C8H10N6
Chemical Name:
Dihydralazine
Synonyms:
Phthalazine,1,4-dihydrazinyl-;Phthalazine,1,4-dihydrazino-;1,4-Phthalazinedione,2,3-dihydro-,dihydrazone;1,4-Dihydrazinylphthalazine;Dihydralazine;1,4-Dihydrazinophthalazine;Nepresol;Nepresolin;Nepressol;Dihydrazinophthalazine;Dihydralazin;C 7441;Cassella 532;Ophthazin;Tonolysin;Hypopresol;NSC 526654;1,4-Bis(hydrazino)phthalazine;(4-Hydrazinylphthalazin-1-yl)hydrazine
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Dihydralazine is a member of phthalazines.|Dihydralazine is under investigation in clinical trial NCT00311974 (The Effect of Dihydralazine on Kidney Function and Hormones in Healthy Individuals).|1,4-Dihydrazinophthalazine. An antihypertensive agent with actions and uses similar to those of HYDRALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p354)

Dihydralazine Basic Attributes

Molecular Weight：

190.21

Exact Mass：

190.21

EC Number：

207-605-0

UNII：

PCU411F5L6

NSC Number：

526654

DSSTox ID：

DTXSID0022935

ATC Code：

C - Cardiovascular system

HScode：

2933990090

Characteristics

PSA：

102

XLogP3：

0.73

Density：

1.6±0.1 g/cm3

Melting Point：

180 °C (decomp)

Boiling Point：

419.9±28.0 °C at 760 mmHg

Flash Point：

207.7±24.0 °C

Refractive Index：

1.810

Vapor Pressure：

1.09E-16mmHg at 25°C

Toxicity：

LD50 i.p. in rats: 1084 mmol/kg (Steiner)

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

Depressan

Dihydralazine Use and Manufacturing

An antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.

Computed Properties

Molecular Weight:190.21
XLogP3:0.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:190.09669434
Monoisotopic Mass:190.09669434
Topological Polar Surface Area:102
Heavy Atom Count:14
Complexity:167
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Blood pressure reduction

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Lophatherum gracile tablets Ⅰ
Ingredients	Dry powder of Luobu Ma decoction, dry powder of wild chrysanthemum decoction, dry powder of Stephania tetrandra decoction, magnesium trisilicate, guanidine sulfate, dihydralazine sulfate, hydrochlorothiazide, promethazine hydrochloride, vitamin B1, vitamin B6, calcium pantothenate.
Indication	Atropine: can partially counteract the antihypertensive effect of Apocynum venetum leaves. Diphenhydramine: can block the antihypertensive effect of Apocynum venetum leaves by more than 50%. Other antihypertensive drugs: Apocynum venetum can be used in combination with external Chinese medicine patches such as Li's Medicinal Patch, Shen's Antihypertensive Patch, and Xuan's Pressure Patch to enhance the antihypertensive effect. For other drug interactions, please consult your doctor or pharmacist.
Specifications	Compound
Manufacturer	Shanxi Linfen Jianmin Pharmaceutical Factory Co., Ltd.

Compound Lophatherum gracile tablets Ⅱ
Ingredients	This product is a compound preparation, and its components are: each tablet contains 43.7 mg of dry powder of Apocynum venetum decoction, 28.5 mg of dry powder of Chrysanthemum indica decoction, 30.7 mg of dry powder of Stephania tetrandra decoction, 15 mg of magnesium trisilicate, 1.3 mg of guanidine sulfate, 1.6 mg of hydralazine sulfate, 1.6 mg of hydrochlorothiazide, 1.05 mg of promethazine hydrochloride, 0.5 g of vitamin B1, 0.5 g of vitamin B6, and 0.25 mg of calcium pantothenate.
Indication	Not yet clear.
Specifications	Compound
Manufacturer	Jilin Xianfeng Technical Pharmaceutical Co., Ltd.

Compound Lophatherum gracile tablets Ⅱ
Ingredients	Dry powder of Luobu Ma decoction, dry powder of wild chrysanthemum decoction, dry powder of Stephania tetrandra decoction, magnesium trisilicate, guanidine sulfate, dihydralazine sulfate, hydrochlorothiazide, promethazine hydrochloride, vitamin B1, vitamin B6, calcium pantothenate.
Indication	Atropine: can partially counteract the antihypertensive effect of Apocynum venetum leaves. Diphenhydramine: can block the antihypertensive effect of Apocynum venetum leaves by more than 50%. Other antihypertensive drugs: Apocynum venetum can be used in combination with external Chinese medicine patches such as Li's Medicinal Patch, Shen's Antihypertensive Patch, and Xuan's Pressure Patch to enhance the antihypertensive effect. For other drug interactions, please consult your doctor or pharmacist.
Specifications	Compound
Manufacturer	Shanxi Jinhuahuixing Pharmaceutical. Co., Ltd.

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Ophthazin

CAS No.: 484-23-1

Grade: Pharmaceutical Grade

Content: 95%

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