Fructose 1,6-bisphosphate
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Fructose 1,6-bisphosphate
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CAS No:
488-69-7
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Formula:
C6H14O12P2
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Chemical Name:
Fructose 1,6-bisphosphate
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Synonyms:
D-Fructose,1,6-bis(dihydrogen phosphate);Fructose,1,6-bis(dihydrogen phosphate),D-;Fructose 1,6-diphosphate;D-Fructose 1,6-diphosphate;Harden-Young ester;FDP;Fructose 1,6-bisphosphate;Diphosphofructose;D-Fructose 1,6-bisphosphate;Fructose 1,6-bis(dihydrogen phosphate);Esafosfan;Esafosfina;D-Fructose 1,6-biphosphate;Fosfructose;125740-83-2;77-82-7;4004-40-4
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Categories:
Active Pharmaceutical Ingredients > Fluid, Electrolyte, and Acid-base Balance
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CAS No:
Description
Fosfructose is a cytoprotective natural sugar phosphate for the potential treatment of cardiovascular ischemia, sickle cell anemia and asthma.
1,6-di-o-phosphonohex-2-ulofuranose is a phospho sugar.
Fructose 1,6-bisphosphate Basic Attributes
340.115682
340.12
207-683-6
57553
DTXSID40274283
C - Cardiovascular system
2940000000
Drug Information
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume. (See all compounds classified as Cardiovascular Agents.)|Biologically active substances whose activities affect or play a role in the functioning of the immune system. (See all compounds classified as Immunologic Factors.)|Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)
fructose 1,6-bisphosphate
Fructose 1,6-bisphosphate Use and Manufacturing
Cardiovascular system medication.
D-Fructose, 1,6-bis(dihydrogen phosphate): INACTIVE
Computed Properties
Molecular Weight:340.12
XLogP3:-5.6
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:6
Exact Mass:339.99604987
Monoisotopic Mass:339.99604987
Topological Polar Surface Area:203
Heavy Atom Count:20
Complexity:428
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Dextrorotatory fructose 1,6-diphosphate (FDP) is an intermediate product of glycolysis. It regulates several enzymatic reactions in cells by activating phosphofructokinase, pyruvate kinase and lactate dehydrogenase. FDP can act on cell membranes, promote the cell's uptake of circulating potassium and stimulate the production of high-energy phosphate and 2,3-diphosphoglycerol in cells. In addition, FDP can reduce hemolysis of erythrocytes caused by mechanical trauma and inhibit the production of oxygen free radicals caused by chemical stimulation. In COPD patients, FDP is beneficial for treatment, especially for strengthening respiratory intensity, which is manifested as an increase in PImax, PaO2 and tolerance.
Registered Holders
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Shanghai SPH New ASIA Pharmaceutical Co., Ltd.
Active
China
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Jiangsu Jinrui Pharmaceutical Co., Ltd.
Active
China
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Hainan Changan International Pharmaceutical Co., Ltd.
Active
China
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Learn More Other Chemicals
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Glucose 1,6-bisphosphate
10139-18-1
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Fructose 1,6-diphosphate trisodium salt Formula
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Fructose 6-phosphate Formula
643-13-0
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Fructose 1-phosphate Formula
15978-08-2
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Fructose Structure
57-48-7
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Sodium acetate Structure
127-09-3
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