Butyrophenone
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Butyrophenone
structure -
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CAS No:
495-40-9
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Formula:
C10H12O
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Chemical Name:
Butyrophenone
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Synonyms:
1-Butanone,1-phenyl-;Butyrophenone;1-Phenyl-1-butanone;n-Butyrophenone;Propyl phenyl ketone;Phenyl propyl ketone;1-Benzoylpropane;Butanophenone;n-Propyl phenyl ketone;NSC 8463;Phenyl n-propyl ketone
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CAS No:
Description
colourless to yellow liquid
Butyrophenone is synthetic agents containing the phenyl-1-butanone group, most Butyrophenones are neuroleptic (antipsychotic) drugs, such as haloperidol, droperidol, or azaperone, that control schizophrenic symptoms (hallucinations, delusions, dementia). Most antipsychotic agents interfere with neurotransmitter functions, usually blocking dopamine receptors, and induce behavioral, endocrine, motor-kinetic effects. (NCI04)
Butyrophenone Basic Attributes
148.2
148.20
508305
207-799-7
186I11WB5B
8463
DTXSID3047059
C323
29143900
Characteristics
17.1
2.5
Clear colorless to yellow Liquid
1.001 g/cm3 @ Temp: 40 °C
12 °C
228.5 °C
192 °F
1.503
Insoluble in water.
Store below +30°C.
0.0732mmHg at 25°C
Safety Information
NONH for all modes of transport
3
41-43
26-36/37/39-24/25-23
Xi
Stable. Combustible. Incompatible with strong oxidizing agents.
P280-P305 + P351 + P338 + P310-P333 + P313
H317-H318
Butyrophenone Use and Manufacturing
By the reaction of butyryl chloride and benzene. Under stirring, butyryl chloride was added dropwise to the mixture of benzene and anhydrous aluminum trichloride. The reaction was kept for 3-4 hours and then cooled to below 40°C. The reactants were layered in a mixture of ice water and hydrochloric acid. The 5% sodium hydroxide solution and water are washed successively, until they are neutral, and after drying, the benzene is recovered, and finally fractionated. The 182.5-184.5°C fraction collected is the finished product.
Intermediates of Liquid Crystals
1-Butanone, 1-phenyl-: ACTIVE
Food additives -> Flavoring Agents
Flavoring Agents
Computed Properties
Molecular Weight:148.20
XLogP3:2.5
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:3
Exact Mass:148.088815002
Monoisotopic Mass:148.088815002
Topological Polar Surface Area:17.1
Heavy Atom Count:11
Complexity:123
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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