Dihydrofolic acid
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Dihydrofolic acid
structure -
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CAS No:
4033-27-6
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Formula:
C19H21N7O6
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Chemical Name:
Dihydrofolic acid
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Synonyms:
L-Glutamic acid,N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-;Glutamic acid,N-[p-[[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-,L-;L-Glutamic acid,N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-;N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid;Dihydrofolic acid;7,8-Dihydrofolic acid;7,8-Dihydro-L-folic acid;NSC 165989;188205-86-9
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CAS No:
Description
Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid.
Safety Information
NONH for all modes of transport
3
36/37/38
26-36
Xi: Irritant;
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (97.44%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Dihydrofolic acid Use and Manufacturing
antidote to methotrexate toxicity Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).
Computed Properties
Molecular Weight:443.4
XLogP3:-0.9
Hydrogen Bond Donor Count:7
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:9
Exact Mass:443.15533142
Monoisotopic Mass:443.15533142
Topological Polar Surface Area:208
Heavy Atom Count:32
Complexity:889
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of Dihydrofolic acid
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