2-Amino-5-bromo-4,6-dimethylpyrimidine

2-Amino-5-bromo-4, 6-dimethylpyrimidine (3):; To a stirred solution containing 4.3 lg (34.75 mmol) of 2-amino-4, 6-dimethylpyrimidine (2) in 150 mL of acetonitrile were added 6.15g (52.12 mmol) of N-bromosuccinimide. The reaction mixture was stirred at room temperature under argon atmosphere for 3 h. The formed precipitate was filtered and dried to afford the expected product as a white solid: yield 5.93g (83percent).1H-NMR(CDC1To a stirred solution containing 4.31 g (34.8 mmol) of 2-amino-4, 6-dimethylpyrimidine (4) in 150 mL of acetonitrile was added 6.15 g (52.1 mmol) of N-bromosuccinimide. The reaction mixture was stirred at 23 °C for 3 h. The formed precipitate was filtered and dried to afford 5 as a colorless solid: yield 5.93 g (83percent); mp 183-185 °C; silica gel TLC R2-Amino-5-bromo-4, 6-dimethylpyrimidine (3):; To a stirred solution containing 4.3 lg (34.75 mmol) of 2-amino-4, 6-dimethylpyrimidine (2) in 150 mL of acetonitrile were added 6.15g (52.12 mmol) of N-bromosuccinimide. The reaction mixture was stirred at room temperature under argon atmosphere for 3 h. The formed precipitate was filtered and dried to afford the expected product as a white solid: yield 5.93g (83percent).1H-NMR(CDC1To a stirred solution containing 4.31 g (34.8 mmol) of 2-amino-4, 6-dimethylpyrimidine (4) in 150 mL of acetonitrile was added 6.15 g (52.1 mmol) of N-bromosuccinimide. The reaction mixture was stirred at 23 °C for 3 h. The formed precipitate was filtered and dried to afford 5 as a colorless solid: yield 5.93 g (83percent); mp 183-185 °C; silica gel TLC R

Molecular Weight:202.05
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Exact Mass:200.99016
Monoisotopic Mass:200.99016
Topological Polar Surface Area:51.8
Heavy Atom Count:10
Complexity:108
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes