Tris(2-chloroethyl) phosphite

269.49

269.49

205-397-6

66XM91RPZK

6514

2810

DTXSID0026258

Colorless liquid

2920901900

27.7

1.51 (est)

Tris(2-chloroethyl)phosphite is a clear colorless liquid. (NTP, 1992)

1.353 g/cm³ @ Temp: 20 °C

119 °C @ Press: 0.15 Torr

375 °F

n20/D 1.487(lit.)

In water, 950 mg/L at 25 deg C (est)

-20°C

3.0X10-4 mm Hg at 25 deg C (est)

9.32 (Air= 1)

Characteristic odor

Henry's Law constant = 1.1X10-6 atm-cu m/mol at 25 °C (est)

Hydroxyl radical reaction rate constant = 2.2X10-11 cu cm/molec-sec at 25 °C (est)

Unstable to heat, moisture and prolonged exposure to air. Decomposes in water.

Halogenated Organic Compounds

Water-Reactive

TRIS(2-CHLOROETHYL)PHOSPHITE is unstable to heat, moisture and prolonged exposure to air. Hydrolyzes in water. Reacts vigorously with oxidizing agents. Undergoes vigorous isomerization (NTP, 1992).

Self reacts exothermally when heated above 130 °C.

III

6.1(b)

UN 2810 6.1/PG 3

3

45-21-25-36/37/38-23/24/25-46

53-26-36/37/39-45-36/37

KK2810000

T

P201-P260-P280-P284-P301 + P310-P305 + P351 + P338

H301 + H311-H315-H319-H330-H335-H340-H350

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Can react vigorously with oxidizing materials.

EPA/Office of Pollution Prevention and Toxics; High Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans on 2-Chloroethanol phosphite.[Available from, as of June 15, 2009: http://iaspub.epa.gov/oppthpv/quicksearch.display?pChem=102294]

This chemical is combustible. (NTP, 1992)

|Danger|H301+H311 (40.86%): Toxic if swallowed or in contact with skin [Danger Acute toxicity, oral; acute toxicity, dermal]|P201, P202, P260, P261, P264, P270, P271, P280, P281, P284, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 98 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with alcohol followed by washing with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this material from exposure to air, and store it in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Combustible|Slight when exposed to heat or flame

Water, foam, carbon dioxide, and dry chemical

Undergoes intramolecular isomerization at higher temperatures, exposure to air should be minimum.

SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a POTW is acceptable only after review by the governing authority. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must meet Hazardous Material Criteria for disposal.

LD50 Rat oral 100 mg/kg|LD50 Rabbit skin 810 mg/kg|LD50 Rat oral 131 mg/kg

Tris(2-chloroethyl) phosphite's production and use as a chemical intermediate and as a component of vinyl stabilizers, grease additives, flameproofing compositions(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a rapid hydrolysis of 100% in 20 minutes at pH 7(1), adsorption to soil and volatilization from moist soil are not expected to be an important environmental fate processes(SRC). Tris(2-chloroethyl) phosphite is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.0X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Biodegradation data were not available(SRC, 2009).|AQUATIC FATE: Adsorption to suspended solids and sediment, volatilization, and bioconcentration of tris(2-chloroethyl) phosphite in water are not expected to be important environment fate processes due to 100% hydrolysis in 20 minutes at pH 7 and 23 °C(1). Biodegradation data were not available(SRC, 2009).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tris(2-chloroethyl) phosphite, which has an estimated vapor pressure of 3.0X10-4 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tris(2-chloroethyl) phosphite is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 17 hours(SRC), calculated from its rate constant of 2.2X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Tris(2-chloroethyl) phosphite does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Tris(2-chloroethyl) phosphite hydrolyzes rapidly in water(1), as indicated by a half-life of 5.1 hours (degradation rate constant of 3.81X10-5 /sec) at pH 9(2). At pH 4 the compound degrades immediately to diethyl phosphonate. Products identified at pH 7 were diethyl phosphonate and ethyl phosphonate and at pH 9, triethyl phosphite, diethyl phosphonate and ethyl phosphonate. Reaction with hydroxy radicals and photogradation are not expected to be important environmental fate processes due to very rapid hydrolysis rate(2).|The rate constant for the vapor-phase reaction of tris(2-chloroethyl) phosphite with photochemically-produced hydroxyl radicals has been estimated as 2.2X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 17 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Tris(2-chloroethyl) phosphite does not contain chromophores that absorb at wavelengths >290 nm(2) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Bioconcentration of tris(2-chloroethyl) phosphite is not expected to be important environmental fate processes due to 100% hydrolysis in 20 minutes at pH 7 and 23 °C(1).

Based on a rapid hydrolysis of 100% in 20 minutes at pH 7(1), adsorption to soil and sediment are not expected to be an important environmental fate processes(SRC).

Volatilization of tris(2-chloroethyl) phosphite from water surfaces or moist soil surfaces is not expected to be important environmental fate processes due to 100% hydrolysis in 20 minutes at pH 7 and 23 °C(1). Tris(2-chloroethyl) phosphite is is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.0X10-4 mm Hg(SRC), determined from a fragment constant method(2).

RAIN/SNOW/FOG: Tris(2-chloroethyl)phosphite was tested for but not detected in a study of snow samples collected during March 2003 in northern Sweden at a road intersection and an airport, designed to implicate traffic as a source of organophosphorus flame retardants and plasticizers in the outdoor environment(1).

Occupational exposure to tris(2-chloroethyl) phosphite may occur through inhalation and dermal contact with this compound at workplaces where tris(2-chloroethyl) phosphite is produced or used. (SRC)

SYMPTOMS: This material causes irritation of the eyes, skin and mucous membranes. ACUTE/CHRONIC HAZARDS: Vapors from this material are extremely irritating to the eyes, skin and mucous membranes. It is also easily absorbed through the skin and may cause irritation on contact. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Phosphorus and related compounds/|/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Administer activated charcoal ... . If product was ingested, protect yourself from contact with vomitus as it may cause burns. /Phosphorus and related compounds/|/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose stick or glucometer readings below 50 mg/dl) and administer 50% dextrose if necessary. Draw blood sample before administration ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Phosphorus and related compounds/

Ethanol, 2-chloro-, 1,1',1''-phosphite: ACTIVE|Exposure to air should be minimum. /SRP: Hydrolyzes rapidly/