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Estrone

Estrone structure

CAS No:
53-16-7
Formula:
C18H22O2
Chemical Name:
Estrone
Synonyms:
Estra-1,3,5(10)-trien-17-one,3-hydroxy-;Estrone;3-Hydroxyestra-1,3,5(10)-trien-17-one;Aquacrine;Crinovaryl;Cristallovar;Crystogen;Destrone;Disynformon;Endofolliculina;1,3,5(10)-Estratrien-3-ol-17-one;Estrugenone;Estrusol;Femestrone injection;Femidyn;Folikrin;Folipex;Folisan;Follestrine;Follicular hormone;Folliculin;Follicunodis;Follidrin;Glandubolin;Hiestrone;Hormofollin;Hormovarine;3-Hydroxy-17-keto-estra-1,3,5-triene;Kestrone;Ketodestrin;Ketohydroxyestrin;Kolpon;Menagen;Menformon;Oestrin;Oestroform;Oestrone;Oestroperos;Ovifollin;Perlatan;Solliculin;Theelin;Thelykinin;Thynestron;Wynestron;Unden;3-Hydroxyoestra-1,3,5(10)-trien-17-one;3-Hydroxyestra-1,3,5(10)-triene-17-one;Estrovarin;Estron;Tokokin;Follestrol;Δ1,3,5(10)-Estratrien-3-ol-17-one;(+)-Estrone;Femestrone Inj.;Thelestrin;Fermidyn;NSC 9699;Folliculin (steroid);WAY 164397;Folliculinum;(8R,9S,13S,14S)-3-Hydroxy-13-methyl-6,7,8,9,11,12,13,14,15,16-decahydro-17H-cyclopenta[a]phenanthren-17-one;37242-41-4
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

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Description

Crystalline Solid Estrone is an odorless white crystalline powder.

Estrone Basic Attributes

Molecular Weight：

270.37

Exact Mass：

270.37

EC Number：

200-164-5

HScode：

29335995

Characteristics

PSA：

37.3

XLogP3：

3.13

Appearance：

White to almost white Crystalline Powder or Crystals

Density：

1.236 g/cm³ @ Temp: 25 °C

Melting Point：

260.2 °C

Boiling Point：

154 °C

Flash Point：

9℃

Refractive Index：

165 ° (C=1, Dioxane)

Water Solubility：

H2O: 0.03 g/L

Storage Conditions：

Refrigerator

Vapor Pressure：

2.49X10-10 mm Hg at 25 deg C (est)

Specific rotation：

158 º (c=1, dioxane)

Odor：

Odorless

Safety Information

Packing level：

I; II; III

Transport codes：

UN1230 - class 3 - PG 2 - Methanol, solution

wgk germany：

hazard class code：

45-60-61-64-40-63-39/23/24/25-23/24/25-11

safety instructions：

53-45-36/37-16

RTECS Number：

KG8575000

Marks：

T,F

Stability/Shelf Life：

Stable in air.

Precautionary statement(s)：

P201, P202, P260, P264, P270, P273, P281, P308+P313, P314, P391, P405, P501

Hazard Statements：

H350

Estrone Use and Manufacturing

Methods of Manufacturing

The estrodione is brominated by hydrobromide to obtain the dibromo compound, which is refluxed in 2, 4, 6-trimethylpyridine solution to obtain the crude product, which is then purified by recrystallization from methanol or acetone.

Uses

A metabolite of 17-Estradiol Biochemical research, female hormone drugs. It is an intermediate for the synthesis of ethinyl estradiol; it is mainly used for uterine hypoplasia, menstrual disorders and menopausal disorders. It is an intermediate for the synthesis of ethinyl estradiol drugs. Can cause nausea, vomiting, dizziness, etc. Long-term use can cause excessive endometrial hyperplasia and bleeding. This product is an intermediate of the hormone ethinyl estradiol used in the No. 1 contraceptive.

Computed Properties

Molecular Weight:270.4
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:270.161979940
Monoisotopic Mass:270.161979940
Topological Polar Surface Area:37.3
Heavy Atom Count:20
Complexity:418
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Homeopathic preparation associated with estrogenic activity, used to address symptoms related to ovarian dysfunction.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

ENDOPURE PRO- l-arginine, hypophysis suis, pineal (suis), progesterone, belladonna, chelidonium majus, dioscorea villosa, folliculinum, glandula suprarenalis suis, hypothalamus suis, oophorinum (suis), lilium tigrinum, pulsatilla (vulgaris), sepia, sulphur_liquid
Manufacturer	The Wellness Center for Research and Education, Inc.

ENDOPURE ESTRO- estradiol, estriol, folliculinum, belladonna, chelidonium majus, glandula suprarenalis suis, hydrocortisone (cortisol), hypothalamus suis, oophorinum (suis), pineal (suis), hypophysis (suis), sanguinaria canadensis, lilium tigrinum, pulsatilla (vulgaris), sepia, sulphur_liquid
Manufacturer	The Wellness Center for Research and Education

Registered Holders

QINHUANGDAO ZIZHU PHARMACEUTICAL CO LTD

United States
Active
ZHEJIANG XIANJU JUNYE PHARMACEUTICAL CO LTD

United States
Active
ROUSSELL UCLAF

United States
Inactive

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