(+)-Evodiamine
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(+)-Evodiamine
structure -
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CAS No:
518-17-2
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Formula:
C19H17N3O
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Chemical Name:
(+)-Evodiamine
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Synonyms:
Indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one,8,13,13b,14-tetrahydro-14-methyl-,(13bS)-;Evodiamine;Indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one,8,13,13b,14-tetrahydro-14-methyl-,(S)-;(13bS)-8,13,13b,14-Tetrahydro-14-methylindolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one;Evodiamine,(+)-;(+)-Evodiamine;d-Evodiamine
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.
Evodiamine is a member of beta-carbolines.
Characteristics
39.3
1.64
Fine Powder Color
1.4±0.1 g/cm3
278 °C
575.1±50.0 °C at 760 mmHg
301.6±30.1 °C
1.764
2-8°C
D15 +352° (acetone); D +440° (chloroform)
Safety Information
UN 2811 6.1/PG 3
3
25
45
T
P264, P270, P301+P310, P321, P330, P405, P501
H300
|Danger|H300 (97.5%): Fatal if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.
(+)-Evodiamine Use and Manufacturing
A chemical extracted from Evodia plants, and has been shown to reduce fat uptake.
Computed Properties
Molecular Weight:303.4
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:303.137162174
Monoisotopic Mass:303.137162174
Topological Polar Surface Area:39.3
Heavy Atom Count:23
Complexity:495
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
When combined with berberine in a 1:1 ratio, achieves a 91.5% inhibition rate against HCV
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