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(+)-Evodiamine

(+)-Evodiamine structure

CAS No:
518-17-2
Formula:
C19H17N3O
Chemical Name:
(+)-Evodiamine
Synonyms:
Indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one,8,13,13b,14-tetrahydro-14-methyl-,(13bS)-;Evodiamine;Indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one,8,13,13b,14-tetrahydro-14-methyl-,(S)-;(13bS)-8,13,13b,14-Tetrahydro-14-methylindolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one;Evodiamine,(+)-;(+)-Evodiamine;d-Evodiamine
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Evodiamine is an alkaloid isolated from the fruit of Evodia rutaecarpa Bentham with diverse biological activities including anti-inflammatory, anti-obesity, and antitumor.

Evodiamine is a member of beta-carbolines.

(+)-Evodiamine Basic Attributes

Molecular Weight：

303.36

Exact Mass：

303.36

EC Number：

1308068-626-2

UNII：

C01825BVNL

HScode：

2933990090

Characteristics

PSA：

39.3

XLogP3：

1.64

Appearance：

Fine Powder Color

Density：

1.4±0.1 g/cm3

Melting Point：

278 °C

Boiling Point：

575.1±50.0 °C at 760 mmHg

Flash Point：

301.6±30.1 °C

Refractive Index：

1.764

Storage Conditions：

2-8°C

Specific rotation：

D15 +352° (acetone); D +440° (chloroform)

Safety Information

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

safety instructions：

Marks：

Precautionary statement(s)：

P264, P270, P301+P310, P321, P330, P405, P501

Hazard Statements：

H300

GHS Classification：

|Danger|H300 (97.5%): Fatal if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

evodiamine

(+)-Evodiamine Use and Manufacturing

A chemical extracted from Evodia plants, and has been shown to reduce fat uptake.

Computed Properties

Molecular Weight:303.4
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:303.137162174
Monoisotopic Mass:303.137162174
Topological Polar Surface Area:39.3
Heavy Atom Count:23
Complexity:495
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

When combined with berberine in a 1:1 ratio, achieves a 91.5% inhibition rate against HCV

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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