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Evodiamine

Name: Evodiamine
Brand: Cuicheng Bio
SKU: pr2606011592
Price: 1000 USD
Availability: InStock

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CAS No.:

518-17-2

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-03

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information

Description

Evodiamine (CAS Number: 518-17-2) is a natural indoloquinazoline alkaloid primarily extracted from the unripe fruit of the medicinal plant Evodia rutaecarpa (Wu Zhu Yu). It functions as a highly active, multi-target pharmacological research tool, most celebrated for its capsaicin-like thermogenic actions, potent antitumor activities, and anti-obesity properties.

Key Pharmacological Functions and Mechanisms

Thermogenesis, Lipid Metabolism, and Anti-Obesity Actions: In metabolic research, evodiamine's most distinctive function is acting as a potent TRPV1 receptor agonist. Similar to capsaicin but with significantly less mucosal irritation, it stimulates the sympathetic nervous system to release catecholamines. This molecular trigger heavily upregulates Uncoupling Protein 1 (UCP1), which accelerates heat production (thermogenesis) in brown adipose tissue, promotes white fat breakdown (lipolysis), and prevents fat accumulation.
Antitumor Activity and Multidrug Resistance Reversal: In oncology research, it exhibits selective cytotoxicity against various malignant lines, including colorectal, breast, prostate, and melanoma cancers. It forces G2/M phase cell cycle arrest by downregulating Cyclin B1/Cdc2 complexes and triggers caspase-dependent mitochondrial apoptosis. Additionally, it acts as a Topoisomerase I and II inhibitor and downregulates P-glycoprotein (P-gp), effectively reversing multidrug resistance to act as a chemosensitizer.
Vasodilation and Cardiovascular Protection: Through its activation of endothelial TRPV1 channels, evodiamine stimulates the prolonged secretion of nitric oxide (NO) and Calcitonin Gene-Related Peptide (CGRP). This cascade results in powerful blood vessel dilation, which helps lower systemic blood pressure, improve microcirculation, and shield heart tissue from ischemia-reperfusion injury.
Targeted Anti-Inflammatory Action: It serves as a strong anti-inflammatory agent by blocking the activation of the NF-$\kappa\text{B}$ signaling pathway. This downregulates inducible enzymes (iNOS and COX-2) and suppresses the secretion of pro-inflammatory cytokines (such as TNF-$\alpha $, IL-6, and IL-1$\beta $), protecting vital tissues in models of colitis and acute lung injury.
Neuroprotection and Cognitive Support: Evodiamine readily crosses the blood-brain barrier. In neurodegenerative models, it lowers the accumulation and toxicity of amyloid-beta (A$\beta $) plaques in cerebral tissue. It alleviates chronic neuroinflammation and enhances synaptic plasticity, which helps rescue spatial learning and memory deficits.

Botanical and Quality Control Functions

Official Chemical Marker: Alongside its structural analogue rutaecarpine, evodiamine serves as the definitive HPLC analytical standard required by international pharmacopoeias to evaluate, authenticate, and control the quality and chemical safety of Evodia rutaecarpa extracts and related traditional formulas.

Basic Info

Product Name:

(+)-Evodiamine

Other Name:

Indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one,8,13,13b,14-tetrahydro-14-methyl-,(13bS)-;Evodiamine;Indolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one,8,13,13b,14-tetrahydro-14-methyl-,(S)-;(13bS)-8,13,13b,14-Tetrahydro-14-methylindolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one;Evodiamine,(+)-;(+)-Evodiamine;d-Evodiamine

CAS No.:

518-17-2

Molecular Formula:

C19H17N3O

InChIKeys:

InChIKey=TXDUTHBFYKGSAH-SFHVURJKSA-N

Molecular Weight:

303.36

Exact Mass:

303.36

EC Number:

1308068-626-2

UNII:

C01825BVNL

HScode:

2933990090

Categories:

Circulatory System Drugs

Characteristics

PSA:

39.3

XLogP3:

1.64

Appearance:

Fine Powder Color

Density:

1.4±0.1 g/cm3

Melting Point:

278 °C

Boiling Point:

575.1±50.0 °C at 760 mmHg

Flash Point:

301.6±30.1 °C

Refractive Index:

1.764

Storage Conditions:

2-8°C

Specific rotation:

D15 +352° (acetone); D +440° (chloroform)

See More (+)-Evodiamine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 2, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H300 Fatal if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More (+)-Evodiamine Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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