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Chlorhexidine

Chlorhexidine structure

CAS No:
55-56-1
Formula:
C22H30Cl2N10
Chemical Name:
Chlorhexidine
Synonyms:
2,4,11,13-Tetraazatetradecanediimidamide,N1,N14-bis(4-chlorophenyl)-3,12-diimino-;Biguanide,1,1′-hexamethylenebis[5-(p-chlorophenyl)-;2,4,11,13-Tetraazatetradecanediimidamide,N,N′′-bis(4-chlorophenyl)-3,12-diimino-;N1,N14-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide;1,6-Bis[5-(p-chlorophenyl)biguanidino]hexane;Chlorhexidine;Nolvasan;1,1′-Hexamethylenebis[5-(p-chlorophenyl)biguanide];Soretol;Chlorohex;Fimeil;Hexadol;Chlorohexidine;Tubulicid;1,6-Di(N-p-chlorophenylbiguanidino)hexane;Promax;Eburos;Hexident;Chlorhexamed forte;Consepsis;Dezin;Periogard;Dentosan;Chlorohexidene;Prevora;111883-36-4;328933-19-3;1520991-69-8
Categories:
Cosmetic Ingredient > Cosmetic Preservative

Description

Chlorhexidine is an antibacterial used as an antiseptic and for other applications.Target: AntibacterialChlorhexidine belongs to a group of medicines called antiseptic antibacterial agents. It is used to clean the skin after an injury, before surgery, or before an injection. Chlorhexidine is also used to clean the hands before a procedure. It works by killing or preventing the growth of bacteria on the skin.

Solid

Chlorhexidine Basic Attributes

Molecular Weight：

505.45

Exact Mass：

505.45

EC Number：

200-238-7

ATC Code：

D08AC02

HScode：

29215900

Characteristics

PSA：

178

XLogP3：

0.1

Appearance：

Solid

Density：

1.4±0.1 g/cm3

Melting Point：

134 °C

Flash Point：

311.6±32.9 °C

Refractive Index：

1.659

Water Solubility：

H2O: 0.08 g/100 mL (20 ºC)

Storage Conditions：

Store below +30°C.

Vapor Pressure：

1.98X10-14 mm Hg at 25 deg C (est)

Toxicity：

Oral-rat LD50: 9200 mg/kg;Oral-Mouse LDL0: 2515 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides, chloride fumes

PKA：

10.8(at 25 °C)

Collision Cross Section：

222.3 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|221.3 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

Ⅲ

Hazard category：

Transport codes：

UN 3077 9/PG 3

wgk germany：

hazard class code：

36/37/38-43-51/53-50/53

safety instructions：

26-36/37-60-61

RTECS Number：

DU1925000

Marks：

Xi,N

Storage features：

Warehouse ventilated, low temperature and dry

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P261-P273-P305 + P351 + P338-P342 + P311-P501

Hazard Statements：

H315-H319-H334-H335-H410

Toxicity

Toxicity class：

moderately toxic

Chlorhexidine Use and Manufacturing

Uses

Chlorhexidine is an antibacterial used for numerous applications. It is a cationic polybiguanide (bisbiguanide) used primarily as its salts, dihydrochloride, diacetate, and digluconate. Chlorhexidine is one of those drugs which are enlisted/included in the World Health Organization's List of Essential Medicines, a list of the most important drugs needed in a basic health system. Chlorhexidine is used as a germicidal compound in teat dips. Also used as navel treatment, udder and eye wash, surgical scrub and sterilization material. Chlorhexidine is used primarily as a topical antiseptic/disinfectant in wound healing, at catheterization sites, in various dental applications and in surgical scrubs. it is used as an antibacterial agent in humans to control gingivitis and over all plaque control in preventative dentistry. Hydrogenolysis of benzyl-nitrogen bonds. Bacteriostatic;Detergent.

Manufacturing Info：

2,4,11,13-Tetraazatetradecanediimidamide, N1,N14-bis(4-chlorophenyl)-3,12-diimino-: ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:505.4
XLogP3:0.1
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:13
Exact Mass:504.2031964
Monoisotopic Mass:504.2031964
Topological Polar Surface Area:178
Heavy Atom Count:34
Complexity:649
Undefined Bond Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Chlorhexidine is a broad-spectrum antiseptic and antimicrobial agent that is effective against a wide range of microorganisms including Gram-positive and Gram-negative bacteria, fungi, and yeasts. It works by disrupting the cell membrane of microbes, leading to cell death.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

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Registered Holders

RN LABORATORIES EUROPE BV

United States
Active
CADILA PHARMACEUTICALS LIMITED

India
Active
DISHMAN BIOTECH LIMITED

India
Active

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3697-42-5
Chlorhexidine gluconate Formula

18472-51-0
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Guide of Chlorhexidine

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
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