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Hexamethonium bromide

Hexamethonium bromide structure

CAS No:
55-97-0
Formula:
C12H30N2.2Br
Chemical Name:
Hexamethonium bromide
Synonyms:
1,6-Hexanediaminium,N1,N1,N1,N6,N6,N6-hexamethyl-,bromide (1:2);Ammonium,hexamethylenebis[trimethyl-,dibromide;1,6-Hexanediaminium,N,N,N,N′,N′,N′-hexamethyl-,dibromide;Hexamethylenebis[trimethylammonium bromide];C 6;Esametina;Gangliostat;Hexamethonium bromide;Hexamethonium dibromide;Hexameton;Hexonium dibromide;Simpatoblock;Vegolysen;Vegolysin;Methobromine;N,N,N,N′,N′,N′-Hexamethyl(hexamethylene)diammonium bromide;Hexamethylenebis(trimethylammonium) dibromide;1,6-Hexanebis(trimethylammonium) dibromide;Methobromin;Hexameton bromide;Bistrium bromide;Hexanium bromide;1,6-Bis(trimethylammonium)hexane dibromide;Hexane-1,6-bis(trimethylammonium bromide);Hexamethone bromide;41055-63-4
Categories:
Organic Chemistry > Amides

Description

Hexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.Target: nAChRHexamethonium is a non-depolarising ganglionic blocker, a nicotinic nACh receptor antagonist that acts in autonomic ganglia by binding mostly in or on the NN receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system but acts as antagonist at

A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.

Hexamethonium bromide Basic Attributes

Molecular Weight：

362.19

Exact Mass：

360.077545

EC Number：

200-249-7

UNII：

8J77X3S603

HScode：

29239000

Characteristics

PSA：

Appearance：

White Crystalline Powder and Agglomerates

Melting Point：

274-276 °C

Storage Conditions：

Desiccate at RT

Safety Information

Packing level：

Ⅲ

Transport codes：

2811

wgk germany：

hazard class code：

6.1

safety instructions：

22-24/25

RTECS Number：

BQ8575000

Precautionary statement(s)：

P260, P264, P270, P307+P311, P321, P405, P501

Hazard Statements：

H370

GHS Classification：

|Danger|H370 (100%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]|P260, P264, P270, P307+P311, P321, P405, and P501|Aggregated GHS information provided by 7 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses. (See all compounds classified as Nicotinic Antagonists.)|Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery. (See all compounds classified as Ganglionic Blockers.)

MeSH Entry Terms：

Bitartrate, Hexamethonium

Hexamethonium bromide Use and Manufacturing

Manufacturing Info：

1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide (1:2): ACTIVE|PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Computed Properties

Molecular Weight:362.19
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:362.07552
Monoisotopic Mass:360.07757
Heavy Atom Count:16
Complexity:121
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Material

Calcium hydroxide

Ethyl acetate

Ethanol

Trimethylamine

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