 Home > Encyclopedia > Physcion

Physcion

Physcion structure

CAS No:
521-61-9
Formula:
C16H12O5
Chemical Name:
Physcion
Synonyms:
9,10-Anthracenedione,1,8-dihydroxy-3-methoxy-6-methyl-;Anthraquinone,1,8-dihydroxy-3-methoxy-6-methyl-;Chrysophanic acid,6-methoxy-;1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthracenedione;Emodin 3-methyl ether;Parietin;Physcion;Rheochrysidin;1,8-Dihydroxy-3-methyl-6-methoxyanthraquinone;6-O-Methylemodin;NSC 251670;1,8-Dihydroxy-3-methoxy-6-methylanthraquinone;1,8-Dihydroxy-6-methoxy-3-methyl anthraquinone;Physcione;1,8-Dihydroxy-3-methoxy-6-methyl-9,10-anthraquinone;140670-52-6
Categories:
Agrochemicals > Biopesticides

Description

Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].

Physcion is a dihydroxyanthraquinone that is 9,10-anthraquinone bearing hydroxy substituents at positions 1 and 8, a methoxy group at position 3, and a methyl group at position 6. It has been widely isolated and characterised from both terrestrial and marine sources. It has a role as an apoptosis inducer, an antineoplastic agent, a hepatoprotective agent, an anti-inflammatory agent, an antibacterial agent, an antifungal agent and a metabolite. It derives from a 2-methylanthraquinone.

Physcion Basic Attributes

Molecular Weight：

284.26

Exact Mass：

284.26

EC Number：

208-315-7

UNII：

H6PT94IV61

NSC Number：

251670

DSSTox ID：

DTXSID20200101

HScode：

2914690090

Characteristics

PSA：

83.83000

XLogP3：

5.20

Appearance：

white powder

Density：

1.4±0.1 g/cm3

Melting Point：

207-208 °C

Boiling Point：

560.5±50.0 °C at 760 mmHg

Flash Point：

215.4±23.6 °C

Refractive Index：

1.678

Storage Conditions：

-20°C Freezer, Under Inert Atmosphere

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

RTECS Number：

CB6720000

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

Drug Information

MeSH Entry Terms：

emodin 3-methyl ether

Physcion Use and Manufacturing

A natural anthraquinone derivative, on the infection process of Blumeria graminis on wheat. Physcion is one of the important active ingredients of ethanol extract from the roots of Chinese rhubarb (Rheum officinale) for controlling powdery mildew.

Computed Properties

Molecular Weight:284.26
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:284.06847348
Monoisotopic Mass:284.06847348
Topological Polar Surface Area:83.8
Heavy Atom Count:21
Complexity:448
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Physcion

Shaanxi Cuikang Pharmaceutical Technolog Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Cosmetics raw materials,Pesticide intermediate,Photoelectric material,pharmaceutical intermediates,Raw materials for food and health products,Polymer materials,Fine Chemicals,Synthetic customization

Emodin-3-methyl ether

CAS No.: 521-61-9

Grade: Industrial Grade

Content: 99%

Inquiry
Wuhan Pnq Int Trade Co., Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Apigenin,PQQ,NMNH

PNQ Supply Emodin-3-Methyl Ether CAS 521-61-9

CAS No.: 521-61-9

Grade: Chemical Grade

Content: 99%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

Emodin-3-methyl ether 99% white powder kanbei

CAS No.: 521-61-9

Grade: Industrial Grade

Content: 99%

Inquiry
Hangzhou Weck Chemical Industry Co., Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Demulsifier Active Ingredient

High purity 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione

CAS No.: 521-61-9

Grade: Pharmaceutical Grade

Content: 99%

Inquiry
UMGS GROUP PTY LTD Contact Supplier

ZA
2 YRS

Business licensed

Distributor Supplier of Chemicals bulk

Physcion Natural Botanical Fungicide & Antimicrobial Compound

CAS No.: 521-61-9

Grade: Pharmaceutical Grade

Content: 98%

Inquiry