Orange I

350.32

350.033722

208-346-6

W9Q9OB858O

REDDISH-BROWN POWDER

2927000090

111

4.94570

260 °C (decomp)

SOL IN WATER TO ORANGE-RED SOLN, IN ALC TO ORANGE SOLN

LD50 intraperitoneal in rat: 1gm/kg

ACIDS PRECIPITATE THE AQ SOLN; SODIUM HYDROXIDE INTENSIFIES RED COLOR OF AQ SOLN|@ PH 7.6 COLOR IS BROWNISH-YELLOW; 8.9 PURPLE

NONH for all modes of transport

3

22-24/25

DB7085000

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Chung KT; Mutat Res 114 (3): 269-82 (1983). The significance of azo reduction in the mutagenesis and carcinogenesis of azo dyes is discussed.

C.I. Acid Orange 20's former production and use as a dye and indicator(1) may have resulted in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Due to the ionic nature of C.I. Acid Orange 20, the retention of the dye by ion-exchange processes(1,SRC) may slow down or prevent leaching depending on the soil type(SRC). As C.I. Acid Orange is an ionic compound, volatilization of this compound will not be important from moist soil surfaces(1,SRC). Based on limited pure culture data(2,3), C.I. Acid Orange 20 may biodegrade aerobically in soil(SRC).|AQUATIC FATE: C.I. Acid Orange 20 may be adsorbed by some sediments and particulate matter in water due to ion-exchange processes(1,SRC). As C.I. Acid Orange 20 is an ionic compound, volatilization from water surfaces is not expected(1,SRC). According to a classification scheme(2), an estimated BCF value of 0.5(3,SRC), from an estimated log Kow(4,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Based on limited pure culture data(5,6), C.I. Acid Orange 20 may biodegrade aerobically in water(SRC).|ATMOSPHERIC FATE: The ionic state of C.I. Acid Orange 20 makes this compound essentially non-volatile(1,SRC); therefore, this compound should exist in the particulate phase in the ambient atmosphere. Particulate-phase C.I. Acid Orange 20 may be physically removed from the air, mainly by wet deposition(SRC).

An estimated BCF value of 0.5 was calculated for C.I. Acid Orange 20(SRC), using an estimated log Kow of -0.14(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).

Due to the ionic nature of the dye, the retention of C.I. Acid Orange 20 by ion-exchange processes(1,SRC) may slow or prevent leaching of this compound depending on the soil type(SRC).

Since C.I. Acid Orange I is an ionic compound, volatilization from water and moist soil surfaces will not be important(1,SRC).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 896 workers are potentially exposed to C.I. Acid Orange 20 in the US(1). Occupational exposure may have been through inhalation of dust particles and dermal contact with this compound at workplaces where C.I. Acid Orange 20 was produced or used(2,SRC). The general population may be exposed to this compound by dermal contact with products containing C.I. Acid Orange 20(SRC).

LOW EXCRETION OF ORANGE I IN ANIMALS NOT SHOWING DIARRHEA IS DUE TO ITS DEGRADATION BY INTESTINAL FLORA...RATHER THAN TO ITS ABSORPTION THROUGH INTESTINAL WALL. ORAL ADMIN OF 100 MG TO DOG WITH BILE FISTULA RESULTS IN RECOVERY OF ONLY 0.4% IN BILE, COMPARED TO 47% RECOVERY AFTER ITS SC ADMIN.

URINE OF DOG GIVEN 5 G ORANGE I CONTAINED A LITTLE OF UNCHANGED COLOR TOGETHER WITH SULFANILIC ACID AND 4-AMINO-1-NAPHTHOL AFTER 48 HR.

SINGLE DOSES OF 80 MG ORANGE I PRODUCED DIARRHEA (CATHARSIS) IN 4-8 HR IN SEVERAL VOLUNTEERS.

Benzenesulfonic acid, 4-[2-(4-hydroxy-1-naphthalenyl)diazenyl]-, sodium salt (1:1): ACTIVE|...USED FOR DYEING TEXTILES & LEATHER AND AS INDICATOR. IT WAS ONE OF 7 ORIGINAL COLORS PERMITTED UNDER US PURE FOOD & DRUGS ACT OF 1906... IT WAS REMOVED FROM APPROVED LIST FOR FOOD USE IN US IN 1956, BUT WAS PERMITTED IN EXTERNALLY APPLIED DRUGS & COSMETICS; HOWEVER, IN 1968, APPROVAL...WAS...DISCONTINUED...|Specifications for CI Acid Orange 20 given by FAO/WHO (1966) and by the Japan Food Hygiene Association (1974) require that the product contain a minimum of 85% pure color. Specifications given for a color reference standard require that it contain a minimum of 96.5% pure color.

Food Additives -> COLOUR; -> JECFA Functional Classes

Food Additives -> COLOUR;