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Puromycin hydrochloride

Puromycin hydrochloride structure

CAS No:
58-58-2
Formula:
C22H29N7O5.2ClH
Chemical Name:
Puromycin hydrochloride
Synonyms:
Adenosine,3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-,hydrochloride (1:2);Adenosine,3′-(α-amino-p-methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyl-,dihydrochloride,L-;Adenosine,3′-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-,dihydrochloride,(S)-;Adenosine,3′-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyl-,dihydrochloride;CL 16,536;3′-(L-α-Amino-p-methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyladenosine dihydrochloride;PDH;Puromycin dihydrochloride;Puromycin hydrochloride;Stylomycin dihydrochloride;CL 13900 dihydrochloride;P 638 dihydrochloride;CL 16536;NSC 3055
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Puromycin dihydrochloride is the dihydrochloride salt of puromycin. Puromycin is an aminoglycoside antibiotic that inhibits protein synthesis.

Puromycin dihydrochloride is a white powder. (NTP, 1992)

Puromycin dihydrochloride is a white powder. (NTP, 1992)|Puromycin is an aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome. It has a role as a nucleoside antibiotic, an antiinfective agent, an antineoplastic agent, a protein synthesis inhibitor, an antimicrobial agent, an EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor and an EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor. It is a conjugate base of a puromycin(1+).|Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting in significant cell death at appropriate doses.|Puromycin is an aminoglycoside antibiotic isolated from the bacterium Streptomyces alboniger. Acting as an analog of the 3' terminal end of aminoacyl-tRNA, puromycin incorporates itself into a growing polypeptide chain and causes its premature termination, thereby inhibiting protein synthesis. This agent has antimicrobial, antitrypanosomal, and antineoplastic properties; it is used as an antibiotic in cell culture. (NCI04)|A cinnamamido ADENOSINE found in STREPTOMYCES alboniger. It inhibits protein synthesis by binding to RNA. It is an antineoplastic and antitrypanosomal agent and is used in research as an inhibitor of protein synthesis.

Puromycin hydrochloride Basic Attributes

Molecular Weight：

544.43

Exact Mass：

471.223017

EC Number：

200-387-8

UNII：

4A6ZS6Q2CL

DSSTox ID：

DTXSID8036788|DTXSID7045861

NCI Thesaurus Code：

C787

HScode：

29419090

Characteristics

PSA：

160.88000

XLogP3：

0.93

Appearance：

Puromycin dihydrochloride is a white powder. (NTP, 1992)

Density：

1.5±0.1 g/cm3

Melting Point：

168-170℃

Refractive Index：

1.701

Water Solubility：

H2O: soluble 50mg/mL (Sterilize stock solution by filtration using 0.22 μm filter then store in aliquots at20 °C.)

Storage Conditions：

−20°C

Toxicity：

LD50 oral in guinea pig: 600mg/kg

Air and Water Reactions：

Water soluble.

Reactive Group：

Alcohols and Polyols

Reactivity Profile：

PUROMYCIN DIHYDROCHLORIDE is sensitive to prolonged exposure to heat. (NTP, 1992). Behaves as a very weak acid in solution.

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

22-40

safety instructions：

24/25

RTECS Number：

AU7355000

Marks：

Stability/Shelf Life：

Stable. Heat sensitive. Incompatible with strong oxidizing agents.

Hazard Statements：

H302

Fire Hazards：

Flash point data for this chemical are not available, but it is probably combustible. (NTP, 1992)

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 50 companies from 1 notifications to the ECHA C&L Inventory.

Fire Fighting：

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Nonfire Spill Response：

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this material under freezer conditions. (NTP, 1992)

Personal Protective Equipment：

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Drug Information

MeSH：

Antimetabolites that are useful in cancer chemotherapy. (See all compounds classified as Antimetabolites, Antineoplastic.)|Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)|Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA. (See all compounds classified as Trypanocidal Agents.)

First Aid：

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

MeSH Entry Terms：

CL 13900

Puromycin hydrochloride Use and Manufacturing

Research tool for studying protein synthesis; cell line selection agent in gene transfer experiments.

Computed Properties

Molecular Weight:471.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:8
Exact Mass:471.22301705
Monoisotopic Mass:471.22301705
Topological Polar Surface Area:161
Heavy Atom Count:34
Complexity:680
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Puromycin dihydrochloride

CAS No.: 58-58-2

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Puromycin Dihydrochloride

CAS No.: 58-58-2

Content: 98%

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