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D-α-Tocopherol

D-α-Tocopherol structure

CAS No:
59-02-9
Formula:
C29H50O2
Chemical Name:
D-α-Tocopherol
Synonyms:
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4R,8R)-4,8,12-trimethyltridecyl-, (2R)-;covirel;E-vitamin succinate;Pheryl-E;Vita plus E;(+)-ALPHA-TOCOPHEROL TYPE V;D-PROFECUNDIN;D-PHYTOGERMINE
Categories:
Food Additives > Food Antioxidants

Description

(+)-α-Tocopherol is a vitamin E derivative. vitamin E is a fat-soluble antioxidant.

α-Tocopherol (phenyl-5,7-dimethyl-d6) is the most bioactive form of fat-soluble vitamin E, which has a stable deuterium label, can be used as an internal standard for chromatographic methods with a tandem mass spectrometric detector.

light yellow liquid

VITAMIN E is sometimes referred to as the antisterility vitamin, factor X (an earlier designation), chemically vitamin E is alphatocopherol. Active analogues and related compounds include: dl-α-Tocopherol; 1-α-tocopherol; esters (succinate, acetate, phosphate), and β, ζ 1, ζ 2- tocopherols. The principal physiological forms are D-a-tocopherol, tocopheronolactone, and their phosphate esters.

ChEBI: An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.

D-α-Tocopherol Basic Attributes

Molecular Weight：

430.71

Exact Mass：

430.71

BRN：

4712525

EC Number：

200-412-2

TSCA：

TSCA listed

Color/Form：

clear yellow

HScode：

29362800

Characteristics

PSA：

29.46000

XLogP3：

10.7

Appearance：

clear yellow oil

Density：

0.95 g/mL at 25 °C(lit.)

Melting Point：

2.5-3.5 °C

Boiling Point：

200-220 °C0.1 mm Hg(lit.)

Flash Point：

253 °C

Refractive Index：

n20/D1.505(lit.)

Water Solubility：

INSOLUBLE

Storage Conditions：

2-8°C

Vapor Pressure：

1.4X10-8 mm Hg at 25 deg C (est)

Specific rotation：

24 º (c=2, in isooctane 25 ºC)

Odor：

lt. yel. to red visc. oil, nearly odorless

Taste：

Little or no taste

PKA：

11.40±0.40(Predicted)

Critical Temperature & Pressure：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

23-24/25-37/39-26

RTECS Number：

DJ2900000

Marks：

Stability/Shelf Life：

Stable. Combustible. May be sensitive to light and air. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P261, P272, P280, P302+P352, P321, P333+P313, P363, P501

Hazard Statements：

36/37/38

Drug Information

Health Hazards：

The physiological functions of vitamin E substances include: (1) bio logical antioxidant; (2) normal growth maintenance; (3) protects unsaturated fatty acids and membrane structures; (4) aids intestinal absorption of unsaturated fatty acids; (5) maintains normal muscle metabolism; (6) maintains integrity of vascular system and central nervous system; (7) detoxifying agent; and (8) maintains kidney tubules, lungs, genital structures, liver, and red blood cell membranes.In livestock and laboratory animals, a deficiency of vitamin E substances may cause degeneration of reproductive tissues, muscular dystrophy, encephalomalacia, and liver necrosis. Considerable research is required to fully determine supplementation of livestock diets unless typical symptoms of a deficiency appear. Symptoms have appeared where there are selenium deficiencies in the soil and where there are excessive levels of nitrates in the soil. “White muscle” is the term used to describe a condition of muscular dystrophy in cattle.

D-α-Tocopherol Use and Manufacturing

α-Tocopherol is the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils.

vitamin E, antioxidant

Use in insect cell culture applications as an antioxidant.

Computed Properties

Molecular Weight:430.7
XLogP3:10.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:12
Exact Mass:430.381080833
Monoisotopic Mass:430.381080833
Topological Polar Surface Area:29.5
Heavy Atom Count:31
Complexity:503
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Diethyl carbonate

1-Butanol

Methyl ethyl ketone

Downstream Products

2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, 6-acetate

Price Analysis

Make your D-α-Tocopherol purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on D-α-Tocopherol prices .

Drug Function and Efficacy

Extract the name, type (main ingredient or excipient), content, unit, and pharmacological action of the raw material from the above information

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

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Specifications	0.5g/tablet

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Registered Holders

ARCHER DANIELS MIDLAND COMPANY

European Union
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