Glycylglycine
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Glycylglycine
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CAS No:
556-50-3
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Formula:
C4H8N2O3
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Chemical Name:
Glycylglycine
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Synonyms:
Glycine,glycyl-;Glycine,N-glycyl-;Glycylglycine;N-Glycylglycine;Diglycine;α-Glycylglycine;Glycine dipeptide;Glycine-glycine;Gly2;2-(Aminoacetamido)acetic acid;Diglycocoll;NSC 49346;1: PN: WO2014159931 PAGE: 58 claimed sequence;36: PN: WO2010076654 SEQID: 36 claimed sequence;4: PN: WO2017095140 PAGE: 4 claimed sequence;2: PN: CN107034198 PAGE: 2 claimed sequence;9: PN: CN107098974 PAGE: 2 claimed sequence;13: PN: WO2017167712 SEQID: 23 claimed protein;7: PN: WO2018022936 SEQID: 142 claimed sequence;G 0124;1: PN: WO2018071767 PAGE: 80 claimed sequence;1: PN: WO2018075564 PAGE: 122 claimed sequence;4: PN: WO2018201047 SEQID: 102 claimed protein;89: PN: WO2019035010 SEQID: 89 claimed protein;38: PN: WO2020048525 SEQID: 46 claimed protein;29: PN: US20200095309 SEQID: 56 claimed protein;2-(2-Aminoacetamido)acetic acid;2-[(2-Aminoacetyl)amino]acetic acid;2: PN: WO2020191289 PAGE: 118 claimed sequence;16: PN: WO2021041934 SEQID: 69 claimed protein;61499-00-1
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CAS No:
Description
Glycylglycine is the simplest of all peptides and could function as a gamma-glutamyl acceptor.
Solid
Glycylglycine is a dipeptide formed from glycine residues. It has a role as a human metabolite. It derives from a glycine. It is a tautomer of a glycylglycine zwitterion.|The simplest of all peptides. It functions as a gamma-glutamyl acceptor.
Characteristics
92.42000
-2.9
Solid
1.554 g/cm3 @ Temp: -5 °C
215 °C (decomp)
453.2ºC at 760 mmHg
227.9ºC
1.505
soluble in hot water:166 mg/mL at 21 °C
-15ºC
Safety Information
NONH for all modes of transport
3
R36
S24/25
Xi
Stable. Incompatible with strong oxidizing agents.
P305 + P351 + P338
H319
|Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 66 companies from 4 notifications to the ECHA C&L Inventory.
Glycylglycine Use and Manufacturing
Glycylglycine is the dipeptide of glycine, making it the simplest peptide. The compound was first synthesized by Emil Fischer and Ernest Fourneau in 1901 by boiling 2,5-diketopiperazine (glycine anhydride) with hydrochloric acid. Shaking with alkali and other synthesis methods have been reported.Because of its low toxicity, it is useful as a buffer for biological systems with effective ranges between pH 2.5-3.8 and 7.5-8.9, however, it is only moderately stable for storage once dissolved. It is used in the synthesis of more complex peptides.Glycylglycine has also been reported to be helpful in solubilizing recombinant proteins in E. coli. Using different concentrations of the glycylglycine improvement in protein solubility after cell lysis has been observed.
Glycine, glycyl-: ACTIVE
Cosmetics -> Hair conditioning; Skin conditioning
Computed Properties
Molecular Weight:132.12
XLogP3:-2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:132.05349212
Monoisotopic Mass:132.05349212
Topological Polar Surface Area:92.4
Heavy Atom Count:9
Complexity:123
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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