2-Methylbenzenethiol

124.2

124.20

774068

205-276-8

6FU2EGI4VS

80655

DTXSID8047135

29309070

1

2.98

Clear colorless to pale yellow Liquid

1.041 g/cm³ @ Temp: 20 °C

15 °C

195 °C

147 °F

n 20/D 1.578(lit.)

H2O: insoluble ;Sol in alcohol, ether; insol in water

Store below +30°C.

0.816 mm Hg at 25 deg C

Abdominal cavity-mouse LD50: 100 mg/kg

Flammable; emit toxic sulfur oxide gas when burning

1.1%(V)

pKa= 6.64 @ 26 °C

When heated to decomp it emits toxic fumes of SOx.

Flammable liquid.

III

6.1

2810

3

37/38-41-36/37/38-20/21/22

26-39-36/37/39-23

XT8750000

Xi,Xn

The warehouse is ventilated, low-temperature and dry; stored separately from oxidants.

Harmful/Irritant/Stench

Corrosive to skin and cornea

Stable under normal temperatures and pressures.

P261-P280-P305 + P351 + P338

H315-H318-H335

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

|Danger|H302 (97.11%): Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P280, P301+P312, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P330, P363, P405, and P501|Aggregated GHS information provided by 1451 companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

highly toxic

LD50 Mouse ip 100 mg/kg

2-Thiocresol's possible production as an antiseptic(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 440(SRC), determined from a structure estimation method(2), indicates that 2-thiocresol is expected to have moderate mobility in soil(SRC). The pKa of 2-thiocresol is 6.64(3) indicating that the anionic form of 2-thiocresol will exist in slightly acidic to basic soils and anions are expected to have higher mobility than the neutral species(SRC). Volatilization of 2-thiocresol from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.6X10-4 atm-cu m/mole(SRC), using a fragment constant estimation method(4). However, 2-thiocresol in the anionic form will not volatilize. 2-Thiocresol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.816 mm Hg(5).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 440(SRC), determined from an estimation method(2), indicates that 2-thiocresol is expected to slightly adsorb to suspended solids and sediment(SRC). Volatilization of the neutral species from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.6X10-4 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 3 hrs and 5.2 days, respectively(SRC). A pKa of 6.64(5) indicates that the anionic form of 2-thiocresol will exist in slightly acidic to basic waters and the anionic form will not volatilize from water(SRC). According to a classification scheme(6), an estimated BCF of 62(SRC), from an estimated log Kow of 3.2(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is moderate.|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-thiocresol, which has a vapor pressure of 0.816 mm Hg at 25 °C(2), is expected to exist solely in the vapor-phase in the ambient atmosphere. Vapor- phase 2-thiocresol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 27 hrs(SRC), calculated from its rate constant of 1.4X10-11 cu cm/molecule-sec at 25 °C(SRC) determined using a structure estimation method(3). Although thiocresols may be susceptible to photolysis, sufficient experimental data are not available to predict the relative importance of their photolysis in the environment(SRC).

The rate constant for the vapor-phase reaction of 2-thiocresol with photochemically-produced hydroxyl radicals has been estimated as 1.4X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half- life of about 27 hrs at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2-Thiocresol is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2). Although thiocresols may be susceptible to photolysis, sufficient experimental data are not available to predict the relative importance of their photolysis in the environment(SRC).

An estimated BCF of 62 was calculated for 2-thiocresol(SRC), using an estimated log Kow of 3.2(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate.

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 2-thiocresol can be estimated to be 440(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-thiocresol is expected to have moderate mobility in soil. The pKa of 2-thiocresol is 6.64(3) indicating that the anionic form of 2-thiocresol will exist in slightly acidic to basic soils and anions are expected to have higher mobility than the neutral species(SRC). Volatilization from moist soil surfaces is not expected to be an important fate process for the anionic species.

The Henry's Law constant for 2-thiocresol is estimated as 3.6X10-4 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 2-thiocresol is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life of the neutral species from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 3 hrs(SRC). The volatilization half-life of the neutral species from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 5.2 days(SRC). A pKa of 6.64(3) for 2-thiocresol indicates that the anionic form of 2-thiocresol will exist in slightly acidic to basic waters and the anionic form is not expected to volatilize from water(SRC). 2-Thiocresol's Henry's Law constant(1) indicates that volatilization of the neutral species from moist soil surfaces may occur(SRC). However, 2-thiocresol in the anionic form is not expected to volatilize. 2-Thiocresol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.816 mm Hg(4).

Occupational exposure to 2-thiocresol may occur through inhalation and dermal contact with this compound at workplaces where 2-thiocresol is produced. (SRC)

ANTISEPTIC; DERMATOLOGIC AGENT (UNSPECIFIED ISOMER)-NO EVIDENCE OF CURRENT USE

Benzenethiol, 2-methyl-: ACTIVE

Analyte: Cresol isomers; Matrix: air; Procedure: Gas chromatography, flame ionization detector; Desorption: 1 ml acetone, stand 30 min; Range: 0.1-1.2/ samp; Precision: 0.028; Interferences: high humidity /Cresol, all isomers/

Analyte: Phenol and p-cresol; Matrix: urine; Procedure: Gas chromatography, flame ionization detector; Treatment: acid hydrolysis, extraction; Range: 2-300 ug phenol/ml urine, 2-500 ug p-cresol/ml urine; Controls: pooled urine from unexposed workers; Est LOD: 0.5 ug/ml urine; Recovery: 94% @ 15 ug phenol/ml urine, 95% @ 50 ug p-cresol/ml urine; Precision: 0.128, 0.091; Interferences: o-phenylphenol has GC retention times similar to phenol /Phenol and p-cresol in urine/

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