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3-Methyl-2-pyridone

3-Methyl-2-pyridone structure

CAS No:
1003-56-1
Formula:
C6H7NO
Chemical Name:
3-Methyl-2-pyridone
Synonyms:
2(1H)-Pyridone, 3-methyl-;3-Methyl-2-pyridinol;AKOS BBS-00002968;3-METHYL-2-PYRIDINONE;3-METHYL-2-PYRIDONE;3-METHYL-1,2-DIHYDROPYRIDIN-2-ONE;2-HYDROXY-3-METHYLPYRIDINE 97%;2-Hydroxy-3-Piocoline
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

Light yellow needles

ChEBI: 3-Methyl-1,2-dihydropyridin-2-one is a member of methylpyridines.

3-Methyl-2-pyridone Basic Attributes

Molecular Weight：

109.13

Exact Mass：

109.13

BRN：

1422044

EC Number：

213-710-2

UNII：

VM19FN4HHV

NSC Number：

4343

DSSTox ID：

DTXSID50143118

Color/Form：

White to Orange to Green

HScode：

29333995

Characteristics

PSA：

29.1

XLogP3：

0.6

Density：

1.1143 (rough estimate)

Melting Point：

139-141 °C

Boiling Point：

204.59°C (rough estimate)

Flash Point：

172.7ºC

Refractive Index：

1.5444 (estimate)

Water Solubility：

Soluble in methanol.

PKA：

12.61±0.10(Predicted)

Critical Temperature & Pressure：

Sealed in dry,Room Temperature

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

Xn,Xi

safety instructions：

36/37/39-26-22-36

Marks：

Xn,Xi

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

36/37/38-20/21/22-41-37/38-22

GHS Classification：

|Danger|H302 (97.73%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

3-methyl-2-pyridone

3-Methyl-2-pyridone Use and Manufacturing

Methods of Manufacturing

General procedure: In a dry Schlenk tube 2-bromo-6-methylpyridine (5.98 g, 35.0 mmol) was dissolved in 100 mL oft-AmylOH and KOt-Bu (39.3 g , 350.0 mmol) was added. The mixture was stirred at 100 °C for 40 h. The solvent was removed under reduced pressure and the residue was dissolved in 50 mL of HCOWas added to the reactorPyridine-2-one 19-1 (0.095 g, 1 mmol)Dicumyl peroxide (0.81 g, 3 mmol) and 2 ml of acetic acid, 120 ° C reaction, TLC followed the reaction until complete.The crude product obtained after the completion of the reaction was purified by column chromatography (petroleum ether: ethyl acetate = 1: 1)Separation and purification to give the target product 19-2 (yield 85percent).Diisopropyl azodicarboxylate (1.02 g, 5.04 mmol) was added slowly to a solution of

Uses

3-Methyl-2-pyridone, is used as a reactant with chloro-methoxy-methane to produce 1-methoxymethyl-3-methyl-1H-pyridin-2-one. This reaction will need reagent solvent CH2Cl2. The reaction time is 24 hours with ambient temperature

Computed Properties

Molecular Weight:109.13
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:109.052763847
Monoisotopic Mass:109.052763847
Topological Polar Surface Area:29.1
Heavy Atom Count:8
Complexity:167
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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3-Methyl-2-pyridone

CAS No.: 1003-56-1

Content: 99.00%

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CN
4 YRS

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3-Methyl-2-pyridone Manufacturer/High quality/Best price/In stock

CAS No.: 1003-56-1

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