Colistin

1155.455

1154.75000

213-907-3

DTXSID1040663

J01XB01|A - Alimentary tract and metabolism|J - Antiinfectives for systemic use

491

-2.4

Solid

1.1050 (rough estimate)

200-220 °C

807.67°C (rough estimate)

883.3ºC

1.6700 (estimate)

2.38e-01 g/L

RECONSTITUTED INJECTIONS SHOULD BE STORED @ 2-8 or 15-30 DEG C & MUST BE USED WITHIN 7 DAYS. /COLY-MYCIN M IM/

III

6.1(b)

3249

RECONSTITUTED ORAL SUSPENSIONS CONTAINING COLISTIN SULFATE ARE STABLE 2 WK IF STORED BETWEEN 2-15 DEG C. /COLISTIN SULFATE/

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

COLISTIMETHATE...MAY INTERACT...WITH CARBENICILLIN. /COLISTIMETHATE/|COLISTIN METHANESULFONATE REDUCED BY MORE THAN 20% THE AMT OF URINARY SALICYLAMIDE GLUCURONIDE FORMED IN CHILDREN FROM 20 MG/KG DOSE SALICYLAMIDE. /COLISTIN METHANESULFONATE/|Since nephrotoxic and/or neurotoxic effects may be additive, concurrent or sequential use of colistimethate sodium and other drugs with similar toxic potentials (e.g., aminoglycosides, amphotericin B, capreomycin, methoxyflurane, polymyxin B sulfate, vancomycin) should be avoided, if possible. /Colistimethate sodium/

Colobreathe is indicated for the management of chronic pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis (CF) aged six years and older.Consideration should be given to official guidance on the appropriate use of antibacterial agents.

Antibiotics, Peptide|THERAPEUTIC INDICATIONS FOR COLISTIN ARE ESSENTIALLY SAME AS THOSE FOR POLYMYXIN B. INFECTIONS OF CERTAIN TYPES CAUSED BY PSEUD AERUGINOSA ARE ESPECIALLY SUSCEPTIBLE.|PRIMARY USE OF POLYMYXIN B IS FOR TREATMENT OF INFECTIONS CAUSED BY GRAM-NEGATIVE BACTERIA, ESPECIALLY PSEUDOMONAS. ...IS EFFECTIVE IN TREATMENT OF URINARY TRACT INFECTIONS CAUSED BY PSEUDOMONAS OR OTHER GRAM-NEGATIVE BACILLI RESISTANT TO OTHER ANTIMICROBIAL AGENTS... /POLYMYXIN B/|/POLYMYXIN B & COLISTIMETHATE SODIUM/...RECOMMENDED FOR TREATING PERITONITIS & PNEUMONIA, BUT SOME AUTHORITIES QUESTION THEIR EFFECTIVENESS FOR THESE PURPOSES. /COLISTIMETHATE SODIUM/|For more Therapeutic Uses (Complete) data for COLISTIN (11 total), please visit the HSDB record page.

ADVERSE REACTIONS TO COLISTIMETHATE HAVE BEEN NOTED IN 20% OF PT GIVEN THE DRUG; THEY ARE GENERALLY REVERSIBLE... /COLISTIMETHATE/|COLISTIMETHATE SODIUM SHOULD NOT BE ADMIN INTRATHECALLY. /COLISTIMETHATE SODIUM/|...NOT INDICATED FOR INFECTIONS CAUSED BY PROTEUS OR NEISSERIA SPECIES. /SODIUM COLISTIMETHATE/|POSSIBLE EMBRYOTOXIC & TERATOGENIC EFFECTS HAVE BEEN REPORTED WHEN COLISTIMETHATE SODIUM WAS ADMINISTERED TO PREGNANT RABBITS. /NA COLISTIMETHATE/|For more Drug Warnings (Complete) data for COLISTIN (13 total), please visit the HSDB record page.

RESISTANCE TO COLISTIN HAS BEEN INDUCED IN VITRO... BUT MAY BE REVERSIBLE WHEN ANTIBIOTIC IS WITHDRAWN. DEVELOPMENT OF RESISTANCE DURING THERAPY...ONLY RARELY. COMPLETE CROSS-RESISTANCE OCCURS BETWEEN COLISTIN AND POLYMYXIN B...

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

/COLISTIMETHATE SODIUM/...IS EXCRETED IN DOG URINE TO MUCH GREATER EXTENT THAN SIMPLE SULFATE FORM, & THEORETICALLY SHOULD BE BETTER IN URINARY INFECTIONS.|DRUG PASSES FROM MATERNAL TO FETAL CIRCULATION. PREMATURE INFANTS INJECTED WITH 1 MG/KG DO NOT DEVELOP EFFECTIVE PLASMA CONCN OF ANTIBIOTIC; WITH DOSE OF 2 MG/KG, PEAK VALUE OF ABOUT 5 UG/ML IS REACHED IN 30 MIN. /COLISTIMETHATE/|PLASMA CONCN ARE HIGHER IN PERSONS WITH RENAL INSUFFICIENCY & ARE RELATED TO DEGREE OF RENAL DYSFUNCTION. COLISTIMETHATE IS EXCRETED MAINLY BY GLOMERULAR FILTRATION. URINE CONCN EXCEED 200 UG/ML DURING FIRST 2 HR AFTER USUAL IM DOSE. /COLISTIMETHATE/|DRUG IS EXCRETED MORE RAPIDLY IN CHILDREN THAN IN ADULTS. COLISTIMETHATE DOES NOT GAIN ACCESS TO CEREBROSPINAL FLUID, EVEN WHEN MENINGES ARE INFLAMED. /COLISTIMETHATE/|For more Absorption, Distribution and Excretion (Complete) data for COLISTIN (8 total), please visit the HSDB record page.

...hydrolyzed in vivo to colistin and possibly other metabolites with fewer substituted amino groups...|AFTER IV INJECTION RABBITS, 75% DOSE EXCRETED IN URINE UNCHANGED. SMALL AMT FOUND IN BILE. COLISTIN-N-GLUCURONIDE FOUND IN URINE (1.7% OF DOSE) & BILE (6.7% OF DOSE). /SODIUM COLISTIN METHANE SULFONATE/

IM INJECTION OF 150 MG OF COLISTIMETHATE IN ADULTS PRODUCE PEAK PLASMA CONCN OF 6 UG/ML @ 2 HR; THIS DECLINES WITH HALF-TIME OF 2 HR. SAME QUANTITY GIVEN IV YIELDS MAXIMAL PLASMA CONCN OF 18 UG/ML; THIS FALLS TO ABOUT 0.4 UG/ML @ 12 HR. /COLISTIMETHATE/

POLYMYXIN B IS SURFACE-ACTIVE AGENT... CONTAINING LIPOPHILIC & LIPOPHOBIC GROUPS SEPARATED WITHIN MOLECULE. /POLYMYXIN B/|PERMEABILITY OF THE BACTERIAL MEMBRANE CHANGES IMMEDIATELY ON CONTACT WITH DRUG. SENSITIVITY TO POLYMYXIN B APPARENTLY IS RELATED TO THE PHOSPHOLIPID CONTENT OF THE CELL WALL-MEMBRANE COMPLEX. /POLYMYXIN B/|Colistin acts like a cationic detergent and binds to and damages the bacterial cytoplasmic membrane of susceptible bacteria. Damage to the bacterial cytoplasmic membrane alters the osmotic barrier of the membrane and causes leakage of essential intracellular metabolites and nucleosides.

COLISTIMETHATE SODIUM MAY ADVERSELY AFFECT KIDNEYS & NERVOUS SYSTEM. ELEVATED BLOOD UREA NITROGEN LEVELS, USUALLY REVERSIBLE, HAVE BEEN REPORTED IN A FEW INFANTS & ADULTS. SYMPTOMS OF UREMIA & ACUTE RENAL FAILURE AS RESULT OF OVERODSAGE IN PT WITH IMPAIRED RENAL FUNCTION...OBSERVED. /COLISTIMETHATE SODIUM/|PAIN CAN OCCUR @ SITE OF INJECTION. ADVERSE RENAL EFFECTS APPEAR TO BE LESS COMMON THAN WITH POLYMYXIN B, BUT MARKED AZOTEMIA MAY OCCASIONALLY DEVELOP AFTER LARGE DOSES IN PT WITH LOW RENAL RESERVE. ACUTE TUBULAR NECROSIS HAS BEEN OBSERVED IN ABOUT 2% OF PT GIVEN COLISTIMETHATE; IT IS USUALLY REVERSIBLE. /COLISTIMETHATE/|Poison by subcutaneous, intravenous and intraperitoneal routes.

Colimycin

COLISTIMETHATE SODIUM, USP (COLY-MYCIN M PARENTERAL), IS MARKETED FOR IV OR IM INJECTION IN VIALS CONTAINING EQUIV OF 20 OR 150 MG OF COLISTIN BASE TO BE RECONSTITUTED TO CONTAIN 10 OR 75 MG/ML, RESPECTIVELY. /COLISTIMETHATE SODIUM/|COLISTIN SULFATE FOR ORAL SUSPENSION, USP (COLY-MYCIN S ORAL SUSPENSION) MARKETED AS POWDER (300 MG) TO BE SUSPENDED IN DISTILLED WATER PRIOR TO DISPENSING (5 MG/ML). /COLISTIN SULFATE/|COLISTIN IS AVAILABLE FOR CLINICAL USE AS COLISTIN SULFATE, FOR ORAL USE, & COLISTIMETHATE SODIUM (COLISTIN SODIUM METHANESULFONATE), A PARENTERAL PREPN.|Composed of colistins A, B, and C.

COLISTIN IS IDENTICAL TO POLYMYXIN B EXCEPT FOR SUBSTITUTION OF RESIDUE OF D-LEUCINE FOR THAT OF D-PHENYLALANINE.|VET APPLICATIONS: IN CALF SCOURS; IN RESP & UROGENITAL INFECTIONS IN CATS & DOGS, & ESPECIALLY PSEUDOMONAS AEROGINOSA INFECTIONS. OFTEN USED WITH CHLORAMPHENICOL. SYNERGISTIC WITH TRIMETHOPRIM.|WARNING: IN FRANCE, RUSSIA, & SOME RUSSIAN SATELLITE COUNTRIES THE WORD "COLLMYCIN" FREQUENTLY REFERS TO ANTIBIOTIC NEOMYCIN & NOT COLISTIN. ELSEWHERE, COLIMYCIN IS COLISTIN. ... AN INJECTABLE FORM, SODIUM COLISTIMETHANESULFONATE, IS KNOWN BY GENERIC NAME COLISTIMETHATE SODIUM.|SEPARATION INTO POLYMYXINS E1 & E2 & IDENTITY OF COLISTIN A WITH POLYMYXIN E1: WILKINSON, LOWE, J CHEM SOC 1964, 4107. SYNTHESIS COLISTIN A: STUDER ET AL, HELV CHIM ACTA 48, 1371 (1965).|For more General Manufacturing Information (Complete) data for COLISTIN (6 total), please visit the HSDB record page.

TLC DIFFERENTIATION OF POLYMYXINS INCL COLISTIN.

Human drugs -> Colobreathe -> EMA Drug Category|Antibacterials for systemic use -> Human pharmacotherapeutic group|Veterinary Drug -> ANTIMICROBIAL_AGENT; -> JECFA Functional Classes

Veterinary Drug -> ANTIMICROBIAL_AGENT;