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7,8-Dihydroneopterin

7,8-Dihydroneopterin structure

CAS No:
1218-98-0
Formula:
C9H13N5O4
Chemical Name:
7,8-Dihydroneopterin
Synonyms:
4(3H)-Pteridinone,2-amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-;1,2,3-Propanetriol,1-(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-,D-erythro-;4(1H)-Pteridinone,2-amino-7,8-dihydro-6-(1,2,3-trihydroxypropyl)-,[S-(R*,S*)]-;4(1H)-Pteridinone,2-amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-;2-Amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone;2-Amino-4-hydroxy-6-(D-erythro-1′,2′,3′-trihydroxypropyl)-7,8-dihydropteridine;7,8-Dihydroneopterin;Dihydroneopterin;Neopterin,dihydro-;D-erythro-7,8-Dihydroneopterin;7,8-Dihydro-D-neopterin;7,8-Dihydro-D-erythro-neopterin;2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine;26955-65-7;87612-11-1
Categories:
Dyes and Pigments > Pigment

Description

7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1].

Solid

7,8-dihydroneopterin is a neopterin where positions C-7 and C-8 have been hydrogenated. It has a role as a metabolite, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a dihydropterin and a member of neopterins.

7,8-Dihydroneopterin Basic Attributes

Molecular Weight：

255.23

Exact Mass：

255.23

DSSTox ID：

DTXSID00153368

Characteristics

PSA：

156.85000

Appearance：

Solid

Density：

2.03g/cm3

Boiling Point：

614.6ºC at 760mmHg

Flash Point：

325.5ºC

Refractive Index：

1.86

Safety Information

wgk germany：

hazard class code：

R36/37/38

safety instructions：

26-36

Marks：

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

7,8-dihydro-neopterin

7,8-Dihydroneopterin Use and Manufacturing

Dihydroneopterin is an impurity of Neopterin (N390005), a precursor in the biosynthesis of Biopterin (B389020).

Computed Properties

Molecular Weight:255.23
XLogP3:-3.3
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:3
Exact Mass:255.09675391
Monoisotopic Mass:255.09675391
Topological Polar Surface Area:153
Heavy Atom Count:18
Complexity:470
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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7,8-Dihydro-D-Neopterin

CAS No.: 1218-98-0

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