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Pyritinol

Pyritinol structure

CAS No:
1098-97-1
Formula:
C16H20N2O4S2
Chemical Name:
Pyritinol
Synonyms:
4-Pyridinemethanol,3,3′-[dithiobis(methylene)]bis[5-hydroxy-6-methyl-;4-Pyridinemethanol,3,3′-(dithiodimethylene)bis[5-hydroxy-6-methyl-;3,3′-[Dithiobis(methylene)]bis[5-hydroxy-6-methyl-4-pyridinemethanol];Bis-(4-hydroxymethyl-5-hydroxy-6-methyl-3-pyridylmethyl) disulfide;3,3′-(Dithiodimethylene)bis[5-hydroxy-6-methyl-4-pyridinemethanol];Pyritinol;Bis(2-methyl-3-hydroxy-4-hydroxymethylpyridyl-5-methyl) disulfide;Vitamin B6 disulfide;Bis[(3-hydroxy-4-hydroxymethyl-2-methyl-5-pyridyl)methyl] disulfide;Dipyridoxolyl disulfide;Pyridoxine-5-disulfide;Epocan;Bis[[5-hydroxy-4-(hydroxymethyl)-6-methyl-3-pyridyl]methyl] disulfide;Encefabol;Bonifen;Bonol;Pyrithioxin;Pyridoxine disulfide;Piritinol;Pyroxidine-5-disulfide
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Pyrithioxin is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia.

Pyritinol is a member of methylpyridines.|Pyritinol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders.|A neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity.

Pyritinol Basic Attributes

Molecular Weight：

368.47

Exact Mass：

368.47

EC Number：

214-150-1

UNII：

AK5Q5FZH2R

NSC Number：

759229

DSSTox ID：

DTXSID3048362

ATC Code：

N - Nervous system

HScode：

2933399090

Characteristics

PSA：

157

XLogP3：

1.2

Appearance：

Almost white crystalline powder.

Density：

1.448±0.06 g/cm3(Predicted)

Melting Point：

219 °C

Boiling Point：

742.8±60.0 °C(Predicted)

Flash Point：

>230 °F

Toxicity：

Oral-rat LD50: 6000 mg/kg; Oral-Mouse LD50: 5786 mg/kg

Flammability characteristics：

Thermal decomposition releases toxic nitrogen oxides, sulfur oxides, and hydrogen chloride gas

Collision Cross Section：

173.4 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

RTECS Number：

UT4836666

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H315-H318-H335

GHS Classification：

|Danger|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P332+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

practically nontoxic

Drug Information

MeSH Entry Terms：

Bonifen

Pyritinol Use and Manufacturing

cognition enhancer, nootropic

Computed Properties

Molecular Weight:368.5
XLogP3:1.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:368.08644947
Monoisotopic Mass:368.08644947
Topological Polar Surface Area:157
Heavy Atom Count:24
Complexity:346
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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