L-Penicillamine
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L-Penicillamine
structure -
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CAS No:
1113-41-3
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Formula:
C5H11NO2S
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Chemical Name:
L-Penicillamine
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Synonyms:
L-Valine,3-mercapto-;Valine,3-mercapto-,L-;3-Mercapto-L-valine;L-Penicillamine;(R)-Penicillamine;(+)-Penicillamine;NSC 241261;(R)-2-Amino-3-mercapto-3-methylbutanoic acid;(2R)-2-Amino-3-methyl-3-sulfanylbutanoic acid;16414-53-2;73706-37-3
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CAS No:
Description
white to almost white crystalline powderChEBI: The L-enantiomer of penicillamine.
L-penicillamine is the L-enantiomer of penicillamine. It is an enantiomer of a D-penicillamine.
Characteristics
102.12000
0.93
1.113 (estimate)
190-194 °C
251.8±35.0 °C(Predicted)
106.1±25.9 °C
63 ° (C=1, 1mol/L NaOH)
Store at RT.
0.00631mmHg at 25°C
LD50 i.p. in rats: 350 mg/kg (Jaffe)
Safety Information
NONH for all modes of transport
2
R36/37/38
26-36-22-24/25
YV9445500
Xi,Xn
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 47 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
L-Penicillamine Use and Manufacturing
As a Penicillin metabolite, L-Penicillamine can be used in the treatment of Wilson’s disease, Cystinuria, Scleroderma and arsenic poisoning. The mechanism of action of penicillamine is unknown, but some evidence suggests that it may involve the inhibition of angiogenesis, synovial fibroblast proliferation, or transcriptional activation. Because penicillamine can chelate copper and promote its excretion, it is used to treat Wilson’s disease (hepatolenticular degeneration) and has also bee
Computed Properties
Molecular Weight:149.21
XLogP3:-1.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:149.05104977
Monoisotopic Mass:149.05104977
Topological Polar Surface Area:64.3
Heavy Atom Count:9
Complexity:124
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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