2-Octanol

130.23

130.23

1719325

204-667-0

1170

14759

DTXSID0027014

Liquid|Colorless liquid

29051620

20.2

2.72

Clear colorless to slightly yellow Liquid

0.82 g/cm³

-38.6 °C

178.5 °C

160 °F

1.426

H2O: 0.1 g/100 mL (20 ºC)

Store below +30°C.

Vapour pressure, Pa at 25°C: 32

Relative vapour density (air = 1): 4.5

Oral-Rat LD50: 3200 mg/kg

Flammable; burning produces irritating fumes

0.80-7.40%(V)

Characteristically disagreeable, but aromatic

1.23e-04 atm-m3/mole|Henry's Law constant = 3.2276X10-5 atm-cu m/mol at 25 °C

Oily, refractive liquid; solubility: 0.096 mL/100 mL water; aromatic, yet somewhat unpleasant odor, particularly on heating; density 0.8193 at 20 °C/4 °C; bp: 178.5 °C at 760 mm Hg; index of refraction: 1.42025 at 20 °C/D /DL-form/|BP: 86 °C at 20 mm Hg; specific optical rotation: +9.9 deg at 17 °C/D; index of refraction: 0.8216 at 20 °C/4 °C /D-form/|Density: 0.8201 at 20 °C/4 °C; miscible with water; soluble in alcohol, ether, acetone; index of refraction: 1.4264 at 20 °C/D /L-Form/|Conversion factors: 1 ppm = 5.32 mg/cu m; 1 mg/L = 187.8 ppm|Hydroxyl radical reaction rate constant = 1.56X10-11 cu cm/molec-sec at 25 °C (est)

2-Octanol|B*: Compounds that form peroxides on concentration (distillation/evaporation)|2 samples, >1yrs, 2-20 ppm|Management of time-sensitive chemicals (JCHAS)

44.4 kJ/mol at 179.3 °C

Critical temperature: 629.5 K: critical pressure: 2.75 MPa

UN 1987

36/37/38-36/38-52/53

24/25-36-26

RH0795000

Xi

Warehouse ventilated, low temperature and dry

Chemical stability: Stable under recommended storage conditions.

P210, P264, P273, P280, P305+P351+P338, P337+P313, P370+P378, P403+P235, P501

H227

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Incompatible materials: Strong oxidizing agents

2-Octanol is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and b) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.

Combustible. Above 76 °C explosive vapour/air mixtures may be formed.

|Warning|H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P273, P280, P303+P361+P353, P370+P378, P391, P403+P235, and P501|Aggregated GHS information provided by 4 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H315 (14.53%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P310, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 1795 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H227: Combustible liquid [Warning Flammable liquids]|P210, P264, P273, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362, P370+P378, P403+P235, and P501|P210, P264, P280, P305+P351+P338, P337+P313, P370+P378, P403+P235, and P501|H226: Flammable liquid and vapor [Warning Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P301+P310, P303+P361+P353, P304+P340, P305+P351+P338, P312, P331, P332+P313, P337+P313, P370+P378, P403+P233, P403+P235, P405, and P501

Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).|Body Protection: impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.|Skin protection: Handle with gloves.|Eye/face protection: Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary. Use water spray to cool unopened containers.|Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Control of environmental exposure: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.|ACCIDENTAL RELEASE MEASURES. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided; Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations. Keep in suitable, closed containers for disposal.

Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.|Precautions for safe handling: Avoid contact with skin and eyes. Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.|Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in covered containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.

Separated from strong oxidants. Ventilation along the floor.

No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.

The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.

The substance defats the skin, which may cause dryness or cracking.

NO open flames. Above 76 °C use a closed system, ventilation and explosion-proof electrical equipment.

Use ventilation, local exhaust or breathing protection.

Protective gloves.

Wear safety goggles.

| 1 - Materials that, under emergency conditions, can cause significant irritation.| 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.| 0 - Materials that in themselves are normally stable, even under fire conditions.

The major hazards encountered in the use and handling of 2-octanol stem from its toxicologic properties. Toxic by all routes (ie, inhalation, ingestion, and dermal contact), exposure to this colorless, aromatic, oily liquid may occur from its production and use as a solvent for fats and waxes; in the manufacture of lacquers, enamels, plasticizers, wetting agents, antifoaming agents, hydraulic oils, petroleum additives, and perfumes; and in the masking of industrial odors. Effects from exposure may include headache, nausea, dizziness, eye irritation, drying of the skin, pulmonary tract irritation, and CNS depression. In activities and situations where over-exposure may occur, wear a self-contained breathing apparatus. If contact should occur, irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes and wash exposed skin thoroughly with soap and water. 2-Octanol must be moderately heated before ignition will occur. Normal firefighting procedures may be used to fight 2-octanol fires, including the use of water spray to cool the substance to below its flashpoint.

2-Octanol was qualitatively identified as a component of leachate from a municipal waste landfill in Norman, OK(1). The effluent of a Los Angeles Co municipal sewage treatment facility contained 2-octanol at 10 ug/L(2).

moderately toxic

IDENTIFICATION AND USE: 2-Octanol is a colorless liquid used in the manufacture of perfumes, disinfectant soaps and to prevent foaming. It is also used as a solvent for fats and waxes. HUMAN EXPOSURE AND TOXICITY: No human toxicity studies have been found to date. ANIMAL STUDIES: 2-Octanol is slightly irritating to guinea pig skin. Rats were exposed by inhalation to 34 to 56 ppm 2-octanol, 2hr/day, 6 days/week for 4.5 months. Mild reversible central nervous system effects (not described) were reported, as well as hematologic changes (decreased hemoglobin and erythrocyte numbers) and minor changes in heart, liver and kidney. 2-Octanol (2 mL/day) applied for 6 days to the shaven skin of rabbits caused erythema, inflammation, and cracking of the skin, which healed in 10 to 12 days. The application of 2-octanol to the eyes of rabbits caused pronounced erythema.

LD50 Guinea pig dermal >0.5 g/animal|LD50 Mouse oral 4.0 g/kg|LD50 Rat oral > 3.2 g/kg

2-Octanol was identified in fresh ginger root(1), oil of Reunion geranium, a few species of mint and lavender, apple, banana, kumquat peel oil, cranberry, asparagus, peas, thyme, hop oil, tea, oats, soybeans, coconut meat, Brazil nut, buckwheat, loquat, sweet corn(2) and the leaf of tomato plants(3).

2-Octanol's production and use as a solvent, in the manufacture of plasticizers, wetting and foam control agents, hydraulic oils, petroleum additives, perfume intermediates and in masking of industrial odors(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 32(SRC), determined from a structure estimation method(2), indicates that 2-octanol is expected to have very high mobility in soil(SRC). Volatilization of 2-octanol from moist soil surfaces is expected given a Henry's Law constant of 3.23X10-5 atm-cu m/mole(3). 2-Octanol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.242 mm Hg at 25 °C(4). A 76% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is an important environmental fate process in soil(SRC).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 32(SRC), determined from a structure estimation method(2), indicates that 2-octanol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 3.23X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 34 hours and 14 days, respectively(SRC). 2-Octanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(5), an estimated BCF of 38(SRC), from its log Kow of 2.90(6) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). First order rate constants for the biodegradation of 2-octanol using an activated sludge inoculum were measured as 1120 1/hour(7) and 388 1/hour(8), indicating that biodegradation may be an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-octanol, which has a vapor pressure of 0.242 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-octanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 32 hours(SRC), calculated from its rate constant of 1.21X10-11 cu cm/molecule-sec at 25 °C(3). 2-Octanol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

The rate constant for the vapor-phase reaction of 2-octanol with photochemically-produced hydroxyl radicals has been reported as 1.21X10-11 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 32 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 2-Octanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(2). 2-Octanol does not contain chromophores that absorb at wavelengths >290 nm(3) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC).

An estimated BCF of 38 was calculated in fish for 2-octanol(SRC), using a log Kow of 2.90(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of 2-octanol can be estimated to be 32(SRC). According to a classification scheme(2), this estimated Koc value suggests that 2-octanol is expected to have very high mobility in soil.

The Henry's Law constant for 2-octanol is reported as 3.23X10-5 atm-cu m/mole(1). This Henry's Law constant indicates that 2-octanol is expected to volatilize from water surfaces(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as 34 hours(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as 14 days(SRC). 2-Octanol's Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). 2-Octanol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 0.242 mm Hg(3).

GROUNDWATER: 2-Octanol was qualitatively identified as a component of groundwater below a municipal waste landfill in Norman, OK(1).

2-Octanol was identified as a volatile component of mountain(1) and blue(2) cheeses, and fresh ginger root(3). 2-Octanol was identified in oil of Reunion geranium, a few species of mint and lavender; it is reported in apple, banana, kumquat peel oil, cranberry, asparagus, peas, thyme, cheeses, chicken and beef fat, hop oil, beer, cognac, rum, grape wines, tea, oats, soybeans, coconut meat, Brazil nut, buckwheat, loquat, sweet corn and bilberry wine(4). 2-Octanol has been detected in beer, wine and spirits(5).

According to the 2012 TSCA Inventory Update Reporting data, 5 reporting facilities estimate the number of persons reasonably likely to be exposed in the manufacturing, processing, or use of 2-octanol in the United States may be as low as <10 workers up to the range of 100-499 workers per plant; the data may be greatly underestimated due to confidential business information (CBI) or unknown values(1).|NIOSH (NOES Survey 1981-1983) has statistically estimated that 3640 workers (1361 of these are female) were potentially exposed to 2-octanol in the US(1). Occupational exposure to 2-octanol may occur through inhalation and dermal contact with this compound at workplaces where 2-octanol is produced or used. Monitoring data indicate that the general population may be exposed to 2-octanol via inhalation of ambient air, ingestion of food and beverages, and dermal contact with consumer products containing 2-octanol(SRC).

2-Octanol was detected in the air expired from humans(1-4); 32.3% of the 387 samples collected from 54 subjects had an average 2-octanol concentration of 0.89 ng/L(2).

THE CONTENT OF METHYL HEXYL KETONE RANGES FROM 2% MAX IN THE CHEM GRADE TO 14% MAX IN THE SOLVENT GRADE.

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Higher alcohols (>3 carbons) and related compounds/|/SRP:/ Basic Treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Higher alcohols (>3 carbons) and related compounds/|/SRP:/ Advanced Treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques, with a bag-valve-mask device, may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Monitor for signs of hypoglycemia (decreased LOC, tachycardia, pallor, dilated pupils, diaphoresis, and/or dextrose strip or glucometer readings below 50 mg) and administer 50% dextrose if necessary ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Higher alcohols (>3 carbons) and related compounds/|Emergency and supportive measures. 1. General. Provide basic supportive care for all symptomatic patients. Maintain an open airway and assist ventilation if necessary. Administer supplemental oxygen. Monitor arterial blood gases or oximetry, chest radiographs, and ECG and admit symptomatic patients to an intensive care setting. Use epinephrine and other beta-adrenergic medications with caution in patients with significant hydrocarbon intoxication because arrhythmias may be induced. 2. Pulmonary aspiration. Patients who remain completely asymptomatic after 4-6 hours of observation may be discharged. In contrast, if the patient is coughing on arrival, aspiration probably has occurred. Administer supplemental oxygen and treat bronchospasm and hypoxia if they occur. Do not use steroids or prophylactic antibiotics. 3. Ingestion. In the vast majority of accidental childhood ingestions, less than 5-10 mL is actually swallowed and systemic toxicity is rare. Treatment is primarily supportive. Injection. For injections into the fingertip or hand, especially those involving a high-pressure paint gun, consult with a plastic or hand surgeon immediately, as prompt wide exposure, irrigation, and debridement are often required. /Hydrocarbons/|For more Antidote and Emergency Treatment (Complete) data for 2-OCTANOL (7 total), please visit the HSDB record page.

2-octanol

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Cough. Sore throat.

Dry skin.

Redness. Pain.

Grades: Technical 92-99%; pure.

Pesticide, fertilizer, and other agricultural chemical manufacturing|2-Octanol: ACTIVE

Food additives -> Flavoring Agents|Fatty Acyls [FA] -> Fatty alcohols [FA05]|Environmental transformation -> Pesticide transformation products (metabolite, successor)

Octan-2-ol is a known environmental transformation product of Fluroxypyr.

Flavoring Agents