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Home > Encyclopedia > Crizotinib

Crizotinib

Crizotinib structure
  • CAS No:

    877399-52-5

  • Formula:

    C21H22Cl2FN5O

  • Synonyms:

    (5-(pyridin-3-yl)-1,3,4-oxadiazol-2-yl)methanamine;3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine;3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-Pyridinamine;Crizotinib;PF2341066;2-pyridinamine, 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1h-pyrazol-4-yl]-;

  • China Export:

    From 2018.11 to 2019.11, total export volume of Crizotinib from China was 99,860,829KG while total export value was $1,973,802,887. The biggest proportion of exporting volume in the last 12 months was 10.61% in 2019.05.

  • Categories:

    API  >  Inhibitor Drugs

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Description

Crizotinib is a potent inhibitor of c-Met and ALK with an IC50 of 11 nM and 24 nM in cell-based assays, respectively.

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Basic Attributes

  • 877399-52-5

  • C21H22Cl2FN5O

  • 450.343

  • 449.118530

  • 78

  • 3.7

  • 1308068-626-2

  • KTEIFNKAUNYNJU-GFCCVEGCSA-N

  • 6

  • 2

  • 0.33

  • 5

Characteristics

  • 1.5±0.1 g/cm3

  • 192 °C

  • 599.177°C at 760 mmHg

  • 316.2±30.1 °C

  • 1.673

Safety Information

  • IRRITANT

  • 29333990

  • 3077

  • 3

  • 9

  • 24/25

  • P273-P280-P305 + P351 + P338

  • H317-H319-H341-H400

Usage

PF-2341066 (Crizotinib) is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM, respectivley Crizotinib is a small molecule tyrosine kinase inhibitor (TKI) that targets anaplastic lymphoma kinase (ALK), ROS1, and another oncogene receptor tyrosine kinase MET.

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China Crizotinib Export Data

Data referenced from General Administration of Customs,P.R.China

2018.11-2019.11 China - America  Crizotinib Export Data

From 2018.11 to 2019.11, total export volume of Crizotinib from China to America was 11,987,610KG while total export value was $407,366,436. The biggest proportion of exporting volume in the last 12 months was 15.59% in 2019.01.

2018.11-2019.11 China Crizotinib Export Data

From 2018.11 to 2019.11, total export volume of Crizotinib from China was 99,860,829KG while total export value was $1,973,802,887. The biggest proportion of exporting volume in the last 12 months was 10.61% in 2019.05.

2018.11-2019.11 TOP10 Purchasing Countries' Export Data of Chinese Crizotinib

From 2018.11 to 2019.11, China has exported Crizotinib to 111 countries in total. Country ranks by import volume from high to low is India, America, Brazil, Vietnam, Israel, Japan, Argentina, Germany, Taiwan, Pakistan. The highest export volume was China to India, accounting for 11.17% of the total volume of China.

Check Export Data for More Purchasing Countries

Purchasing Country Export Volume(KG) Export Percentage Export Value($)

India

21,350,559

11.17%

316,020,454

America

11,987,610

6.27%

407,366,436

Brazil

11,098,233

5.81%

170,622,389

Vietnam

4,428,640

2.32%

45,462,605

Israel

3,648,663

1.91%

74,956,063

Japan

3,475,754

1.82%

110,969,106

Argentina

2,736,884

1.43%

57,288,649

Germany

2,686,541

1.41%

45,609,062

Taiwan

2,499,110

1.31%

19,750,602

Pakistan

2,471,193

1.29%

47,513,297

Australia

2,425,936

1.27%

40,579,730

Indonesia

2,391,780

1.25%

17,033,587

Colombia

2,212,161

1.16%

33,453,885

Russia

2,205,241

1.15%

54,499,374

Thailand

2,068,269

1.08%

16,336,312

Korea

1,878,781

0.98%

47,903,598

Mexico

1,669,748

0.87%

22,791,156

Belgium

1,637,500

0.86%

53,140,008

South Africa

1,629,904

0.85%

20,453,726

Iran

1,557,276

0.81%

25,370,665

Malaysia

1,283,148

0.67%

10,120,076

Egypt

1,000,415

0.52%

8,936,461

Singapore

959,891

0.50%

62,954,445

United Kingdom

906,803

0.47%

30,428,722

Turkey

728,551

0.38%

17,439,103

Portugal

716,235

0.37%

8,744,130

France

627,157

0.33%

20,669,308

Netherlands

613,471

0.32%

15,891,853

Peru

440,254

0.23%

3,918,368

Poland

403,366

0.21%

11,584,658

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