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Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride (1:1)

Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride (1:1) structure

CAS No:
28783-41-7
Formula:
C7H9NS.ClH
Chemical Name:
Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride (1:1)
Synonyms:
Thieno[3,2-c]pyridine,4,5,6,7-tetrahydro-,hydrochloride (1:1);Thieno[3,2-c]pyridine,4,5,6,7-tetrahydro-,hydrochloride;4,5,6,7-Tetrahydrothieno[3,2-c]pyridine hydrochloride
Categories:
Pharmaceutical Intermediates > Cardiovascular Agents

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Description

Off-White Solid

Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride (1:1) Basic Attributes

Molecular Weight：

139.22

Exact Mass：

175.022247

EC Number：

249-220-0

HScode：

2934999090

Characteristics

PSA：

40.3

XLogP3：

2.52460

Appearance：

Off-White Solid

Density：

1.143g/cm3

Melting Point：

220-230 °C

Boiling Point：

242.9ºC at 760 mmHg

Flash Point：

100.7ºC

Vapor Pressure：

0.0331mmHg at 25°C

Safety Information

Hazard category：

IRRITANT

hazard class code：

36/37/38

safety instructions：

26-36/37/39-37

Precautionary statement(s)：

P264, P270, P280, P301+P312, P302+P352, P305+P351+P338, P321, P330, P332+P313, P337+P313, P362, P501

Hazard Statements：

H302

Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride (1:1) Use and Manufacturing

Methods of Manufacturing

Preparation of 4, 5, 6, 7-Tetrahydro theino-[3, 2-c]-pyridine hydrochlorideIn a 2 ltr 4-necked flask equipped with a thermometer and mechanical stirrer, 2-thienyl ethylamine (lOOg, 0.79 moles) was added in dichloromethane (600 ml) at 25 °C (+/-5 °C) and stir for 5 to 10 minutes. Add paraformaldehyde (26.4 g, 0.88 moles) to the reaction mass and reflux azeotropiccally for 4 to 6 hrs at 40 to 45 °C. Cool the reaction to room temperature and add 7percent hydrochloric acid in Ν, Ν-dimethyl formamide (200 ml) to the reaction mass at 25 °C (+/-5 °C). Stir the reaction mass for 4 to 6 hrs at 70 °C (+/-5 °C). Cool the reaction to 15 °C (+/-2 °C) and stir for 8 to 10 hrs for crystallisation. Filter the product and wash with chilled dichloromethane. Dry the material under vacuum at 30 to 40 °C to obtain 4, 5, 6, 7-Tetrahydro theino-[3, 2-c]-pyridine hydrochloride (120 g, 99percent).

Uses

An intemediate of Clopidogrel andPrasugrel.

Material

Tetrahydrofuran

Ammonium chloride

Ethyl acetate

Formaldehyde

Isopropanol

Hydrochloric acid

Sulfuric acid

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Guide of Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride (1:1)

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Material
Recommended Suppliers
Latest News
Learn More Other Chemicals

Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride (1:1)

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